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Showing papers by "Sofia University published in 2017"


Journal ArticleDOI
Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1, Ece Aşılar1  +2212 moreInstitutions (157)
TL;DR: A fully-fledged particle-flow reconstruction algorithm tuned to the CMS detector was developed and has been consistently used in physics analyses for the first time at a hadron collider as mentioned in this paper.
Abstract: The CMS apparatus was identified, a few years before the start of the LHC operation at CERN, to feature properties well suited to particle-flow (PF) reconstruction: a highly-segmented tracker, a fine-grained electromagnetic calorimeter, a hermetic hadron calorimeter, a strong magnetic field, and an excellent muon spectrometer. A fully-fledged PF reconstruction algorithm tuned to the CMS detector was therefore developed and has been consistently used in physics analyses for the first time at a hadron collider. For each collision, the comprehensive list of final-state particles identified and reconstructed by the algorithm provides a global event description that leads to unprecedented CMS performance for jet and hadronic τ decay reconstruction, missing transverse momentum determination, and electron and muon identification. This approach also allows particles from pileup interactions to be identified and enables efficient pileup mitigation methods. The data collected by CMS at a centre-of-mass energy of 8\TeV show excellent agreement with the simulation and confirm the superior PF performance at least up to an average of 20 pileup interactions.

719 citations


Journal ArticleDOI
TL;DR: The stimulated Raman adiabatic passage (STIRAP) was introduced by Gaubatz et al. as discussed by the authors, which allows efficient and selective population transfer between quantum states without suffering loss due to spontaneous emission.
Abstract: The technique of stimulated Raman adiabatic passage (STIRAP), which allows efficient and selective population transfer between quantum states without suffering loss due to spontaneous emission, was introduced in 1990 (Gaubatz \emph{et al.}, J. Chem. Phys. \textbf{92}, 5363, 1990). Since then STIRAP has emerged as an enabling methodology with widespread successful applications in many fields of physics, chemistry and beyond. This article reviews the many applications of STIRAP emphasizing the developments since 2000, the time when the last major review on the topic was written (Vitanov \emph{et al.}, Adv. At. Mol. Opt. Phys. \textbf{46}, 55, 2001). A brief introduction into the theory of STIRAP and the early applications for population transfer within three-level systems is followed by the discussion of several extensions to multi-level systems, including multistate chains and tripod systems. The main emphasis is on the wide range of applications in atomic and molecular physics (including atom optics, cavity quantum electrodynamics, formation of ultracold molecules, precision experiments, etc.), quantum information (including single- and two-qubit gates, entangled-state preparation, etc.), solid-state physics (including processes in doped crystals, nitrogen-vacancy centers, superconducting circuits, etc.), and even some applications in classical physics (including waveguide optics, frequency conversion, polarization optics, etc.). Promising new prospects for STIRAP are also presented (including processes in optomechanics, detection of parity violation in molecules, spectroscopy of core-nonpenetrating Rydberg states, and population transfer with X-ray pulses).

654 citations


Journal ArticleDOI
TL;DR: The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye disease (DED), biophysical and biochemical aspects of tears and how these change in DED and recommended areas for future research.
Abstract: The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears and how these change in DED. Clinically, DED is characterized by loss of tear volume, more rapid breakup of the tear film and increased evaporation of tears from the ocular surface. The tear film is composed of many substances including lipids, proteins, mucins and electrolytes. All of these contribute to the integrity of the tear film but exactly how they interact is still an area of active research. Tear film osmolarity increases in DED. Changes to other components such as proteins and mucins can be used as biomarkers for DED. The Subcommittee recommended areas for future research to advance our understanding of the tear film and how this changes with DED. The final report was written after review by all Subcommittee members and the entire TFOS DEWS II membership.

582 citations


Journal ArticleDOI
TL;DR: In this paper, the trigger system consists of two levels designed to select events of potential physics interest from a GHz (MHz) interaction rate of proton-proton (heavy ion) collisions.
Abstract: This paper describes the CMS trigger system and its performance during Run 1 of the LHC. The trigger system consists of two levels designed to select events of potential physics interest from a GHz (MHz) interaction rate of proton-proton (heavy ion) collisions. The first level of the trigger is implemented in hardware, and selects events containing detector signals consistent with an electron, photon, muon, tau lepton, jet, or missing transverse energy. A programmable menu of up to 128 object-based algorithms is used to select events for subsequent processing. The trigger thresholds are adjusted to the LHC instantaneous luminosity during data taking in order to restrict the output rate to 100 kHz, the upper limit imposed by the CMS readout electronics. The second level, implemented in software, further refines the purity of the output stream, selecting an average rate of 400 Hz for offline event storage. The objectives, strategy and performance of the trigger system during the LHC Run 1 are described.

532 citations


Journal ArticleDOI
Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam  +2285 moreInstitutions (147)
TL;DR: In this paper, an improved jet energy scale corrections, based on a data sample corresponding to an integrated luminosity of 19.7 fb^(-1) collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 8 TeV, are presented.
Abstract: Improved jet energy scale corrections, based on a data sample corresponding to an integrated luminosity of 19.7 fb^(-1) collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 8 TeV, are presented. The corrections as a function of pseudorapidity η and transverse momentum p_T are extracted from data and simulated events combining several channels and methods. They account successively for the effects of pileup, uniformity of the detector response, and residual data-simulation jet energy scale differences. Further corrections, depending on the jet flavor and distance parameter (jet size) R, are also presented. The jet energy resolution is measured in data and simulated events and is studied as a function of pileup, jet size, and jet flavor. Typical jet energy resolutions at the central rapidities are 15–20% at 30 GeV, about 10% at 100 GeV, and 5% at 1 TeV. The studies exploit events with dijet topology, as well as photon+jet, Z+jet and multijet events. Several new techniques are used to account for the various sources of jet energy scale corrections, and a full set of uncertainties, and their correlations, are provided. The final uncertainties on the jet energy scale are below 3% across the phase space considered by most analyses (p_T > 30 GeV and 0|η| 30 GeV is reached, when excluding the jet flavor uncertainties, which are provided separately for different jet flavors. A new benchmark for jet energy scale determination at hadron colliders is achieved with 0.32% uncertainty for jets with p_T of the order of 165–330 GeV, and |η| < 0.8.

505 citations


Journal ArticleDOI
TL;DR: Questions about instruments, methods and applications based on chlorophyll a fluorescence, and the answers draw on knowledge from different Chl a Fluorescence analysis domains, yielding in several cases new insights.
Abstract: Using chlorophyll (Chl) a fluorescence many aspects of the photosynthetic apparatus can be studied, both in vitro and, noninvasively, in vivo. Complementary techniques can help to interpret changes in the Chl a fluorescence kinetics. Kalaji et al. (Photosynth Res 122:121–158, 2014a) addressed several questions about instruments, methods and applications based on Chl a fluorescence. Here, additional Chl a fluorescence-related topics are discussed again in a question and answer format. Examples are the effect of connectivity on photochemical quenching, the correction of F V /F M values for PSI fluorescence, the energy partitioning concept, the interpretation of the complementary area, probing the donor side of PSII, the assignment of bands of 77 K fluorescence emission spectra to fluorescence emitters, the relationship between prompt and delayed fluorescence, potential problems when sampling tree canopies, the use of fluorescence parameters in QTL studies, the use of Chl a fluorescence in biosensor applications and the application of neural network approaches for the analysis of fluorescence measurements. The answers draw on knowledge from different Chl a fluorescence analysis domains, yielding in several cases new insights.

384 citations


Journal ArticleDOI
Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam  +2333 moreInstitutions (195)
TL;DR: In this paper, the authors acknowledge the enduring support for the construction and operation of the LHC and the CMS detector provided by the following funding agencies:======BMWFW and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,======And FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS======(Colombia); MSES and CSF (Croatia); RPF (
Abstract: we acknowledge the enduring support for the construction and operation of the LHC and the CMS detector provided by the following funding agencies: BMWFW and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES and CSF (Croatia); RPF (Cyprus); SENESCYT (Ecuador); MoER, ERC IUT and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); MSIP and NRF (Republic of Korea); LAS (Lithuania); MOE and UM (Malaysia); BUAP, CINVESTAV, CONACYT, LNS, SEP, and UASLP-FAI (Mexico); MBIE (New Zealand); PAEC (Pakistan); MSHE and NSC (Poland); FCT (Portugal); JINR (Dubna); MON, RosAtom, RAS and RFBR (Russia); MESTD (Serbia); SEIDI and CPAN (Spain); Swiss Funding Agencies (Switzerland); MST (Taipei); ThEPCenter, IPST, STAR and NSTDA (Thailand); TUBITAK and TAEK (Turkey); NASU and SFFR (Ukraine); STFC (United Kingdom); DOE and NSF (U.S.A.).

292 citations


Journal ArticleDOI
Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1, Federico Ambrogi1  +2294 moreInstitutions (194)
TL;DR: In this paper, the Higgs boson mass was measured in the H → ZZ → 4l (l = e, μ) decay channel and the signal strength modifiers for individual Higgs production modes were also measured.
Abstract: Properties of the Higgs boson are measured in the H → ZZ → 4l (l = e, μ) decay channel. A data sample of proton-proton collisions at $ \sqrt{s}=13 $ TeV, collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 35.9 fb$^{−1}$ is used. The signal strength modifier μ, defined as the ratio of the observed Higgs boson rate in the H → ZZ → 4l decay channel to the standard model expectation, is measured to be μ = 1.05$_{− 0.17}^{+ 0.19}$ at m$_{H}$ = 125.09 GeV, the combined ATLAS and CMS measurement of the Higgs boson mass. The signal strength modifiers for the individual Higgs boson production modes are also measured. The cross section in the fiducial phase space defined by the requirements on lepton kinematics and event topology is measured to be 2. 92$_{− 0.44}^{+ 0.48}$ (stat)$_{− 0.24}^{+ 0.28}$ (syst)fb, which is compatible with the standard model prediction of 2.76 ± 0.14 fb. Differential cross sections are reported as a function of the transverse momentum of the Higgs boson, the number of associated jets, and the transverse momentum of the leading associated jet. The Higgs boson mass is measured to be m$_{H}$ = 125.26 ± 0.21 GeV and the width is constrained using the on-shell invariant mass distribution to be Γ$_{H}$ < 1.10 GeV, at 95% confidence level.

290 citations


Journal ArticleDOI
TL;DR: In this article, the second-order and third-order azimuthal anisotropy harmonics of unidentified charged particles, as well as v2v2 of View the MathML sourceKS0 and ViewTheMathML sourceΛ/Λ ǫ particles, are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum.

288 citations


Journal ArticleDOI
Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam  +2325 moreInstitutions (191)
TL;DR: In this paper, an upper bound on the branching fraction of the Higgs boson decay to invisible particles, as a function of the assumed production cross-sections, was established, and the results were also interpreted in the context of Higgs-portal dark matter models.
Abstract: Searches for invisible decays of the Higgs boson are presented. The data collected with the CMS detector at the LHC correspond to integrated luminosities of 5.1, 19.7, and 2.3 fb−1 at centre-of-mass energies of 7, 8, and 13 TeV, respectively. The search channels target Higgs boson production via gluon fusion, vector boson fusion, and in association with a vector boson. Upper limits are placed on the branching fraction of the Higgs boson decay to invisible particles, as a function of the assumed production cross sections. The combination of all channels, assuming standard model production, yields an observed (expected) upper limit on the invisible branching fraction of 0.24 (0.23) at the 95% confidence level. The results are also interpreted in the context of Higgs-portal dark matter models.

208 citations


Journal ArticleDOI
E. Cortina Gil1, E. Martin Albarran1, E. Minucci1, G. Nüssle1  +291 moreInstitutions (17)
TL;DR: NA62 as mentioned in this paper is a fixed-target experiment at the CERN SPS dedicated to measurements of rare kaon decays, such as the branching fraction of the K+ → π+ ν bar nu decay, which can bring significant insights into new physics processes when comparison is made with precise theoretical predictions.
Abstract: NA62 is a fixed-target experiment at the CERN SPS dedicated to measurements of rare kaon decays. Such measurements, like the branching fraction of the K+ → π+ ν bar nu decay, have the potential to bring significant insights into new physics processes when comparison is made with precise theoretical predictions. For this purpose, innovative techniques have been developed, in particular, in the domain of low-mass tracking devices. Detector construction spanned several years from 2009 to 2014. The collaboration started detector commissioning in 2014 and will collect data until the end of 2018. The beam line and detector components are described together with their early performance obtained from 2014 and 2015 data.

Journal ArticleDOI
TL;DR: A meta-analysis of all studies assessing risk of prevalence and incidence of diabetes found a high risk of diabetes incidence for cadmium exposure, which was higher for studies using urine as exposure assessment.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Ece Aşılar  +2238 moreInstitutions (155)
TL;DR: In this article, the authors acknowledge the enduring support for the construction and operation of the LHC and the CMS detector provided by the following funding agencies: BMWFW and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MOST, and NSFC (China); COLCIEN-CIAS (Colombia); DAE and DST (India); IPM (Iran);

Journal ArticleDOI
Pedro W. Crous, Michael J. Wingfield1, Treena I. Burgess2, Angus J. Carnegie, G.E.St.J. Hardy2, David Smith, Brett A. Summerell3, J. F. Cano-Lira4, Josep Guarro4, Jos Houbraken, Lorenzo Lombard, María P. Martín5, Marcelo Sandoval-Denis, A. V. Alexandrova6, C. W. Barnes, Iuri Goulart Baseia7, Jadson D. P. Bezerra8, Vladimiro Guarnaccia, Tom W. May3, Margarita Hernández-Restrepo, Alberto M. Stchigel4, Andrew N. Miller9, M.E. Ordoñez10, V.P. Abreu11, Thiago Accioly7, C. Agnello, A. Agustin Colmán11, Cynthia Cavalcanti de Albuquerque, Donis S. Alfredo7, Pablo Alvarado, Gianne R. Araújo-Magalhães12, S. Arauzo, T. Atkinson13, A. Barili10, Robert W. Barreto11, José Luiz Bezerra14, Tiara Sousa Cabral15, F. Camello Rodríguez, Rhudson Henrique Santos Ferreira da Cruz7, Pablo P. Daniëls16, B.D.B. da Silva17, Davi Augusto Carneiro de Almeida18, A.A. de Carvalho Júnior, Cony Decock19, Lynn Delgat20, S. Denman, Roumen Dimitrov21, Jacqueline Edwards22, A. G. Fedosova23, Renato Juciano Ferreira8, A. L. Firmino24, J.A. Flores10, Dania García4, Josepa Gené4, Alejandra Giraldo, J. S. Góis7, André A. M. Gomes11, Camila Melo Gonçalves8, D.E. Gouliamova25, Marizeth Groenewald, Borislav Guéorguiev26, Marcela Guevara-Suarez4, Luís Fernando Pascholati Gusmão18, Kentaro Hosaka, Vit Hubka27, Sabine M. Huhndorf, M. Jadan, Željko Jurjević, Bart Kraak, Viktor Kučera28, T.K.A. Kumar, I. Kusan, Sírleis Rodrigues Lacerda, S. Lamlertthon29, W. S. Lisboa11, Michael Loizides, J. Jennifer Luangsa-ard30, Pavlina Lyskova, W.P. Mac Cormack31, D. M. Macedo, A. R. Machado8, E. F. Malysheva23, Paulo Marinho7, Neven Matočec, M. Meijer, Armin Mešić, Suchada Mongkolsamrit30, Keila Aparecida Moreira12, O. V. Morozova23, K.U. Nair32, N. Nakamura33, W. Noisripoom30, Ibai Olariaga, Rafael J. V. De Oliveira8, Laura M. Paiva8, P. Pawar32, Olinto Liparini Pereira11, Stephen W. Peterson34, María Prieto35, E. Rodríguez-Andrade4, C. Rojo De Blas, Mélanie Roy, Everaldo Silvino dos Santos7, Rohit Sharma32, Gladstone Alves da Silva8, Cristina Maria de Souza-Motta8, Y. Takeuchi-Kaneko33, C. Tanaka33, Awalendra K. Thakur32, M.Th. Smith, Zdenko Tkalčec, N. Valenzuela-Lopez4, P. van der Kleij36, Annemieke Verbeken20, Marcelino Gevilbergue Viana7, X.W. Wang37, Johannes Z. Groenewald 
TL;DR: Novel species of fungi described in this study include those from various countries as follows: Antarctica: Cadophora antarctica from soil.
Abstract: Novel species of fungi described in this study include those from various countries as follows: Antarctica: Cadophora antarctica from soil. Australia: Alfaria dandenongensis on Cyperaceae, Amphosoma persooniae on Persoonia sp., Anungitea nullicana on Eucalyptus sp., Bagadiella eucalypti on Eucalyptus globulus, Castanediella eucalyptigena on Eucalyptus sp., Cercospora dianellicola on Dianella sp., Cladoriella kinglakensis on Eucalyptus regnans, Cladoriella xanthorrhoeae (incl. Cladoriellaceae fam. nov. and Cladoriellales ord. nov.) on Xanthorrhoea sp., Cochlearomyces eucalypti (incl. Cochlearomyces gen. nov. and Cochlearomycetaceae fam. nov.) on Eucalyptus obliqua, Codinaea lambertiae on Lambertia formosa, Diaporthe obtusifoliae on Acacia obtusifolia, Didymella acaciae on Acacia melanoxylon, Dothidea eucalypti on Eucalyptus dalrympleana, Fitzroyomyces cyperi (incl. Fitzroyomyces gen. nov.) on Cyperaceae, Murramarangomyces corymbiae (incl. Murramarangomyces gen. nov., Murramarangomycetaceae fam. nov. and Murramarangomycetales ord. nov.) on Corymbia maculata, Neoanungitea eucalypti (incl. Neoanungitea gen. nov.) on Eucalyptus obliqua, Neoconiothyrium persooniae (incl. Neoconiothyrium gen. nov.) on Persoonia laurina subsp. laurina, Neocrinula lambertiae (incl. Neocrinulaceae fam. nov.) on Lambertia sp., Ochroconis podocarpi on Podocarpus grayae, Paraphysalospora eucalypti (incl. Paraphysalospora gen. nov.) on Eucalyptus sieberi, Pararamichloridium livistonae (incl. Pararamichloridium gen. nov., Pararamichloridiaceae fam. nov. and Pararamichloridiales ord. nov.) on Livistona sp., Pestalotiopsis dianellae on Dianella sp., Phaeosphaeria gahniae on Gahnia aspera, Phlogicylindrium tereticornis on Eucalyptus tereticornis, Pleopassalora acaciae on Acacia obliquinervia, Pseudodactylaria xanthorrhoeae (incl. Pseudodactylaria gen. nov., Pseudodactylariaceae fam. nov. and Pseudodactylariales ord. nov.) on Xanthorrhoea sp., Pseudosporidesmium lambertiae (incl. Pseudosporidesmiaceae fam. nov.) on Lambertia formosa, Saccharata acaciae on Acacia sp., Saccharata epacridis on Epacris sp., Saccharata hakeigena on Hakea sericea, Seiridium persooniae on Persoonia sp., Semifissispora tooloomensis on Eucalyptus dunnii, Stagonospora lomandrae on Lomandra longifolia, Stagonospora victoriana on Poaceae, Subramaniomyces podocarpi on Podocarpus elatus, Sympoventuria melaleucae on Melaleuca sp., Sympoventuria regnans on Eucalyptus regnans, Trichomerium eucalypti on Eucalyptus tereticornis, Vermiculariopsiella eucalypticola on Eucalyptus dalrympleana, Verrucoconiothyrium acaciae on Acacia falciformis, Xenopassalora petrophiles (incl. Xenopassalora gen. nov.) on Petrophile sp., Zasmidium dasypogonis on Dasypogon sp., Zasmidium gahniicola on Gahnia sieberiana. Brazil: Achaetomium lippiae on Lippia gracilis, Cyathus isometricus on decaying wood, Geastrum caririense on soil, Lycoperdon demoulinii (incl. Lycoperdon subg. Arenicola) on soil, Megatomentella cristata (incl. Megatomentella gen. nov.) on unidentified plant, Mutinus verrucosus on soil, Paraopeba schefflerae (incl. Paraopeba gen. nov.) on Schefflera morototoni, Phyllosticta catimbauensis on Mandevilla catimbauensis, Pseudocercospora angularis on Prunus persica, Pseudophialophora sorghi on Sorghum bicolor, Spumula piptadeniae on Piptadenia paniculata. Bulgaria: Yarrowia parophonii from gut of Parophonus hirsutulus. Croatia: Pyrenopeziza velebitica on Lonicera borbasiana. Cyprus: Peziza halophila on coastal dunes. Czech Republic: Aspergillus contaminans from human fingernail. Ecuador: Cuphophyllus yacurensis on forest soil, Ganoderma podocarpense on fallen tree trunk. England: Pilidium anglicum (incl. Chaetomellales ord. nov.) on Eucalyptus sp. France: Planamyces parisiensis (incl. Planamyces gen. nov.) on wood inside a house. French Guiana: Lactifluus ceraceus on soil. Germany: Talaromyces musae on Musa sp. India: Hyalocladosporiella cannae on Canna indica, Nothophoma raii from soil. Italy: Setophaeosphaeria citri on Citrus reticulata, Yuccamyces citri on Citrus limon. Japan: Glutinomyces brunneus (incl. Glutinomyces gen. nov.) from roots of Quercus sp. Netherlands (all from soil): Collariella hilkhuijsenii, Fusarium petersiae, Gamsia kooimaniorum, Paracremonium binnewijzendii, Phaeoisaria annesophieae, Plectosphaerella niemeijerarum, Striaticonidium deklijnearum, Talaromyces annesophieae, Umbelopsis wiegerinckiae, Vandijckella johannae (incl. Vandijckella gen. nov. and Vandijckellaceae fam. nov.), Verhulstia trisororum (incl. Verhulstia gen. nov.). New Zealand: Lasiosphaeria similisorbina on decorticated wood. Papua New Guinea: Pseudosubramaniomyces gen. nov. (based on Pseudosubramaniomyces fusisaprophyticus comb. nov.). Slovakia: Hemileucoglossum pusillum on soil. South Africa: Tygervalleyomyces podocarpi (incl. Tygervalleyomyces gen. nov.) on Podocarpus falcatus. Spain: Coniella heterospora from herbivorous dung, Hymenochaete macrochloae on Macrochloa tenacissima, Ramaria cistophila on shrubland of Cistus ladanifer. Thailand: Polycephalomyces phaothaiensis on Coleoptera larvae, buried in soil. Uruguay: Penicillium uruguayense from soil. Vietnam: Entoloma nigrovelutinum on forest soil, Volvariella morozovae on wood of unknown tree. Morphological and culture characteristics along with DNA barcodes are provided.

Journal ArticleDOI
TL;DR: The characteristics of coal-derived UCs are a function of the rank and type of the coal, as well as the size of the feed coal and the combustion conditions as discussed by the authors, and the nature of UCs resulting from vitrinite is dependent upon the coal rank.

Journal ArticleDOI
TL;DR: Plasma RAS determination showed high overall agreement and captured a mCRC population responsive to anti-EGFR therapy with the same predictive level as SoC tissue testing, and the feasibility and practicality of ctDNA analysis may translate into an alternative tool for anti- EGFR treatment selection.

Posted ContentDOI
Iain Mathieson1, Songül Alpaslan-Roodenberg1, Cosimo Posth2, Anna Szécsényi-Nagy3, Nadin Rohland1, Swapan Mallick1, Iñigo Olalde1, Nasreen Broomandkhoshbacht1, Olivia Cheronet4, Daniel Fernandes4, Matthew Ferry1, Beatriz Gamarra4, Gloria G. Fortes5, Wolfgang Haak2, Eadaoin Harney1, Ben Krause-Kyora2, Isil Kucukkalipci6, Megan Michel1, Alissa Mittnik6, Kathrin Nägele2, Mario Novak4, Jonas Oppenheimer1, Nick Patterson7, Saskia Pfrengle6, Kendra Sirak8, Kristin Stewardson1, Stefania Vai9, Stefan Alexandrov10, Kurt W. Alt11, Radian Andreescu, Dragana Antonović, Abigail Ash4, Nadezhda Atanassova10, Krum Bacvarov10, Mende Balázs Gusztáv3, Hervé Bocherens6, Michael Bolus6, Adina Boroneanţ12, Yavor Boyadzhiev10, Alicja Budnik, Josip Burmaz, Stefan Chohadzhiev, Nicholas J. Conard6, Richard Cottiaux, Maja Čuka, Christophe Cupillard13, Dorothée G. Drucker6, Nedko Elenski, Michael Francken6, Borislava Galabova, Georgi Ganetsovski, Bernard Gély, Tamás Hajdu14, Veneta Handzhyiska15, Katerina Harvati6, Thomas Higham16, Stanislav Iliev, Ivor Janković17, Ivor Karavanić17, Douglas J. Kennett18, Darko Komšo, Alexandra Kozak19, Damian Labuda20, Martina Lari9, Cătălin Lazăr21, Maleen Leppek22, Krassimir Leshtakov15, Domenico Lo Vetro9, Dženi Los, Ivaylo Lozanov15, Maria Malina6, Fabio Martini9, Kath McSweeney23, Harald Meller, Marko Menđušić, Pavel Mirea, Vyacheslav Moiseyev, Vanya Petrova15, T. Douglas Price24, Angela Simalcsik12, Luca Sineo25, Mario Šlaus26, Vladimir Slavchev, Petar Stanev, Andrej Starović, Tamás Szeniczey14, Sahra Talamo2, Maria Teschler-Nicola27, Corinne Thevenet, Ivan Valchev15, Frédérique Valentin13, Sergey Vasilyev28, Fanica Veljanovska, Svetlana Venelinova, Elizaveta Veselovskaya28, Bence Viola29, Cristian Virag, Joško Zaninović, Steve Zäuner, Philipp W. Stockhammer22, Giulio Catalano25, Raiko Krauß6, David Caramelli9, Gunita Zariņa30, Bisserka Gaydarska31, Malcolm Lillie32, Alexey G. Nikitin33, Inna Potekhina19, Anastasia Papathanasiou, Dusan Boric34, Clive Bonsall23, Johannes Krause2, Ron Pinhasi35, David Reich1 
09 May 2017-bioRxiv
TL;DR: It is shown that southeastern Europe continued to be a nexus between East and West, with intermittent steppe ancestry, including in individuals from the Varna I cemetery and associated with the Cucuteni-Trypillian archaeological complex, up to 2,000 years before the Steppe migration that replaced much of northern Europe’s population.
Abstract: Farming was first introduced to southeastern Europe in the mid-7th millennium BCE - brought by migrants from Anatolia who settled in the region before spreading throughout Europe. However, the dynamics of the interaction between the first farmers and the indigenous hunter-gatherers remain poorly understood because of the near absence of ancient DNA from the region. We report new genome-wide ancient DNA data from 204 individuals-65 Paleolithic and Mesolithic, 93 Neolithic, and 46 Copper, Bronze and Iron Age-who lived in southeastern Europe and surrounding regions between about 12,000 and 500 BCE. We document that the hunter-gatherer populations of southeastern Europe, the Baltic, and the North Pontic Steppe were distinctive from those of western Europe, with a West-East cline of ancestry. We show that the people who brought farming to Europe were not part of a single population, as early farmers from southern Greece are not descended from the Neolithic population of northwestern Anatolia that was ancestral to all other European farmers. The ancestors of the first farmers of northern and western Europe passed through southeastern Europe with limited admixture with local hunter-gatherers, but we show that some groups that remained in the region mixed extensively with local hunter-gatherers, with relatively sex-balanced admixture compared to the male-biased hunter-gatherer admixture that we show prevailed later in the North and West. After the spread of farming, southeastern Europe continued to be a nexus between East and West, with intermittent steppe ancestry, including in individuals from the Varna I cemetery and associated with the Cucuteni-Trypillian archaeological complex, up to 2,000 years before the Steppe migration that replaced much of northern Europe9s population.

Journal ArticleDOI
TL;DR: The observed differences between the same and opposite sign correlations, as functions of multiplicity and η gap between the two charged particles, are of similar magnitude in p-Pb and PbPb collisions at the same multiplicities.
Abstract: Charge-dependent azimuthal particle correlations with respect to the second-order event plane in pPb and PbPb collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV have been studied with the CMS experiment at the LHC. The measurement is performed with a three-particle correlation technique, using two particles with the same or opposite charge within the pseudorapidity range abs(eta)<2.4, and a third particle measured in the hadron forward calorimeters (4.4< abs(eta)<5). The observed differences between the same and opposite sign correlations, as functions of multiplicity and eta gap between the two charged particles, are of similar magnitude in pPb and PbPb collisions at the same multiplicities. These results pose a challenge for the interpretation of charge-dependent azimuthal correlations in heavy ion collisions in terms of the chiral magnetic effect.

Journal ArticleDOI
C. M. Raiteri1, M. Villata1, J. A. Acosta-Pulido2, J. A. Acosta-Pulido3, Ivan Agudo2, Arkady A. Arkharov4, Rumen Bachev5, G. V. Baida, Erika Benítez6, G. A. Borman, W. Boschin1, W. Boschin2, W. Boschin3, V. Bozhilov7, M. S. Butuzova, P. Calcidese, M. I. Carnerero1, D. Carosati1, Carolina Casadio8, Carolina Casadio2, N. Castro-Segura9, N. Castro-Segura3, Wen Ping Chen10, Goran Damljanović, Filippo D'Ammando11, Filippo D'Ammando1, A. Di Paola1, J. Echevarría6, N. V. Efimova4, Sh. A. Ehgamberdiev, C. Espinosa6, Antonio Fuentes2, A. Giunta1, José L. Gómez2, T. S. Grishina12, Mark Gurwell13, David Hiriart6, Helen Jermak14, B. Jordan15, Svetlana G. Jorstad16, Svetlana G. Jorstad12, Manasvita Joshi16, E. N. Kopatskaya12, K. Kuratov17, K. Kuratov18, Omar M. Kurtanidze, Sofia O. Kurtanidze, Anne Lähteenmäki19, Anne Lähteenmäki20, Valeri M. Larionov12, Valeri M. Larionov4, Elena G. Larionova12, L. V. Larionova12, C. Lázaro3, C. Lázaro2, C. S. Lin10, Michael P. Malmrose16, Alan P. Marscher16, Katsura Matsumoto21, B. McBreen22, Raul Michel6, Boyko Mihov5, M. Minev7, D. O. Mirzaqulov, A. A. Mokrushina4, A. A. Mokrushina12, Sol N. Molina2, Joseph Moody23, D. A. Morozova12, S. V. Nazarov, M. G. Nikolashvili, J. M. Ohlert24, D. N. Okhmat, Evgeni Ovcharov7, F. Pinna2, F. Pinna3, T. A. Polakis, C. Protasio2, C. Protasio3, T. Pursimo, F. J. Redondo-Lorenzo2, F. J. Redondo-Lorenzo3, N. Rizzi, G. Rodriguez-Coira3, G. Rodriguez-Coira2, Kozo Sadakane21, A. C. Sadun25, Manash R. Samal10, Sergey S. Savchenko12, Evgeni Semkov5, Brian Skiff26, L. Slavcheva-Mihova5, Paul S. Smith27, Iain A. Steele14, A. Strigachev5, Joni Tammi20, Clemens Thum, Merja Tornikoski20, Yu. V. Troitskaya12, Ivan S. Troitsky12, A. A. Vasilyev12, O. Vince 
04 Dec 2017-Nature
TL;DR: It is shown that the observed long-term trends of the flux and spectral variability are best explained by an inhomogeneous, curved jet that undergoes changes in orientation over time, and proposes that magnetohydrodynamic instabilities or rotation of the twisted jet cause different jet regions to change their orientation and hence their relative Doppler factors.
Abstract: Blazars are active galactic nuclei, which are powerful sources of radiation whose central engine is located in the core of the host galaxy. Blazar emission is dominated by non-thermal radiation from a jet that moves relativistically towards us, and therefore undergoes Doppler beaming. This beaming causes flux enhancement and contraction of the variability timescales, so that most blazars appear as luminous sources characterized by noticeable and fast changes in brightness at all frequencies. The mechanism that produces this unpredictable variability is under debate, but proposed mechanisms include injection, acceleration and cooling of particles, with possible intervention of shock waves or turbulence. Changes in the viewing angle of the observed emitting knots or jet regions have also been suggested as an explanation of flaring events and can also explain specific properties of blazar emission, such as intra-day variability, quasi-periodicity and the delay of radio flux variations relative to optical changes. Such a geometric interpretation, however, is not universally accepted because alternative explanations based on changes in physical conditions-such as the size and speed of the emitting zone, the magnetic field, the number of emitting particles and their energy distribution-can explain snapshots of the spectral behaviour of blazars in many cases. Here we report the results of optical-to-radio-wavelength monitoring of the blazar CTA 102 and show that the observed long-term trends of the flux and spectral variability are best explained by an inhomogeneous, curved jet that undergoes changes in orientation over time. We propose that magnetohydrodynamic instabilities or rotation of the twisted jet cause different jet regions to change their orientation and hence their relative Doppler factors. In particular, the extreme optical outburst of 2016-2017 (brightness increase of six magnitudes) occurred when the corresponding emitting region had a small viewing angle. The agreement between observations and theoretical predictions can be seen as further validation of the relativistic beaming theory.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Ece Aşılar  +2300 moreInstitutions (195)
TL;DR: In this paper, a search for dark matter particles is performed using events with large missing transverse momentum, at least one energetic jet, and no leptons, in proton-proton collisions at root S = 13TeV collected with the CMS detector at the LHC.
Abstract: A search for dark matter particles is performed using events with large missing transverse momentum, at least one energetic jet, and no leptons, in proton-proton collisions at root S = 13TeV collected with the CMS detector at the LHC. The data sample corresponds to an integrated luminosity of 12.9 fb(-1). The search includes events with jets from the hadronic decays of a W or Z boson. The data are found to be in agreement with the predicted background contributions from standard model processes. The results are presented in terms of simpli fi ed models in which dark matter particles are produced through interactions involving a vector, axial-vector, scalar, or pseudoscalar mediator. Vector and axial-vector mediator particles with masses up to 1.95TeV, and scalar and pseudoscalar mediator particles with masses up to 100 and 430 GeV respectively, are excluded at 95% con fi dence level. The results are also interpreted in terms of the invisible decays of the Higgs boson, yielding an observed (expected) 95% con fi dence level upper limit of 0.44 (0.56) on the corresponding branching fraction. The results of this search provide the strongest constraints on the dark matter pair production cross section through vector and axial-vector mediators at a particle collider. When compared to the direct detection experiments, the limits obtained from this search provide stronger constraints for dark matter masses less than 5, 9, and 550 GeV, assuming vector, scalar, and axial-vector mediators, respectively. The search yields stronger constraints for dark matter masses less than 200 GeV, assuming a pseudoscalar mediator, when compared to the indirect detection results from Fermi-LAT.

Journal ArticleDOI
TL;DR: In this article, the authors review the most recent progress in engineering high performance conducting polymer-based supercapacitor electrodes, emphasizing the successful techniques for polymer synthesis, nanostructuring, and compositing with carbon or metal oxides which have been used to optimize each of the most important supercapACitor performance metrics.
Abstract: Supercapacitors based on conducting polymers promise to bridge the gap between the high power densities of carbon-based double-layer capacitors and the high energy densities of batteries. While much work has focused on improving the specific capacitance of these materials, emerging applications also demand competitive performance with regards to a variety of other criteria, including long-term cycling stability, mechanical robustness, and scalability of fabrication. There is no consolidated summary in the literature, however, of the specific strategies used to target these individual metrics as well as the tradeoffs that exist between them. Herein, we review the most recent progress in engineering high performance conducting polymer-based supercapacitor electrodes, emphasizing the successful techniques for polymer synthesis, nanostructuring, and compositing with carbon or metal oxides which have been used to optimize each of the most important supercapacitor performance metrics.

Journal ArticleDOI
TL;DR: In this article, the authors acknowledge the enduring support for the construction and operation of the LHC and the CMS detector provided by the following funding agencies: BMWFW and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MOST, and NSFC (China); COLCIEN-CIAS (Colombia); DAE and DST (India); IPM (Iran); S

Journal ArticleDOI
TL;DR: The one-pot synthesis of silanol-free nanosized MFI-type zeolites is reported and characterized by introducing atomically dispersed tungsten; this prevents silanol group occurrence by forming flexible W-O-Si bridges.
Abstract: Nanostructured zeolites were synthesized without hydrophilic silanol groups, and without fluoridation, via the introduction of atomically dispersed tungsten. This resulted in improved catalytic and gas separation properties.

Journal ArticleDOI
TL;DR: It is demonstrated that surface roughness strongly pins the particles' contact lines and arrests their adsorption in long-lived metastable positions, and the roughness-induced interface deformations around isolated particles are measured to indicate future design rules for particle-based emulsifiers.
Abstract: Surface heterogeneities, including roughness, significantly affect the adsorption, motion and interactions of particles at fluid interfaces. However, a systematic experimental study, linking surface roughness to particle wettability at a microscopic level, is currently missing. Here we synthesize a library of all-silica microparticles with uniform surface chemistry, but tuneable surface roughness and study their spontaneous adsorption at oil-water interfaces. We demonstrate that surface roughness strongly pins the particles' contact lines and arrests their adsorption in long-lived metastable positions, and we directly measure the roughness-induced interface deformations around isolated particles. Pinning imparts tremendous contact angle hysteresis, which can practically invert the particle wettability for sufficient roughness, irrespective of their chemical nature. As a unique consequence, the same rough particles stabilize both water-in-oil and oil-in-water emulsions depending on the phase they are initially dispersed in. These results both shed light on fundamental phenomena concerning particle adsorption at fluid interfaces and indicate future design rules for particle-based emulsifiers.

Journal ArticleDOI
Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam  +2264 moreInstitutions (154)
TL;DR: In this paper, a search for narrow resonances in dielectron and dimuon invariant mass spectra has been performed using data obtained from proton-proton collisions at $\sqrt{s}=13$ TeV collected with the CMS detector.

Journal ArticleDOI
TL;DR: Severe infection constitutes a predictor of poor prognosis in SLE patients, is more common in Latin-Americans and is associated with age, previous infection, and smoking, and antimalarials exerted a protective effect.

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Federico Ambrogi  +2205 moreInstitutions (150)
TL;DR: In this article, a search for new phenomena is performed using events with jets and significant transverse momentum imbalance, as inferred through the $M_{\mathrm {T2}}$ variable.
Abstract: A search for new phenomena is performed using events with jets and significant transverse momentum imbalance, as inferred through the $M_{\mathrm {T2}}$ variable The results are based on a sample of proton–proton collisions collected in 2016 at a center-of-mass energy of 13 $\,\text {TeV}$ with the CMS detector and corresponding to an integrated luminosity of 359 $\,\text {fb}^\text {-1}$ No excess event yield is observed above the predicted standard model background, and the results are interpreted as exclusion limits at 95% confidence level on the masses of predicted particles in a variety of simplified models of R-parity conserving supersymmetry Depending on the details of the model, 95% confidence level lower limits on the gluino (light-flavor squark) masses are placed up to 2025 (1550) $\,\text {GeV}$ Mass limits as high as 1070 (1175) $\,\text {GeV}$ are set on the masses of top (bottom) squarks Information is provided to enable re-interpretation of these results, including model-independent limits on the number of non-standard model events for a set of simplified, inclusive search regions

Journal ArticleDOI
TL;DR: An attempt is made to outline the future hot directions of research into the field ranging from quest for molecules that can significantly alter TFLL properties to addressing open questions on the contribution of TFLL to the overall performance of the TF.

Journal ArticleDOI
TL;DR: In each FBUP, eye dryness and fatigue were the severest symptoms, and the 5 different FBUPs constituted different groups, reflecting different pathophysi-ologies.

Proceedings ArticleDOI
01 Jan 2017
TL;DR: The authors proposed a general-purpose framework for fully-automatic fact checking using external sources, tapping the potential of the entire Web as a knowledge source to confirm or reject a claim, using a deep neural network with LSTM text encoding to combine semantic kernels with task-specific embeddings.
Abstract: Given the constantly growing proliferation of false claims online in recent years, there has been also a growing research interest in automatically distinguishing false rumors from factually true claims. Here, we propose a general-purpose framework for fully-automatic fact checking using external sources, tapping the potential of the entire Web as a knowledge source to confirm or reject a claim. Our framework uses a deep neural network with LSTM text encoding to combine semantic kernels with task-specific embeddings that encode a claim together with pieces of potentially relevant text fragments from the Web, taking the source reliability into account. The evaluation results show good performance on two different tasks and datasets: (i) rumor detection and (ii) fact checking of the answers to a question in community question answering forums.