Institution
Université libre de Bruxelles
Education•Brussels, Belgium•
About: Université libre de Bruxelles is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Breast cancer. The organization has 24974 authors who have published 56969 publications receiving 2084303 citations. The organization is also known as: ULB.
Topics: Population, Breast cancer, Context (language use), Receptor, Cancer
Papers published on a yearly basis
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University of Melbourne1, Université Paris-Saclay2, New York University3, University of Milan4, Helsinki University Central Hospital5, University of Padua6, Indiana University – Purdue University Indianapolis7, Cornell University8, Harvard University9, European Institute of Oncology10, Université libre de Bruxelles11, Charité12
TL;DR: This pooled data analysis confirms the strong prognostic role of stromally located TILs in early-stage TNBC and excellent survival of patients with high sTILs after adjuvant chemotherapy and supports the integration of sTils in a clinicopathologic prognostic model for patients with TNBC.
Abstract: PurposeThe aim of the current study was to conduct a pooled analysis of studies that have investigated the prognostic value of tumor-infiltrating lymphocytes (TILs) in early-stage triple negative b...
440 citations
TL;DR: In this article, the universe is conceived as the response of matter and the gravitational field to a spontaneous point-like disturbance, and the history unfolds in two stages, creation and free expansion.
440 citations
TL;DR: This analysis further strengthens the previous recommendation to use TNM staging for all SCLC cases and assess the new IASLC proposals in this subtype of lung cancer.
440 citations
TL;DR: The findings are consistent with a CB1 cannabinoid receptor-dependent modulation of GABAergic postsynaptic currents, but a novel cannabinoid-sensitive receptor must be responsible for the inhibition of glutamatergic neurotransmission.
439 citations
TL;DR: The results indicate that silencing of the lineage addiction oncogene SAMMSON disrupts vital mitochondrial functions in a cancer-cell-specific manner and is expected to deliver highly effective and tissue-restricted anti-melanoma therapeutic responses.
Abstract: Focal amplifications of chromosome 3p13-3p14 occur in about 10% of melanomas and are associated with a poor prognosis. The melanoma-specific oncogene MITF resides at the epicentre of this amplicon. However, whether other loci present in this amplicon also contribute to melanomagenesis is unknown. Here we show that the recently annotated long non-coding RNA (lncRNA) gene SAMMSON is consistently co-gained with MITF. In addition, SAMMSON is a target of the lineage-specific transcription factor SOX10 and its expression is detectable in more than 90% of human melanomas. Whereas exogenous SAMMSON increases the clonogenic potential in trans, SAMMSON knockdown drastically decreases the viability of melanoma cells irrespective of their transcriptional cell state and BRAF, NRAS or TP53 mutational status. Moreover, SAMMSON targeting sensitizes melanoma to MAPK-targeting therapeutics both in vitro and in patient-derived xenograft models. Mechanistically, SAMMSON interacts with p32, a master regulator of mitochondrial homeostasis and metabolism, to increase its mitochondrial targeting and pro-oncogenic function. Our results indicate that silencing of the lineage addiction oncogene SAMMSON disrupts vital mitochondrial functions in a cancer-cell-specific manner; this silencing is therefore expected to deliver highly effective and tissue-restricted anti-melanoma therapeutic responses.
439 citations
Authors
Showing all 25206 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Karl J. Friston | 217 | 1267 | 217169 |
| Yi Chen | 217 | 4342 | 293080 |
| David Miller | 203 | 2573 | 204840 |
| Jing Wang | 184 | 4046 | 202769 |
| H. S. Chen | 179 | 2401 | 178529 |
| Jie Zhang | 178 | 4857 | 221720 |
| Jasvinder A. Singh | 176 | 2382 | 223370 |
| D. M. Strom | 176 | 3167 | 194314 |
| J. N. Butler | 172 | 2525 | 175561 |
| Andrea Bocci | 172 | 2402 | 176461 |
| Bradley Cox | 169 | 2150 | 156200 |
| Marc Weber | 167 | 2716 | 153502 |
| Hongfang Liu | 166 | 2356 | 156290 |
| Guenakh Mitselmakher | 165 | 1951 | 164435 |
| Yang Yang | 164 | 2704 | 144071 |