Long Island University

About: Long Island University is a education organization based out in Brookville, New York, United States. It is known for research contribution in the topics: Population & Context (language use). The organization has 2647 authors who have published 4924 publications receiving 108757 citations.

Oxidative stress is the master operator of drug and chemically-induced programmed and unprogrammed cell death: Implications of natural antioxidants in vivo

Abstract: ROS, RNS, BRIs and ROS-RNS hybrids are produced during drug or chemical metabolism in vivo. These reactive species are instrumental to the culmination of cellular oxidative stress (OS). OS, once turned on, does not spare any vital intracellular macromolecule, such as glutathione, DNA, RNA, proteins, enzymes, lipids and ATP. Since concentration gradients of such components are very delicately balanced for normal cellular functioning, a gross perturbation leads to cell injury and cell death. Abundant evidence now suggests that intracellular antioxidants keep OS in check and maintain homeostasis. Our laboratory has focused on the role of OS in orchestrating various forms of cell death during drug and chemically-induced target organ toxicity and their counteraction by various natural or synthetic antioxidants in in vivo models. Despite complexity of the in vivo models, results show that metabolism of xenobiotics are invariably associated with different degrees of OS and natural antioxidants such as grape seed extract, bitter melon extract (Momordica charantia) and N-acetylcysteine (NAC) which were very effective in counteracting organ toxicities by minimizing events linked to OS (lipid peroxidation and total glutathione), and CAD-mediated DNA fragmentation. Phytoextract exposure rescued cells from toxic assaults, protected genomic integrity, and minimized apoptotic, necrotic and apocrotic (oncotic necrosis) cell deaths. Pre-exposure mode was more effective than post-exposure route. Overall scenario suggests that OS may have been the prime modulator of death and/or survival programs, whereas, antioxidants may have imparted a dual role in either erasing death signals or reviving survival signals, and a combination of antioxidants may be more beneficial than a single entity to influence a number of intracellular events operating simultaneously to neutralize chaotic toxicological consequences.

Constructing a Roadmap for Future Universal Screening Research Beyond Academics

Abstract: The majority of the literature on universal screening in education is devoted to academic screeners. However, research clearly indicates that other aspects of student functioning are closely associated with outcomes inside and outside of school. As a result, there are gaps in the current literature that call for additional research extending beyond academics to explore the development and use of other screening tools to better detect students who are at risk for difficulties. Consistent with the purpose of this special series, the aim of this article is to establish a roadmap for future research on universal screening efforts beyond academic domains. The following six themes were integrated into a roadmap that will serve as a guide for future research directed at improving the accuracy, feasibility, effectiveness, and breadth of screening practices in education: (a) universal screening research across multiple domains; (b) determination of the optimal informant; (c) linking screening results to problem-so...

Leaving Home: Homesickness, Place Attachment, and Transition Among Residential College Students.

Abstract: A phenomenological analysis of interviews with first year college students found that participants whose parents lived farthest away reported greater homesickness and made more visits home than did those whose parents lived closer. Homesick students showed lower scores on measures of self-esteem, ego identity and internal locus of control, and indicated an emphasis on denial, a longing for family and friends, and missing one's house and hometown. Adjustment included an appreciation for newly made friends at college, making the dormitory room feel more homelike, maintaining email and telephone contact with parents and old friends, and generally viewing the experience as process.