Institution
Ocean University of China
Education•Qingdao, China•
About: Ocean University of China is a education organization based out in Qingdao, China. It is known for research contribution in the topics: Population & Sea surface temperature. The organization has 27604 authors who have published 27886 publications receiving 440181 citations. The organization is also known as: Zhōngguó Hǎiyáng Dàxué & OUC.
Topics: Population, Sea surface temperature, Gene, Chemistry, Adsorption
Papers published on a yearly basis
Papers
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30 Dec 2008-Species diversity : an international journal for taxonomy, systematics, speciation, biogeography, and life history research of animals
103 citations
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TL;DR: EPA-PL supplementation was efficacious in suppressing body fat accumulation, and alleviating insulin resistance and hepatic steatosis by modulating the secretion of adipocytokines and inflammatory cytokines, suppression of SREBP-1c mediated lipogenesis and enhancement of fatty acid β-oxidation.
Abstract: Over the past two decades, a striking increase in the number of people with metabolic syndrome (MS) has taken place worldwide. With the elevated risk of not only diabetes but also cardiovascular morbidity and mortality, there is urgent need for strategies to prevent this emerging global epidemic. The present study was undertaken to investigate the effects of dietary eicosapentaenoic acid-enriched phospholipid (EPA-PL) on metabolic disorders. Male C57BL/6J mice (n = 7) were fed one of the following 4 diets for a period of 4 weeks: 1) a modified AIN-96G diet with 5% corn oil (control diet); 2) a high fat (20%, wt/wt) and high fructose (20%, wt/wt) diet (HF diet); 3) the HF diet containing 1% SOY-PL (SOY-PL diet); 4) the HF diet containing 1% EPA-PL (EPA-PL diet). The oral glucose tolerance test was performed. Plasma TG, TC, glucose, NEFA, insulin, leptin, adiponectin, TNF-α and IL-6 levels were assessed. In addition, hepatic lipid levels, lipogenic, and lipidolytic enzyme activities and gene expressions were evaluated. Both EPA-PL and SOY-PL significantly inhibited body weight gain and white adipose tissue accumulation, alleviated glucose intolerance, and lowered both serum fasting glucose and NEFA levels substantially. Only EPA-PL significantly reduced serum TNF-α and IL-6 levels, and increased serum adiponectin level. EPA-PL was more effective in reducing hepatic and serum TG and TC levels than SOY-PL. Both EPA-PL and SOY-PL reduced the activities of hepatic lipogenic enzymes, such as FAS and G6PDH, but only EPA-PL significantly increased CPT, peroxisomal β-oxidation enzymes activities and CPT-1a mRNA level. Alterations of hepatic lipogenic gene expressions, such as FAS, G6PDH, ACC, SCD-1 and SREBP-1c were consistent with changes in related enzyme activities. According to our study, EPA-PL supplementation was efficacious in suppressing body fat accumulation, and alleviating insulin resistance and hepatic steatosis by modulating the secretion of adipocytokines and inflammatory cytokines, suppression of SREBP-1c mediated lipogenesis and enhancement of fatty acid β-oxidation. These results demonstrate that EPA-PL is a novel beneficial food component for the prevention and improvement of metabolic disorders.
103 citations
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TL;DR: This review summarizes the recent studies in cell cultures and animal models, mainly discusses the molecular mechanisms of the neuroprotective effects of resveratrol, and investigates the therapeutic potential in AD.
Abstract: Alzheimer's disease (AD) is the most common cause of dementia, but there is no effective therapy till now. The pathogenic mechanisms of AD are considerably complex, including Aβ accumulation, tau protein phosphorylation, oxidative stress, and inflammation. Exactly, resveratrol, a polyphenol in red wine and many plants, is indicated to show the neuroprotective effect on mechanisms mostly above. Recent years, there are numerous researches about resveratrol acting on AD in many models, both in vitro and in vivo. However, the effects of resveratrol are limited by its pool bioavailability; therefore researchers have been trying a variety of methods to improve the efficiency. This review summarizes the recent studies in cell cultures and animal models, mainly discusses the molecular mechanisms of the neuroprotective effects of resveratrol, and thus investigates the therapeutic potential in AD.
103 citations
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TL;DR: It was found that some properties of the enzymes from the marine yeasts are unique compared to those of the homologous enzymes from terrestrial yeasts and the genes encoding the enzymes in marineYeasts are different from those in terrestrialYeasts.
103 citations
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TL;DR: In this article, a two-stage Triassic exhumation model was proposed for the Dabie orogen, which combines the early southeastward vertical extrusion with the later southeastward lateral extrusion.
102 citations
Authors
Showing all 27836 results
Name | H-index | Papers | Citations |
---|---|---|---|
Guangming Zeng | 146 | 1676 | 100743 |
Bin Wang | 126 | 2226 | 74364 |
Simon A. Wilde | 118 | 390 | 45547 |
Yusuke Yamauchi | 117 | 1000 | 51685 |
Xiaoming Li | 113 | 1932 | 72445 |
Baoshan Xing | 109 | 823 | 48944 |
Peng Wang | 108 | 1672 | 54529 |
Jun Yang | 107 | 2090 | 55257 |
Shang-Ping Xie | 105 | 441 | 36437 |
M. Santosh | 103 | 1344 | 49846 |
Qi Li | 102 | 1563 | 46762 |
Wei Liu | 102 | 2927 | 65228 |
Tao Wang | 97 | 2720 | 55280 |
Wei Wang | 95 | 3544 | 59660 |
Peng Li | 95 | 1548 | 45198 |