Long Island University

About: Long Island University is a education organization based out in Brookville, New York, United States. It is known for research contribution in the topics: Population & Context (language use). The organization has 2647 authors who have published 4924 publications receiving 108757 citations.

Reframing the Conversation About Students With Limited or Interrupted Formal Education: From Achievement Gap to Cultural Dissonance

Abstract: U.S. schools face increasing pressure to ensure that all students succeed, yet the dropout rate for English learners is alarmingly high, especially for those with limited or interrupted formal schooling (SLIFE). Serving SLIFE can be challenging because they not only need to master language and content but also need to develop literacy skills and learn to operate in formal classroom settings. We describe a culturally responsive instructional model that prepares SLIFE to access curriculum and instruction, and succeed on standardized testing.

Sibling influence, gender roles, and the sexual socialization of urban early adolescent girls.

Abstract: This study examined whether older siblings influence early adolescent girls' sexual socialization. Participants were 180 girls, 12 to 14 years old, from predominantly ethnic minority backgrounds. T...

Targeting MTA1/HIF-1α signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression.

Abstract: The metastasis-associated protein 1(MTA1)/histone deacetylase (HDAC) unit is a cancer progression-related epigenetic regulator, which is overexpressed in hormone-refractory and metastatic prostate cancer (PCa). In our previous studies, we found a significantly increased MTA1 expression in a prostate-specific Pten-null mouse model. We also demonstrated that stilbenes, namely resveratrol and pterostilbene (Pter), affect MTA1/HDAC signaling, including deacetylation of tumor suppressors p53 and PTEN. In this study, we examined whether inhibition of MTA1/HDAC using combination of Pter and a clinically approved HDAC inhibitor, SAHA (suberoylanilide hydroxamic acid, vorinostat), which also downregulates MTA1, could block prostate tumor progression in vivo. We generated and utilized a luciferase reporter in a prostate-specific Pten-null mouse model (Pb-Cre+ ; Ptenf/f ; Rosa26Luc/+ ) to evaluate the anticancer efficacy of Pter/SAHA combinatorial approach. Our data showed that Pter sensitized tumor cells to SAHA treatment resulting in inhibiting tumor growth and additional decline of tumor progression. These effects were dependent on the reduction of MTA1-associated proangiogenic factors HIF-1α, VEGF, and IL-1β leading to decreased angiogenesis. In addition, treatment of PCa cell lines in vitro with combined Pter and low dose SAHA resulted in more potent inhibition of MTA1/HIF-1α than by high dose SAHA alone. Our study provides preclinical evidence that Pter/SAHA combination treatment inhibits MTA1/HIF-1α tumor-promoting signaling in PCa. The beneficial outcome of combinatorial strategy using a natural agent and an approved drug for higher efficacy and less toxicity supports further development of MTA1-targeted therapies in PCa.

Unconstraining Methods in Revenue Management Systems: Research Overview and Prospects

Abstract: Demand unconstraining is one of the key techniques to the success of revenue management systems. This paper surveys the history of research on unconstraining methods and reviews over 130 references including the latest research works in the area. We discuss the relationship between censored data unconstraining and forecasting and review five alternative unconstraining approaches. These methods consider data unconstraining in various situations such as single-class, multi-class, and multi-flight. The paper also proposes some future research questions to bridge the gap between theory and applications.