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Institution

La Trobe University

EducationMelbourne, Victoria, Australia
About: La Trobe University is a education organization based out in Melbourne, Victoria, Australia. It is known for research contribution in the topics: Population & Health care. The organization has 13370 authors who have published 41291 publications receiving 1138269 citations. The organization is also known as: LaTrobe University & LTU.


Papers
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Journal ArticleDOI
TL;DR: The different pathways involved in sorting proteins into mitochondrial subcompartments are reviewed and how these structures correlate with previously ascribed functions are discussed.

195 citations

Journal ArticleDOI
TL;DR: Exposure to pornography is routine among children and young people, with a range of notable and often troubling effects as discussed by the authors, particularly among younger children, exposure to pornography may be disturbing or upsetting, and, especially among boys and young men who are frequent consumers of pornography, including of more violent materials, consumption intensifies attitudes supportive of sexual coercion and increases their likelihood of perpetrating assault.
Abstract: Exposure to pornography is routine among children and young people, with a range of notable and often troubling effects. Particularly among younger children, exposure to pornography may be disturbing or upsetting. Exposure to pornography helps to sustain young people's adherence to sexist and unhealthy notions of sex and relationships. And, especially among boys and young men who are frequent consumers of pornography, including of more violent materials, consumption intensifies attitudes supportive of sexual coercion and increases their likelihood of perpetrating assault. While children and young people are sexual beings and deserve age-appropriate materials on sex and sexuality, pornography is a poor, and indeed dangerous, sex educator.

194 citations

Journal ArticleDOI
01 Feb 2015-Animal
TL;DR: To develop effective selection programmes for new traits, the development of large databases is necessary so that high-reliability breeding values can be estimated, and for expensive-to-record traits, extensive phenotyping in combination with genotyping of females is a possibility.
Abstract: For several decades, breeding goals in dairy cattle focussed on increased milk production. However, many functional traits have negative genetic correlations with milk yield, and reductions in genetic merit for health and fitness have been observed. Herd management has been challenged to compensate for these effects and to balance fertility, udder health and metabolic diseases against increased production to maximize profit without compromising welfare. Functional traits, such as direct information on cow health, have also become more important because of growing concern about animal well-being and consumer demands for healthy and natural products. There are major concerns about the impact of drugs used in veterinary medicine on the spread of antibiotic-resistant strains of bacteria that can negatively impact human health. Sustainability and efficiency are also increasingly important because of the growing competition for high-quality, plant-based sources of energy and protein. Disruptions to global environments because of climate change may encourage yet more emphasis on these traits. To be successful, it is vital that there be a balance between the effort required for data recording and subsequent benefits. The motivation of farmers and other stakeholders involved in documentation and recording is essential to ensure good data quality. To keep labour costs reasonable, existing data sources should be used as much as possible. Examples include the use of milk composition data to provide additional information about the metabolic status or energy balance of the animals. Recent advances in the use of mid-infrared spectroscopy to measure milk have shown considerable promise, and may provide cost-effective alternative phenotypes for difficult or expensive-to-measure traits, such as feed efficiency. There are other valuable data sources in countries that have compulsory documentation of veterinary treatments and drug use. Additional sources of data outside of the farm include, for example, slaughter houses (meat composition and quality) and veterinary labs (specific pathogens, viral loads). At the farm level, many data are available from automated and semi-automated milking and management systems. Electronic devices measuring physiological status or activity parameters can be used to predict events such as oestrus, and also behavioural traits. Challenges concerning the predictive biology of indicator traits or standardization need to be solved. To develop effective selection programmes for new traits, the development of large databases is necessary so that high-reliability breeding values can be estimated. For expensive-to-record traits, extensive phenotyping in combination with genotyping of females is a possibility.

194 citations

Journal ArticleDOI
Andrew Davidson1, Andrew Davidson2, Neil S. Morton3, Sarah J Arnup, Jurgen C. de Graaff4, Nicola Disma5, Davinia E. Withington6, Geoff Frawley1, Geoff Frawley2, Rodney W. Hunt1, Rodney W. Hunt2, Pollyanna Hardy7, Magda Khotcholava, Britta S von Ungern Sternberg8, Britta S von Ungern Sternberg9, Niall C. T. Wilton, Pietro Tuo5, Ida Salvo, Gillian D Ormond, Robyn Stargatt10, Bruno Guido Locatelli, Mary Ellen McCann11, Katherine J Lee10, Suzette Sheppard, Penelope L Hartmann, Philip Ragg1, Marie Backstrom12, David Costi13, Britta S. von Ungern-Sternberg9, Britta S. von Ungern-Sternberg8, Graham Knottenbelt, Giovanni Montobbio5, Leila Mameli5, Gaia Giribaldi5, Alessio Pini Prato5, Girolamo Mattioli14, Andrea Wolfler, Francesca Izzo, Valter Sonzogni, Jose T D G Van Gool4, Sandra Numan4, Cor J. Kalkman4, J. H M Hagenaars15, Anthony Absalom15, Frouckje M. Hoekstra15, Martin J. Volkers15, Koto Furue16, Josee Gaudreault16, Charles B. Berde11, Sulpicio G. Soriano11, Vanessa Young11, Navil F. Sethna11, Pete G. Kovatsis11, Joseph P. Cravero11, David C. Bellinger11, Jacki Marmor11, Anne M. Lynn13, Iskra Ivanova13, Agnes Hunyady13, Shilpa Verma13, David M. Polaner17, David M. Polaner13, Joss J. Thomas18, Martin Meuller18, Denisa Haret18, Peter Szmuk19, Jeffery Steiner19, Brian Kravitz20, Brian Kravitz19, Santhanam Suresh21, Stephen R. Hays22, Andreas H. Taenzer23, Lynne G. Maxwell24, Robert K. Williams25, Graham Bell, Liam Dorris, Claire Adey, Oliver Bagshaw, Anthony Chisakuta, Ayman I. Eissa, Peter A. Stoddart, Annette J.M. Davis, Paul S. Myles, Andy Wolf, Neil McIntosh, John B. Carlin, Kate Leslie26, Jonathan De Lima, Greg Hammer, David Field, Val Gebski, Dick Tibboel 
TL;DR: RA in infants undergoing inguinal herniorrhaphy reduces apnea in the early postoperative period, and cardiorespiratory monitoring should be used for all ex-premature infants.
Abstract: Background: Postoperative apnea is a complication in young infants. Awake regional anesthesia (RA) may reduce the risk; however, the evidence is weak. The General Anesthesia compared to Spinal anesthesia study is a randomized, controlled trial designed to assess the influence of general anesthesia (GA) on neurodevelopment. A secondary aim is to compare rates of apnea after anesthesia. Methods: Infants aged 60 weeks or younger, postmenstrual age scheduled for inguinal herniorrhaphy, were randomized to RA or GA. Exclusion criteria included risk factors for adverse neurodevelopmental outcome and infants born less than 26 weeks gestation. The primary outcome of this analysis was any observed apnea up to 12 h postoperatively. Apnea assessment was unblinded. Results: Three hundred sixty-three patients were assigned to RA and 359 to GA. Overall, the incidence of apnea (0 to 12 h) was similar between arms (3% in RA and 4% in GA arms; odds ratio [OR], 0.63; 95% CI, 0.31 to 1.30, P = 0.2133); however, the incidence of early apnea (0 to 30 min) was lower in the RA arm (1 vs. 3%; OR, 0.20; 95% CI, 0.05 to 0.91; P = 0.0367). The incidence of late apnea (30 min to 12 h) was 2% in both RA and GA arms (OR, 1.17; 95% CI, 0.41 to 3.33; P = 0.7688). The strongest predictor of apnea was prematurity (OR, 21.87; 95% CI, 4.38 to 109.24), and 96% of infants with apnea were premature. Conclusions: RA in infants undergoing inguinal herniorrhaphy reduces apnea in the early postoperative period. Cardiorespiratory monitoring should be used for all ex-premature infants.

194 citations

01 Jan 2008
TL;DR: This paper reports on part of a three-year project to identify practical and theoretical issues entailed in developing a pedagogical framework to guide teacher understanding and practices to maximize representational opportunities for learners to develop conceptual understandings in science.
Abstract: There is growing research interest in both the challenges and opportunities learners face in trying to represent scientific understanding, processes and reasoning. These challenges are increasingly well understood by researchers, including integrating verbal, visual and mathematical modes in science discourse, and making strong conceptual links between classroom experiences and diverse 3D and 2D representations. However, a matching enhanced pedagogy of representation-rich learning opportunities, including their theoretical justification, is much less clearly established. Our paper reports on part of a three-year project to identify practical and theoretical issues entailed in developing a pedagogical framework to guide teacher understanding and practices to maximize representational opportunities for learners to develop conceptual understandings in science.

194 citations


Authors

Showing all 13601 results

NameH-indexPapersCitations
Rasmus Nielsen13555684898
C. N. R. Rao133164686718
James Whelan12878689180
Jacqueline Batley119121268752
Eske Willerslev11536743039
Jonathan E. Shaw114629108114
Ary A. Hoffmann11390755354
Mike Clarke1131037164328
Richard J. Simpson11385059378
Alan F. Cowman11137938240
David C. Page11050944119
Richard Gray10980878580
David S. Wishart10852376652
Alan G. Marshall107106046904
David A. Williams10663342058
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023102
2022398
20213,407
20202,992
20192,661
20182,394