Ocean University of China

About: Ocean University of China is a education organization based out in Qingdao, China. It is known for research contribution in the topics: Population & Sea surface temperature. The organization has 27604 authors who have published 27886 publications receiving 440181 citations. The organization is also known as: Zhōngguó Hǎiyáng Dàxué & OUC.

Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease.

Abstract: Increasing evidence has shown the aberrant expression of inflammasome-related proteins in Alzheimer's disease (AD) brain; these proteins, including NLRP1 inflammasome, are implicated in the execution of inflammatory response and pyroptotic death Although current data are associated NLRP1 genetic variants with AD, the involvement of NLRP1 inflammasome in AD pathogenesis is still unknown Using APPswe/PS1dE9 transgenic mice, we found that cerebral NLRP1 levels were upregulated Our in vitro studies further showed that increased NLRP1-mediated caspase-1-dependent ‘pyroptosis' in cultured cortical neurons in response to amyloid-β Moreover, we employed direct in vivo infusion of non-viral small-interfering RNA to knockdown NLRP1 or caspase-1 in APPswe/PS1dE9 brain, and discovered that these NLRP1 or caspase-1 deficiency mice resulted in significantly reduced neuronal pyroptosis and reversed cognitive impairments Taken together, our findings indicate an important role for NLRP1/caspase-1 signaling in AD progression, and point to the modulation of NLRP1 inflammasome as a promising strategy for AD therapy

Effects of solution chemistry on adsorption of selected pharmaceuticals and personal care products (PPCPs) by graphenes and carbon nanotubes.

Abstract: Adsorption of three selected pharmaceuticals and personal care products (PPCPs) (ketoprofen (KEP), carbamazepine (CBZ), and bisphenol A (BPA)) by two reduced graphene oxides (rGO1 and rGO2) and one commercial graphene was examined under different solution conditions. Single-walled carbon nanotubes (SWCNTs), multiwalled carbon nanotubes (MWCNTs), and powdered graphite were also investigated for comparison. All adsorption isotherms followed the order of SWCNTs > rGO1 > rGO2 > MWCNTs > graphene > graphite, consistent with the orders of their surface areas and micropore volumes. After surface area normalization, adsorption affinities of the three PPCPs onto graphenes were lower than onto graphite, suggesting incomplete occupation for adsorption sites because of the aggregation of graphene sheets and the presence of oxygen-containing functional groups. The observed pH effects on adsorption correlated well with the pH-regulated distribution of the protonated neutral species of the three PPCPs. Increasing ionic ...

A facile nanocomposite strategy to fabricate a rGO–MWCNT photothermal layer for efficient water evaporation

Abstract: Solar-driven water evaporation assisted by photothermal membranes is considered as one of the sustainable and cost-effective strategies for pure water generation and wastewater treatment. Herein, we report a facile but effective approach to improve the photothermal performance by combining 2D reduced graphene oxide (rGO) and 1D multi-walled carbon nanotubes (MWCNTs), which have different nanomorphologies. The photothermal layer can be easily deposited on different substrate materials via simple vacuum assistance. Such a composite photothermal layer shows a rough surface with a controllable nano-structure, which can thus optimize solar light harvesting. On the other hand, the formation of a loose internal porous structure and suitable wettability ensure water transport inside the photothermal layer during evaporation. The surface temperature reaches as high as 78 °C even under one sun irradiation (1 kW m−2), which is 10 °C higher than the result of pure rGO membranes. When loaded on a PVDF substrate, the rGO–MWCNT based membrane is flexible and shows an obvious improvement in the evaporation rate, about 79.0% and 8.9% higher than those of pure rGO and MWCNT membranes, respectively. The solar thermal conversion efficiency can reach up to 80.4% without any extra accessory for thermal management. Based on our results, the nanocomposite strategy is facile and effective for the development of novel photothermal membranes for high-efficiency evaporation, and contributes to the widespread application in the fields of desalination and wastewater treatment.

Self-assembly of block copolymers towards mesoporous materials for energy storage and conversion systems

Abstract: Self-assembly of block copolymers (BCPs) provides a versatile strategy for controllable preparation of a broad range of functional materials with different ordered structures. In recent decades, this soft-templating strategy has been widely utilized for preparing a wide range of mesoporous materials. These porous materials have attracted tremendous interest in energy storage and conversion (ESC) applications in view of their ability to absorb, store, and interact with guest species on their exterior/interior surfaces and in the pore space. Compared with other synthetic approaches, such as template-free and hard-templating methods, BCP soft-templating protocols show great advantages in the construction of large mesopores with diameters between 10-60 nm, which are suitable for applications requiring the storage or hosting of large-sized species/molecules. In addition, this strategy shows incomparable merits in the flexible control of pore size/architecture/wall thickness, which determines the final performance of mesoporous materials in ESC devices. In the last decade, rapid development has been witnessed in the area of BCP-templated mesoporous materials. In this review paper, we overview the progress of this field over the past 10 years, with an emphasis on the discussions of synthetic methodologies, the control of materials structures (including morphology and pore size/shape), and potential applications particularly in rechargeable batteries, supercapacitors, electro-/photocatalysis, solar cells, etc.