Institution
La Trobe University
Education•Melbourne, Victoria, Australia•
About: La Trobe University is a education organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Population & Health care. The organization has 13370 authors who have published 41291 publications receiving 1138269 citations. The organization is also known as: LaTrobe University & LTU.
Papers published on a yearly basis
Papers
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TL;DR: The different pathways involved in sorting proteins into mitochondrial subcompartments are reviewed and how these structures correlate with previously ascribed functions are discussed.
195 citations
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TL;DR: Exposure to pornography is routine among children and young people, with a range of notable and often troubling effects as discussed by the authors, particularly among younger children, exposure to pornography may be disturbing or upsetting, and, especially among boys and young men who are frequent consumers of pornography, including of more violent materials, consumption intensifies attitudes supportive of sexual coercion and increases their likelihood of perpetrating assault.
Abstract: Exposure to pornography is routine among children and young people, with a range of notable and often troubling effects. Particularly among younger children, exposure to pornography may be disturbing or upsetting. Exposure to pornography helps to sustain young people's adherence to sexist and unhealthy notions of sex and relationships. And, especially among boys and young men who are frequent consumers of pornography, including of more violent materials, consumption intensifies attitudes supportive of sexual coercion and increases their likelihood of perpetrating assault. While children and young people are sexual beings and deserve age-appropriate materials on sex and sexuality, pornography is a poor, and indeed dangerous, sex educator.
194 citations
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TL;DR: To develop effective selection programmes for new traits, the development of large databases is necessary so that high-reliability breeding values can be estimated, and for expensive-to-record traits, extensive phenotyping in combination with genotyping of females is a possibility.
Abstract: For several decades, breeding goals in dairy cattle focussed on increased milk production. However, many functional traits have negative genetic correlations with milk yield, and reductions in genetic merit for health and fitness have been observed. Herd management has been challenged to compensate for these effects and to balance fertility, udder health and metabolic diseases against increased production to maximize profit without compromising welfare. Functional traits, such as direct information on cow health, have also become more important because of growing concern about animal well-being and consumer demands for healthy and natural products. There are major concerns about the impact of drugs used in veterinary medicine on the spread of antibiotic-resistant strains of bacteria that can negatively impact human health. Sustainability and efficiency are also increasingly important because of the growing competition for high-quality, plant-based sources of energy and protein. Disruptions to global environments because of climate change may encourage yet more emphasis on these traits. To be successful, it is vital that there be a balance between the effort required for data recording and subsequent benefits. The motivation of farmers and other stakeholders involved in documentation and recording is essential to ensure good data quality. To keep labour costs reasonable, existing data sources should be used as much as possible. Examples include the use of milk composition data to provide additional information about the metabolic status or energy balance of the animals. Recent advances in the use of mid-infrared spectroscopy to measure milk have shown considerable promise, and may provide cost-effective alternative phenotypes for difficult or expensive-to-measure traits, such as feed efficiency. There are other valuable data sources in countries that have compulsory documentation of veterinary treatments and drug use. Additional sources of data outside of the farm include, for example, slaughter houses (meat composition and quality) and veterinary labs (specific pathogens, viral loads). At the farm level, many data are available from automated and semi-automated milking and management systems. Electronic devices measuring physiological status or activity parameters can be used to predict events such as oestrus, and also behavioural traits. Challenges concerning the predictive biology of indicator traits or standardization need to be solved. To develop effective selection programmes for new traits, the development of large databases is necessary so that high-reliability breeding values can be estimated. For expensive-to-record traits, extensive phenotyping in combination with genotyping of females is a possibility.
194 citations
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Royal Children's Hospital1, University of Melbourne2, University of Glasgow3, Utrecht University4, Istituto Giannina Gaslini5, McGill University6, University of Oxford7, University of Western Australia8, Princess Margaret Hospital for Children9, La Trobe University10, Harvard University11, Monash University12, Boston Children's Hospital13, University of Genoa14, University of Groningen15, Université de Montréal16, University of Colorado Denver17, University of Iowa18, Children's Medical Center of Dallas19, University of Texas at Dallas20, Northwestern University21, Vanderbilt University22, Dartmouth College23, University of Pennsylvania24, University of Vermont25, Alfred Hospital26
TL;DR: RA in infants undergoing inguinal herniorrhaphy reduces apnea in the early postoperative period, and cardiorespiratory monitoring should be used for all ex-premature infants.
Abstract: Background: Postoperative apnea is a complication in young infants. Awake regional anesthesia (RA) may reduce the risk; however, the evidence is weak. The General Anesthesia compared to Spinal anesthesia study is a randomized, controlled trial designed to assess the influence of general anesthesia (GA) on neurodevelopment. A secondary aim is to compare rates of apnea after anesthesia. Methods: Infants aged 60 weeks or younger, postmenstrual age scheduled for inguinal herniorrhaphy, were randomized to RA or GA. Exclusion criteria included risk factors for adverse neurodevelopmental outcome and infants born less than 26 weeks gestation. The primary outcome of this analysis was any observed apnea up to 12 h postoperatively. Apnea assessment was unblinded. Results: Three hundred sixty-three patients were assigned to RA and 359 to GA. Overall, the incidence of apnea (0 to 12 h) was similar between arms (3% in RA and 4% in GA arms; odds ratio [OR], 0.63; 95% CI, 0.31 to 1.30, P = 0.2133); however, the incidence of early apnea (0 to 30 min) was lower in the RA arm (1 vs. 3%; OR, 0.20; 95% CI, 0.05 to 0.91; P = 0.0367). The incidence of late apnea (30 min to 12 h) was 2% in both RA and GA arms (OR, 1.17; 95% CI, 0.41 to 3.33; P = 0.7688). The strongest predictor of apnea was prematurity (OR, 21.87; 95% CI, 4.38 to 109.24), and 96% of infants with apnea were premature. Conclusions: RA in infants undergoing inguinal herniorrhaphy reduces apnea in the early postoperative period. Cardiorespiratory monitoring should be used for all ex-premature infants.
194 citations
01 Jan 2008
TL;DR: This paper reports on part of a three-year project to identify practical and theoretical issues entailed in developing a pedagogical framework to guide teacher understanding and practices to maximize representational opportunities for learners to develop conceptual understandings in science.
Abstract: There is growing research interest in both the challenges and opportunities learners face in trying to represent scientific understanding, processes and reasoning. These challenges are increasingly well understood by researchers, including integrating verbal, visual and mathematical modes in science discourse, and making strong conceptual links between classroom experiences and diverse 3D and 2D representations. However, a matching enhanced pedagogy of representation-rich learning opportunities, including their theoretical justification, is much less clearly established. Our paper reports on part of a three-year project to identify practical and theoretical issues entailed in developing a pedagogical framework to guide teacher understanding and practices to maximize representational opportunities for learners to develop conceptual understandings in science.
194 citations
Authors
Showing all 13601 results
Name | H-index | Papers | Citations |
---|---|---|---|
Rasmus Nielsen | 135 | 556 | 84898 |
C. N. R. Rao | 133 | 1646 | 86718 |
James Whelan | 128 | 786 | 89180 |
Jacqueline Batley | 119 | 1212 | 68752 |
Eske Willerslev | 115 | 367 | 43039 |
Jonathan E. Shaw | 114 | 629 | 108114 |
Ary A. Hoffmann | 113 | 907 | 55354 |
Mike Clarke | 113 | 1037 | 164328 |
Richard J. Simpson | 113 | 850 | 59378 |
Alan F. Cowman | 111 | 379 | 38240 |
David C. Page | 110 | 509 | 44119 |
Richard Gray | 109 | 808 | 78580 |
David S. Wishart | 108 | 523 | 76652 |
Alan G. Marshall | 107 | 1060 | 46904 |
David A. Williams | 106 | 633 | 42058 |