Nalco Holding Company

About: Nalco Holding Company is a based out in . It is known for research contribution in the topics: Corrosion & Aqueous solution. The organization has 2375 authors who have published 3056 publications receiving 51473 citations.

Coating to prevent the oxidation of electrodes during electric furnace steel making

Abstract: A coating is provided which substantially lengthens the life of carbon and graphite electrodes used in electrical arc processes for the manufacture of ferrous metals The coating forms a silica-phosphorus glass upon the electrodes

Activation of STAT5-cyclin D1 Pathway in Chewing Tobacco Mediated Oral Squamous Cell Carcinoma

Abstract: Cyclin D1 overexpression and upregulation has been reported largely in Oral Squamous Cell Carcinoma (OSCC) but the mechanism behind it is not clear. Here, the transcription and translational upregulation of cyclin D1 was observed in most of the tobacco chewing oral cancer patients where as the gene amplification was limited to only small group (20%) of patients. A transcription factor (TF) binding site has been detected from −483 to −451 by using DNase I foot printing analysis and confirmed by electrophoretic mobility shift assay by using oral tumour nuclear extract (NE). This is a STAT binding sequence and confirmed as STAT5a by supershift assay. The binding of STAT5 was observed in 80% (24/30) oral cancer samples. The co-expression of cyclin D1 with STAT5 binding was observed in 90% (27/30) of the samples. STAT family of proteins is emerging to play role in oral carcinogenesis. Here, the binding of STAT5 might up regulate cyclin D1 in most of the samples whereas; the gene amplification events are sporadic in oral carcinogenesis. Our study provides the first evidence of the constitutive activation of STAT5-cyclin D1 pathway in chewing tobacco mediated OSCC.

Method of treating paper and textiles with organically modified sio' 2 'aquasols

Abstract: Novel silica aquasols ranging in concentration from about 30 to 60% SiO2 which are organically modified by a double coating of a water-dispersible or water-soluble long hydrocarbon chain quaternary ammonium compound and the method of making same. The products retain strength and frictionizing properties found generally beneficial in silica sols and add softness and antistatic properties to paper and textiles treated with these products.

Rolling Circle cDNA Synthesis Uncovers Circular RNA Splice Variants.

Abstract: High-throughput RNA sequencing and novel bioinformatic pipelines have identified thousands of circular (circ)RNAs containing backsplice junction sequences. However, circRNAs generated from multiple exons may contain different combinations of exons and/or introns arising from alternative splicing, while the backsplice junction sequence is the same. To be able to identify circRNA splice variants, we developed a method termed circRNA-Rolling Circle Amplification (circRNA-RCA). This method detects full-length circRNA sequences by performing reverse transcription (RT) in the absence of RNase H activity, followed by polymerase chain reaction (PCR) amplification of full-length circRNAs using a forward primer spanning the backsplice junction sequence and a reverse primer exactly upstream of the forward primer. By sequencing the PCR products, circRNA splice variants bearing the same backsplice junctions, which were otherwise only predicted computationally, could be experimentally validated. The splice variants were further predicted to associate with different subsets of target RNA-binding proteins and microRNAs, supporting the notion that different circRNA splice variants can have different biological impacts. In sum, the circRNA-RCA method allows the accurate identification of full-length circRNA sequences, offering unique insight into their individual function.