Technische Universität Darmstadt

About: Technische Universität Darmstadt is a education organization based out in Darmstadt, Germany. It is known for research contribution in the topics: Computer science & Context (language use). The organization has 17316 authors who have published 40619 publications receiving 937916 citations. The organization is also known as: Darmstadt University of Technology & University of Darmstadt.

Nonperturbative shell-model interactions from the in-medium similarity renormalization group.

Abstract: We present the first ab initio construction of valence-space Hamiltonians for medium-mass nuclei based on chiral two- and three-nucleon interactions using the in-medium similarity renormalization group. When applied to the oxygen isotopes, we find experimental ground-state energies are well reproduced, including the flat trend beyond the drip line at (24)O. Similarly, natural-parity spectra in (21,22,23,24)O are in agreement with experiment, and we present predictions for excited states in (25,26)O. The results exhibit a weak dependence on the harmonic-oscillator basis parameter and reproduce spectroscopy within the standard sd valence space.

Europium production: neutron star mergers versus core-collapse supernovae

Abstract: We have explored the Eu production in the Milky Way by means of a very detailed chemical evolution model. In particular, we have assumed that Eu is formed in merging neutron star (or neutron star black hole) binaries as well as in type II sup ernovae. We have tested the effects of several important parameters influencing the pro duction of Eu during the merging of two neutron stars, such as: i) the time scale of coalescenc e, ii) the Eu yields and iii) the range of initial masses for the progenitors of the neutron st ars. The yields of Eu from type II supernovae are very uncertain, more than those from coalescing neutron stars, so we have explored several possibilities. We have compared our model results with the observed rate of coalescence of neutron stars, the solar Eu abundance, the [Eu/Fe] versus [Fe/H] relation in the solar vicinity and the [Eu/H] gradient along the Galactic disc. Our main results can be summarized as follows: i) neutron star mergers can be entirely responsible for the production of Eu in the Galaxy if the coalescence time scale is no longer than 1 Myr for the bulk of binary systems, the Eu yield is around 3 × 10 −7 M⊙, and the mass range of progenitors of neutron stars is 9‐50 M⊙; ii) both type II supernovae and merging neutron stars can produce the right amount of Eu if the neutron star mergers produce 2 × 10 −7 M⊙ per system and type II supernovae, with progenitors in the range 20‐50 M⊙, produce yields of Eu of the order of 10 −8 ‐10 −9 M⊙; iii) either models with only neutron stars producing Eu or mixed ones can reproduce the observed Eu abundance gradient along the Galactic disc.

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair

Abstract: We have already reported that epidermal growth factor receptor/phosphatidylinositol 3-kinase/AKT signaling is an important pathway in regulating radiation sensitivity and DNA double-strand break (DNA-dsb) repair of human tumor cells. In the present study, we investigated the effect of AKT1 on DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity and DNA-dsb repair in irradiated non-small cell lung cancer cell lines A549 and H460. Treatment of cells with the specific AKT pathway inhibitor API-59 CJ-OH (API; 1-5 micromol/L) reduced clonogenic survival between 40% and 85% and enhanced radiation sensitivity of both cell lines significantly. As indicated by fluorescence-activated cell sorting analysis (sub-G(1) cells) and poly(ADP-ribose) polymerase cleavage, API treatment or transfection with AKT1-small interfering RNA (siRNA) induced apoptosis of H460 but not of A549 cells. However, in either apoptosis-resistant A549 or apoptosis-sensitive H460 cells, API and/or AKT1-siRNA did not enhance poly(ADP-ribose) polymerase cleavage and apoptosis following irradiation. Pretreatment of cells with API or transfection with AKT1-siRNA strongly inhibited radiation-induced phosphorylation of DNA-PKcs at T2609 and S2056 as well as repair of DNA-dsb as measured by the gamma-H2AX foci assay. Coimmunoprecipitation experiments showed a complex formation of activated AKT and DNA-PKcs, supporting the assumption that AKT plays an important regulatory role in the activation of DNA-PKcs in irradiated cells. Thus, targeting of AKT enhances radiation sensitivity of lung cancer cell lines A549 and H460 most likely through specific inhibition of DNA-PKcs-dependent DNA-dsb repair but not through enhancement of radiation-induced apoptosis.