Showing papers by "Long Island University published in 2014"

Comparative abilities of Microsoft Kinect and Vicon 3D motion capture for gait analysis.

Abstract: Biomechanical analysis is a powerful tool in the evaluation of movement dysfunction in orthopaedic and neurologic populations. Three-dimensional (3D) motion capture systems are widely used, accurate systems, but are costly and not available in many clinical settings. The Microsoft Kinect™ has the potential to be used as an alternative low-cost motion analysis tool. The purpose of this study was to assess concurrent validity of the Kinect™ with Brekel Kinect software in comparison to Vicon Nexus during sagittal plane gait kinematics. Twenty healthy adults (nine male, 11 female) were tracked while walking and jogging at three velocities on a treadmill. Concurrent hip and knee peak flexion and extension and stride timing measurements were compared between Vicon and Kinect™. Although Kinect measurements were representative of normal gait, the Kinect™ generally under-estimated joint flexion and over-estimated extension. Kinect™ and Vicon hip angular displacement correlation was very low and error was large. Kinect™ knee measurements were somewhat better than hip, but were not consistent enough for clinical assessment. Correlation between Kinect™ and Vicon stride timing was high and error was fairly small. Variability in Kinect™ measurements was smallest at the slowest velocity. The Kinect™ has basic motion capture capabilities and with some minor adjustments will be an acceptable tool to measure stride timing, but sophisticated advances in software and hardware are necessary to improve Kinect™ sensitivity before it can be implemented for clinical use.

Specimen collection: An essential tool

Abstract: Collecting biological specimens for scientific studies came under scrutiny when B. A. Minteer et al. [“Avoiding (re)extinction,” Perspectives, 18 April, p. [260][1]] suggested that this practice plays a significant role in species extinctions. Based on a small number of examples (rare birds,

Narcissistic Grandiosity and Narcissistic Vulnerability in Psychotherapy

Abstract: This article briefly summarizes the empirical and clinical literature underlying a contemporary clinical model of pathological narcissism. Unlike the DSM Narcissistic Personality Disorder (NPD), this clinical model identifies and differentiates between two phenotypic themes of dysfunction—narcissistic grandiosity and narcissistic vulnerability—that can be expressed both overtly and covertly in patients’ ways of thinking, feeling, behaving, and participating in treatment. Clinical recognition that narcissistic patients can and often do present for psychotherapy in vulnerable states of depression, anxiety, shame, and even suicidality increases the likelihood of accurate diagnosis and effective treatment planning. This article provides case examples derived from psychotherapies with narcissistic patients to demonstrate how narcissistic grandiosity and narcissistic vulnerability concurrently present in patients who seek treatment.

Holographic thermalization, stability of anti-de sitter space, and the Fermi-Pasta-Ulam paradox.

Abstract: For a real massless scalar field in general relativity with a negative cosmological constant, we uncover a large class of spherically symmetric initial conditions that are close to anti--de Sitter space (AdS) but whose numerical evolution does not result in black hole formation. According to the AdS/conformal field theory (CFT) dictionary, these bulk solutions are dual to states of a strongly interacting boundary CFT that fail to thermalize at late times. Furthermore, as these states are not stationary, they define dynamical CFT configurations that do not equilibrate. We develop a two-time-scale perturbative formalism that captures both direct and inverse cascades of energy and agrees with our fully nonlinear evolutions in the appropriate regime. We also show that this formalism admits a large class of quasiperiodic solutions. Finally, we demonstrate a striking parallel between the dynamics of AdS and the classic Fermi-Pasta-Ulam-Tsingou problem.

Possible Loss of the Chloroplast Genome in the Parasitic Flowering Plant Rafflesia lagascae (Rafflesiaceae)

Abstract: Rafflesia is a genus of holoparasitic plants endemic to Southeast Asia that has lost the ability to undertake photosynthesis. With short-read sequencing technology, we assembled a draft sequence of the mitochondrial genome of Rafflesia lagascae Blanco, a species endemic to the Philippine island of Luzon, with ~350 sequencing depth coverage. Using multiple approaches, however, we were only able to identify small fragments of plastid sequences at low coverage depth (<2) and could not recover any substantial portion of a chloroplast genome. The gene fragments we identified included photosynthesis and energy production genes (atp,ndh,pet,psa,psb,rbcL), ribosomal RNA genes (rrn16,rrn23), ribosomal protein genes (rps7,rps11,rps16), transfer RNA genes, as well as matK,accD,ycf2, and multiple nongenic regions from the inverted repeats. None of the identified plastid gene sequences had intact reading frames. Phylogenetic analysis suggests that ~33% of these remnant plastid genes may have been horizontally transferred from the host plant genus Tetrastigma with the rest having ambiguous phylogenetic positions (<50% bootstrap support), except for psaB that was strongly allied with the plastid homolog in Nicotiana. Our inability to identify substantial plastid genome sequences from R. lagascae using multiple approaches—despite success in identifying and developing a draft assembly of the much larger mitochondrial genome—suggests that the parasitic plant genus Rafflesia may be the first plant group for which there is no recognizable plastid genome, or if presen ti s found in cryptic form at very low levels.

Is This Opinion Leader's Review Useful? Peripheral Cues for Online Review Helpfulness

Abstract: With the growing popularity of online user-generated reviews, research has emerged to understand the mechanism of how a review is voted helpful, focusing on the central-route influences of review content and quality, yet little research has studied the roles of peripheral cues such as reviewer credibility and contextual factors. Drawing on the theories of elaboration likelihood model and source credibility model, this study developed an integrative model of online review helpfulness, focusing on the direct influence of reviewer credibility and the moderating effects of service price and rating extremity. An econometrics regression analysis of 16,265 hotel reviews on Yelp showed that reviewer expertise in terms of the number of “Elite” badges, and reviewer online attractiveness in terms of the number of friends both helped a review receive helpfulness votes. The findings further revealed that a review written by an opinion leader (i.e., a reviewer with more Elite badges and more online friends) did not necessarily receive more helpfulness votes. Hotel price weakened the enhancing effect of reviewer expertise. Rating extremity also diluted the influence of reviewer credibility. These findings contribute to the knowledge of online review helpfulness, and offer practical implications on how to position valuable reviews.

Magnetized Neutron Stars With Realistic Equations of State and Neutrino Cooling

Abstract: We incorporate realistic, tabulated equations of state into fully relativistic simulations of magnetized neutron stars along with a neutrino leakage scheme which accounts for cooling via neutrino emission. Both these improvements utilize open-source code (GR1D) and tables from the Web site stellarcollapse.org. Our implementation makes use of a novel method for the calculation of the optical depth, which simplifies its use with distributed adaptive mesh refinement. We present various tests with and without magnetization and preliminary results both from single stars and from the merger of a binary system.

Comparison of Landing Biomechanics Between Male and Female Dancers and Athletes, Part 2 Influence of Fatigue and Implications for Anterior Cruciate Ligament Injury

Abstract: Background:Fatigue is strongly linked to an increased risk of injuries, including anterior cruciate ligament (ACL) ruptures. Part 1 of this study identified differences in the biomechanics of landing from a jump between dancers and team athletes, particularly female athletes, which may explain the epidemiological differences in ACL injuries between dancers and team athletes and the lack of a sex disparity within dancers. However, it is not known if these biomechanical variables change differently between team athletes and dancers in the face of fatigue.Purpose/Hypothesis:The purpose of this study was to compare dancers’ and team athletes’ resistance to fatigue and its effect on the biomechanics of single-legged drop landings. The primary hypotheses were that dancers may be more resistant than team athletes to the onset of fatigue and/or may have different biomechanical responses than athletes in landing tasks once fatigue has been achieved.Study Design:Controlled laboratory study.Methods:Kinematics and ki...

Finding disseminators via electronic word of mouth message for effective marketing communications

Abstract: It has become increasingly important for companies to utilize electronic word of mouth (eWOM) in their marketing campaigns for desired product sales. Identifying key eWOM disseminators among consumers is a challenge for companies. WOM is an interpersonal communication in which a sender spreads a message to receivers. Previously, researchers and practitioners have searched for opinion leaders by examining senders and receivers due to limited records on WOM message. Our study identifies three types of opinion leaders through eWOM using a message-based approach that elicits more accurate and comprehensive information on opinion leadership than sender-based and receiver-based approaches. We demonstrate that eWOM of opinion leaders drives product sales due to their product experience and knowledge background. Our findings suggest that companies can increase product sales via effective use of eWOM of such opinion leaders. Managerial and marketing implications are addressed. We identify disseminators for effective marketing campaign by using eWOM message.Our approach identifies more accurate and comprehensive opinion leadership.Opinion leaders' eWOM influences product sales through product experience effects.Opinion leaders' eWOM influences product sales through knowledge background effects.Firms need disseminators with individually broad and collectively focused knowledge.

Comparison of Landing Biomechanics Between Male and Female Dancers and Athletes, Part 1 Influence of Sex on Risk of Anterior Cruciate Ligament Injury

Abstract: Background:The incidence of anterior cruciate ligament (ACL) injuries among dancers is much lower than among team sport athletes, and no clear disparity between sexes has been reported in the dance population. Although numerous studies have observed differences in landing biomechanics of the lower extremity between male and female team sport athletes, there is currently little research examining the landing biomechanics of male and female dancers and none comparing athletes to dancers. Comparing the landing biomechanics within these populations may help explain the lower overall ACL injury rates and lack of sex disparity.Hypothesis:The purpose was to compare the effects of sex and group (dancer vs team sport athlete) on single-legged drop-landing biomechanics. The primary hypothesis was that female dancers would perform a drop-landing task without demonstrating typical sex-related risk factors associated with ACL injuries. A secondary hypothesis was that female team sport athletes would display typical AC...

Curbing Craving Behavioral and Brain Evidence That Children Regulate Craving When Instructed to Do So but Have Higher Baseline Craving Than Adults

Abstract: Although one third of children and adolescents are overweight or obese, developmental changes in food craving and the ability to regulate craving remain poorly understood. We addressed this knowledge gap by examining behavioral and neural responses to images of appetizing unhealthy foods in individuals ages 6 through 23 years. On close trials (assessing unregulated craving), participants focused on a pictured food's appetitive features. On far trials (assessing effortful regulation), participants focused on a food's visual features and imagined that it was farther away. Across conditions, older age predicted less craving, less striatal recruitment, greater prefrontal activity, and stronger frontostriatal coupling. When effortfully regulating their responses to the images, all participants reported less craving and exhibited greater recruitment of lateral prefrontal cortex and less recruitment of ventromedial prefrontal cortex. Greater body mass predicted less regulation-related prefrontal activity, particularly among children. These results suggest that children experience stronger craving than adults but can also effectively regulate craving. Moreover, the mechanisms underlying regulation may differ for heavy and lean children.

Attachment and mentalization in female patients with comorbid narcissistic and borderline personality disorder.

Abstract: We investigated attachment representations and the capacity for mentalization in a sample of adult female borderline patients with and without comorbid narcissistic personality disorder (NPD). Participants were 22 borderline patients diagnosed with comorbid NPD (NPD/BPD) and 129 BPD patients without NPD (BPD) from 2 randomized clinical trials. Attachment and mentalization were assessed on the Adult Attachment Interview (AAI; George, Kaplan, & Main, 1996). Results showed that as expected, compared with the BPD group, the NPD/BPD group was significantly more likely to be categorized as either dismissing or cannot classify on the AAI, whereas the BPD group was more likely to be classified as either preoccupied or unresolved for loss and abuse than was the NPD/BPD group. Both groups of patients scored low on mentalizing, and there were no significant differences between the groups, indicating that both NPD/BPD and BPD individuals showed deficits in this capacity. The clinical implications of the group differences in AAI classification are discussed with a focus on how understanding the attachment representations of NPD/BPD patients helps to illuminate their complex, contradictory mental states.

Higher Hochschild Homology, Topological Chiral Homology and Factorization Algebras

Abstract: We study the higher Hochschild functor, factorization algebras and their relationship with topological chiral homology. To this end, we emphasize that the higher Hochschild complex is a functor sSet∞ × CDGA∞ where sSet and CDGA∞ are the (∞,1)-categories of simplicial sets and commutative differential graded algebras, and give an axiomatic characterization of this functor. From the axioms, we deduce several properties and computational tools for this functor. We study the relationship between the higher Hochschild functor and factorization algebras by showing that, in good cases, the Hochschild functor determines a constant commutative factorization algebra. Conversely, every constant commutative factorization algebra is naturally equivalent to a Hochschild chain factorization algebra. Similarly, we study the relationship between the above concepts and topological chiral homology. In particular, we show that on their common domains of definition, the higher Hochschild functor is naturally equivalent to topological chiral homology. Finally, we prove that topological chiral homology determines a locally constant factorization algebra and, further, that this functor induces an equivalence between locally constant factorization algebras on a manifold and (local system of) En-algebras.

Simulating the universe(s): from cosmic bubble collisions to cosmological observables with numerical relativity

Abstract: The theory of eternal inflation in an inflaton potential with multiple vacua predicts that our universe is one of many bubble universes nucleating and growing inside an ever-expanding false vacuum. The collision of our bubble with another could provide an important observational signature to test this scenario. We develop and implement an algorithm for accurately computing the cosmological observables arising from bubble collisions directly from the Lagrangian of a single scalar field. We first simulate the collision spacetime by solving Einstein's equations, starting from nucleation and ending at reheating. Taking advantage of the collision's hyperbolic symmetry, the simulations are performed with a 1+1-dimensional fully relativistic code that uses adaptive mesh refinement. We then calculate the comoving curvature perturbation in an open Friedmann-Robertson-Walker universe, which is used to determine the temperature anisotropies of the cosmic microwave background radiation. For a fiducial Lagrangian, the anisotropies are well described by a power law in the cosine of the angular distance from the center of the collision signature. For a given form of the Lagrangian, the resulting observational predictions are inherently statistical due to stochastic elements of the bubble nucleation process. Further uncertainties arise due to our imperfect knowledge about inflationary and pre-recombination physics. We characterize observational predictions by computing the probability distributions over four phenomenological parameters which capture these intrinsic and model uncertainties. This represents the first fully-relativistic set of predictions from an ensemble of scalar field models giving rise to eternal inflation, yielding significant differences from previous non-relativistic approximations. Thus, our results provide a basis for a rigorous confrontation of these theories with cosmological data.

Stopping Overshopping: A Preliminary Randomized Controlled Trial of Group Therapy for Compulsive Buying Disorder

Abstract: The present study tested the efficacy of a group treatment model for compulsive buying disorder, the Stopping Overshopping model, which includes aspects of cognitive-behavioral and dialectical behavior therapy, psychodynamic psychotherapy, psychoeducation, motivational interviewing, acceptance and commitment therapy, and mindfulness. A randomized controlled trial with 11 participants compared the efficacy of this model with a waiting-list control group, which received the treatment after a 12-week waiting period. Results showed significant improvement on (a) all compulsive buying measures, (b) amount of money and time spent, and (c) number of compulsive shopping episodes, all of which were well maintained at 6-month follow-up.

Discovery of novel mutations for clarithromycin resistance in Helicobacter pylori by using next-generation sequencing

Abstract: Objectives Resistance to clarithromycin is the most important factor causing failure of Helicobacter pylori eradication. Although clarithromycin resistance is mainly associated with three point mutations in the 23S rRNA genes, it is unclear whether other mutations are associated with this resistance.

Interaction of misaligned magnetospheres in the coalescence of binary neutron stars

Abstract: We study the dependence of the electromagnetic luminosity---produced by interactions of force-free magnetospheres---on dipole inclinations in binary neutron star systems. We show that this interaction extracts kinetic energy from the system and powers a Poynting flux with a strong dependence on the dipole orientations. This dependence can be linked to the reconnection and redistribution of the magnetic field as the stars interact. Although the details of the Poynting luminosity are very much dependent on the orientation, all the cases considered here nevertheless radiate a large Poynting flux. This robust emission suggests that the premerger stage of binary neutron star systems can yield interesting electromagnetic counterparts to gravitational wave events.

A Randomized Controlled Trial Comparing the Effects of Yoga With an Active Control on Ambulatory Blood Pressure in Individuals With Prehypertension and Stage 1 Hypertension

Abstract: The purpose of this study was to compare the effects of yoga with an active control (nonaerobic exercise) in individuals with prehypertension and stage 1 hypertension. A randomized clinical trial was performed using two arms: (1) yoga and (2) active control. Primary outcomes were 24-hour day and night ambulatory systolic and diastolic blood pressures. Within-group and between-group analyses were performed using paired t tests and repeated-measures analysis of variance (time × group), respectively. Eighty-four participants enrolled, with 68 participants completing the trial. Within-group analyses found 24-hour diastolic, night diastolic, and mean arterial pressure all significantly reduced in the yoga group (-3.93, -4.7, -4.23 mm Hg, respectively) but no significant within-group changes in the active control group. Direct comparisons of the yoga intervention with the control group found a single blood pressure variable (diastolic night) to be significantly different (P=.038). This study has demonstrated that a yoga intervention can lower blood pressure in patients with mild hypertension. Although this study was not adequately powered to show between-group differences, the size of the yoga-induced blood pressure reduction appears to justify performing a definitive trial of this intervention to test whether it can provide meaningful therapeutic value for the management of hypertension.

Diacylglycerol lipase regulates lifespan and oxidative stress response by inversely modulating TOR signaling in Drosophila and C. elegans

Abstract: Target of rapamycin (TOR) signaling is a nutrient-sensing pathway controlling metabolism and lifespan. Although TOR signaling can be activated by a metabolite of diacylglycerol (DAG), phosphatidic acid (PA), the precise genetic mechanism through which DAG metabolism influences lifespan remains unknown. DAG is metabolized to either PA via the action of DAG kinase or 2-arachidonoyl-sn-glycerol by diacylglycerol lipase (DAGL). Here, we report that in Drosophila and Caenorhabditis elegans, overexpression of diacylglycerol lipase (DAGL/inaE/dagl-1) or knockdown of diacylglycerol kinase (DGK/rdgA/dgk-5) extends lifespan and enhances response to oxidative stress. Phosphorylated S6 kinase (p-S6K) levels are reduced following these manipulations, implying the involvement of TOR signaling. Conversely, DAGL/inaE/dagl-1 mutants exhibit shortened lifespan, reduced tolerance to oxidative stress, and elevated levels of p-S6K. Additional results from genetic interaction studies are consistent with the hypothesis that DAG metabolism interacts with TOR and S6K signaling to affect longevity and oxidative stress resistance. These findings highlight conserved metabolic and genetic pathways that regulate aging.

Masculine Status, Sexual Performance, and the Sexual Stigmatization of Women

Abstract: Collegiate hookup culture advances ideas of masculinity but contradicts notions of appropriate feminine sexuality. Drawing on focus group and interview data with college students, I examine how a group of class- and race-privileged fraternity men face dilemmas as they enact a group constructed masculinity focused on sexual performance and the objectification of women. I employ a symbolic interactionist framework to illustrate how men, attentive to peer status yet anxious about the sexual stigmatization of women, draw on cultural ideas about appropriate feminine sexuality as they account for their approaches to sex and women (both with whom they interact sexually and how) along a range of intimacy—from hookups to committed relationships. I demonstrate that heterosexual interaction does not unequivocally link to masculine status and that men sometimes strive to limit the impact of casual sex or avoid it altogether.

What's Gender Got to Do with It? A Critique of RDA 9.7

Abstract: The Library of Congress (LC) and the Program for Cooperative Cataloging (PCC) interpretation of Resource Description and Access (RDA) 9.7 regarding gender when identifying persons reinforces regressive conceptions of gender identity. The rule instructs catalogers to record gender when identifying persons, and although RDA gives catalogers the flexibility to record more than two gender labels, LC limits Name Authority Cooperative Program (NACO) catalogers to a binary label: male, female, or not known. In this article, the authors challenge gender as a descriptive attribute for personal names, critique how LC is instructing NACO catalogers to record elements about gender, and make recommendations to address describing persons in LC authority records.

Energy drink consumption and associated health behaviors among university students in an urban setting.

Abstract: The objective of this study is to describe energy drink consumption and health behaviors among college students attending a predominantly minority university. Undergraduate and graduate students attending a private, minority-serving university were invited to participate in an online survey between September 2009 and August 2010. Out of 2,500 students, 407 participated yielding a response of 16 %. Analysis assessed energy drink consumption as well as participation in sport activities and high-risk behaviors. Energy drink consumption is significantly related with drinking alcohol to inebriation and driving (r = .14, p < .05) and to riding with a drunk driver (r = .15, p < .05). Athletes were more likely to engage in drinking alcohol to inebriation and driving F (1, 186) = 6.12, p < .02. Energy drink consumption is a common practice among racial minority university students. Tailored health promotion strategies and interventions are needed to address misconceptions of energy drink and alcohol mixing.

Differential expressions of the alternatively spliced variant mRNAs of the µ opioid receptor gene, OPRM1, in brain regions of four inbred mouse strains.

Abstract: The µ opioid receptor gene, OPRM1, undergoes extensive alternative pre-mRNA splicing in rodents and humans, with dozens of alternatively spliced variants of the OPRM1 gene. The present studies establish a SYBR green quantitative PCR (qPCR) assay to more accurately quantify mouse OPRM1 splice variant mRNAs. Using these qPCR assays, we examined the expression of OPRM1 splice variant mRNAs in selected brain regions of four inbred mouse strains displaying differences in µ opioid-induced tolerance and physical dependence: C56BL/6J, 129P3/J, SJL/J and SWR/J. The complete mRNA expression profiles of the OPRM1 splice variants reveal marked differences of the variant mRNA expression among the brain regions in each mouse strain, suggesting region-specific alternative splicing of the OPRM1 gene. The expression of many variants was also strain-specific, implying a genetic influence on OPRM1 alternative splicing. The expression levels of a number of the variant mRNAs in certain brain regions appear to correlate with strain sensitivities to morphine analgesia, tolerance and physical dependence in four mouse strains.

Stochastic efficiency analysis with a reliability consideration

Abstract: Stochastic Data Envelopment Analysis (DEA) models have been introduced in the literature to assess the performance of operating entities with random input and output data. A stochastic DEA model with a reliability constraint is proposed in this study that maximizes the lower bound of an entity׳s efficiency score with some pre-selected probability. We define the concept of stochastic efficiency and develop a solution procedure. The economic interpretations of the stochastic efficiency index are presented when the inputs and outputs of each entity follow a multivariate joint normal distribution.

Detection of radio emission from fireballs

Abstract: We present the findings from the Prototype All-Sky Imager, a back end correlator of the first station of the Long Wavelength Array, which has recorded over 11,000 hr of all-sky images at frequencies between 25 and 75 MHz. In a search of this data for radio transients, we have found 49 long-duration (10 s of seconds) transients. Ten of these transients correlate both spatially and temporally with large meteors (fireballs), and their signatures suggest that fireballs emit a previously undiscovered low frequency, non-thermal pulse. This emission provides a new probe into the physics of meteors and identifies a new form of naturally occurring radio transient foreground.

Predicting Social Work Students’ Interest in Gerontology: Results From an International Sample

Abstract: The need for social workers with a specialization in gerontology has become a global priority. The purpose of this study was to explore social work students' interest in gerontology. This cross-sectional survey was completed by 1,042 students from the United States, England, and Australia, and only 5.4% of the sample indicated an interest in gerontology. Results of the logistic regression found that personal aging beliefs and the frequency of time spent with an older adult were significant in explaining gerontological interest. The infusion of aging content may facilitate further advancement in the field, but additional strategies may also be needed.

United States Adults Meeting 2010 American College of Rheumatology Criteria for Treatment and Prevention of Glucocorticoid‐Induced Osteoporosis

Abstract: Objective The American College of Rheumatology (ACR) updated its guidelines on the prevention and treatment of glucocorticoid-induced osteoporosis (GIO) in 2010. An unknown proportion of US adults at risk of fracture due to glucocorticoid use would be recommended antiosteoporosis pharmaceutical (AOP) therapies based on the ACR guidelines. Methods Using the 2005–2010 National Health and Nutrition Examination Survey (NHANES) data for postmenopausal women (PMW), and men age ≥50 years reporting current glucocorticoid use, we categorized individuals according to ACR criteria for low, medium, and high fracture risk (<10%, ≥10%, and ≥20%, respectively) and provided percentages of treatment recommendations for chronic (≥90 days) medium and all high-risk patients. Results Glucocorticoids were used by 1.66% of PMW and 1.65% of men age ≥50 years. Of these patients, 0.80% of PMW and 0.45% of men age ≥50 years were at high risk of fracture. A majority of PMW (81.2%) and men age ≥50 years (75.8%) were chronic glucocorticoid users. In patients for whom treatment recommendations could be made, 64.9% of PMW and 51.9% of men age ≥50 years would be recommended therapy, but only 28.4% of PMW and 9.7% of men age ≥50 years reported AOP use. Conclusion Based on the NHANES (2005–2010) data, we estimate glucocorticoid use in >1.5 million US PMW and men age ≥50 years. Treatment would be recommended in at least 50% of this population based on the 2010 ACR guidelines. Self-reported AOP use was documented in <30%, suggesting a treatment gap in the management of GIO in the US before the guideline release.