Université libre de Bruxelles

About: Université libre de Bruxelles is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Breast cancer. The organization has 24974 authors who have published 56969 publications receiving 2084303 citations. The organization is also known as: ULB.

The value of blood lactate kinetics in critically ill patients: a systematic review

Abstract: The time course of blood lactate levels could be helpful to assess a patient’s response to therapy. Although the focus of published studies has been largely on septic patients, many other studies have reported serial blood lactate levels in different groups of acutely ill patients. We performed a systematic search of PubMed, Science Direct, and Embase until the end of February 2016 plus reference lists of relevant publications. We selected all observational and interventional studies that evaluated the capacity of serial blood lactate concentrations to predict outcome. There was no restriction based on language. We excluded studies in pediatric populations, experimental studies, and studies that did not report changes in lactate values or all-cause mortality rates. We separated studies according to the type of patients included. We collected data on the number of patients, timing of lactate measurements, minimum lactate level needed for inclusion if present, and suggested time interval for predictive use. A total of 96 studies met our criteria: 14 in general ICU populations, five in general surgical ICU populations, five in patients post cardiac surgery, 14 in trauma patients, 39 in patients with sepsis, four in patients with cardiogenic shock, eight in patients after cardiac arrest, three in patients with respiratory failure, and four in other conditions. A decrease in lactate levels over time was consistently associated with lower mortality rates in all subgroups of patients. Most studies reported changes over 6, 12 or 24 hrs, fewer used shorter time intervals. Lactate kinetics did not appear very different in patients with sepsis and other types of patients. A few studies suggested that therapy could be guided by these measurements. The observation of a better outcome associated with decreasing blood lactate concentrations was consistent throughout the clinical studies, and was not limited to septic patients. In all groups, the changes are relatively slow, so that lactate measurements every 1–2 hrs are probably sufficient in most acute conditions. The value of lactate kinetics appears to be valid regardless of the initial value.

A Gendered Assessment of Highly Skilled Emigration

Abstract: Although women form a large and increasing proportion of international migrants, women's mobility has generally been overlooked in the literature. Quantifying and characterizing female migration should lead to a better understanding of the forces that shape international migration. We build an original data set providing gender-disaggregated indicators of international migration by educational attainment for 195 source countries in 1990 and 2000. We find that women represent an increasing share of the immigration stock in the OECD countries and exhibit higher skilled emigration rates than men.

Training adaptations in the behavior of human motor units

Abstract: The purpose of this brief review is to examine the neural adaptations associated with training, by focusing on the behavior of single motor units. The review synthesizes current understanding on motor unit recruitment and rate coding during voluntary contractions, briefly describes the techniques used to record motor unit activity, and then evaluates the adaptations that have been observed in motor unit activity during maximal and submaximal contractions. Relatively few studies have directly compared motor unit behavior before and after training. Although some studies suggest that the voluntary activation of muscle can increase slightly with strength training, it is not known how the discharge of motor units changes to produce this increase in activation. The evidence indicates that the increase is not attributable to changes in motor unit synchronization. It has been demonstrated, however, that training can increase both the rate of torque development and the discharge rate of motor units. Furthermore, both strength training and practice of a force-matching task can evoke adaptations in the discharge characteristics of motor units. Because the variability in discharge rate has a significant influence on the fluctuations in force during submaximal contractions, the changes produced with training can influence motor performance during activities of daily living. Little is known, however, about the relative contributions of the descending drive, afferent feedback, spinal circuitry, and motor neuron properties to the observed adaptations in motor unit activity.

Nitrogen catabolite repression in yeasts and filamentous fungi.

Abstract: Publisher Summary This chapter provides a brief description of nitrogen catabolite repression in Saccharomyces cerevisiae. The ancestral use of yeasts in industry has led to the selection of many wild-type strains of Saccharomyces cerevisiae. Saccharomyces spp. are very different from bacteria, although in vegetative growth they can be handled in a similar way. This is probably the origin of the choice of these organisms when prokaryotic cellular physiologists became interested in eukaryotic organisms. Anabolism, catabolism, and regulation of arginine metabolism have also been studied in parallel in Saccharomyces cerevisiae. The chapter also discusses the nitrogen metabolite repression in filamentous fungi. A number of filamentous fungi are able to utilize a wide range of nitrogen sources. This metabolic versatility implies a strong selective pressure for a mechanism to ensure preferential utilization of the favorable nitrogen sources. This mechanism, nitrogen metabolite repression of the syntheses of many enzymes and permeases involved in nitrogen nutrition, has been extensively studied in two filamentous fungi, the ascomycetes Aspergillus nidulans and Neurospora crassa.