Université libre de Bruxelles

About: Université libre de Bruxelles is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Breast cancer. The organization has 24974 authors who have published 56969 publications receiving 2084303 citations. The organization is also known as: ULB.

Comprehensive nucleosynthesis analysis for ejecta of compact binary mergers

Abstract: We present the first comprehensive study of r-process element nucleosynthesis in the ejecta of compact binary mergers (CBMs) and their relic black hole (BH)–torus systems. The evolution of the BH–accretion tori is simulated for seconds with a Newtonian hydrodynamics code including viscosity effects, pseudo-Newtonian gravity for rotating BHs, and an energy-dependent two-moment closure scheme for the transport of electron neutrinos and antineutrinos. The investigated cases are guided by relativistic double neutron star (NS–NS) and NS–BH merger models, producing ∼3–6 M_⊙ BHs with rotation parameters of A_BH ∼ 0.8 and tori of 0.03–0.3 M_⊙. Our nucleosynthesis analysis includes the dynamical (prompt) ejecta expelled during the CBM phase and the neutrino and viscously driven outflows of the relic BH–torus systems. While typically ∼20–25 per cent of the initial accretion-torus mass are lost by viscously driven outflows, neutrino-powered winds contribute at most another ∼1 per cent, but neutrino heating enhances the viscous ejecta significantly. Since BH–torus ejecta possess a wide distribution of electron fractions (0.1–0.6) and entropies, they produce heavy elements from A ∼ 80 up to the actinides, with relative contributions of A ≳ 130 nuclei being subdominant and sensitively dependent on BH and torus masses and the exact treatment of shear viscosity. The combined ejecta of CBM and BH–torus phases can reproduce the solar abundances amazingly well for A ≳ 90. Varying contributions of the torus ejecta might account for observed variations of lighter elements with 40 ≤ Z ≤ 56 relative to heavier ones, and a considerable reduction of the prompt ejecta compared to the torus ejecta, e.g. in highly asymmetric NS–BH mergers, might explain the composition of heavy-element deficient stars.

A Racing Algorithm for Configuring Metaheuristics

Abstract: This paper describes a racing procedure for finding, in a limited amount of time, a configuration of a metaheuristic that performs as good as possible on a given instance class of a combinatorial optimization problem. Taking inspiration from methods proposed in the machine learning literature for model selection through cross-validation, we propose a procedure that empirically evaluates a set of candidate configurations by discarding bad ones as soon as statistically sufficient evidence is gathered against them. We empirically evaluate our procedure using as an example the configuration of an ant colony optimization algorithm applied to the traveling salesman problem. The experimental results show that our procedure is able to quickly reduce the number of candidates, and allows to focus on the most promising ones.

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Abstract: Free fatty acids (FFA) cause apoptosis of pancreatic beta-cells and might contribute to beta-cell loss in type 2 diabetes via the induction of endoplasmic reticulum (ER) stress. We studied here the molecular mechanisms implicated in FFA-induced ER stress initiation and apoptosis in INS-1E cells, FACS-purified primary beta-cells and human islets exposed to oleate and/or palmitate. Treatment with saturated and/or unsaturated FFA led to differential ER stress signaling. Palmitate induced more apoptosis and markedly activated the IRE1, PERK and ATF6 pathways, owing to a sustained depletion of ER Ca(2+) stores, whereas the unsaturated FFA oleate led to milder PERK and IRE1 activation and comparable ATF6 signaling. Non-metabolizable methyl-FFA analogs induced neither ER stress nor beta-cell apoptosis. The FFA-induced ER stress response was not modified by high glucose concentrations, suggesting that ER stress in primary beta-cells is primarily lipotoxic, and not glucolipotoxic. Palmitate, but not oleate, activated JNK. JNK inhibitors reduced palmitate-mediated AP-1 activation and apoptosis. Blocking the transcription factor CHOP delayed palmitate-induced beta-cell apoptosis. In conclusion, saturated FFA induce ER stress via ER Ca(2+) depletion. The IRE1 and resulting JNK activation contribute to beta-cell apoptosis. PERK activation by palmitate also contributes to beta-cell apoptosis via CHOP.

Description and performance of track and primary-vertex reconstruction with the CMS tracker

Abstract: A description is provided of the software algorithms developed for the CMS tracker both for reconstructing charged-particle trajectories in proton-proton interactions and for using the resulting tracks to estimate the positions of the LHC luminous region and individual primary-interaction vertices. Despite the very hostile environment at the LHC, the performance obtained with these algorithms is found to be excellent. For tt events under typical 2011 pileup conditions, the average track-reconstruction efficiency for promptly-produced charged particles with transverse momenta of p_T > 0.9GeV is 94% for pseudorapidities of |η| < 0.9 and 85% for 0.9 < |η| < 2.5. The inefficiency is caused mainly by hadrons that undergo nuclear interactions in the tracker material. For isolated muons, the corresponding efficiencies are essentially 100%. For isolated muons of p_T = 100GeV emitted at |η| < 1.4, the resolutions are approximately 2.8% in p_T, and respectively, 10μm and 30μm in the transverse and longitudinal impact parameters. The position resolution achieved for reconstructed primary vertices that correspond to interesting pp collisions is 10–12μm in each of the three spatial dimensions. The tracking and vertexing software is fast and flexible, and easily adaptable to other functions, such as fast tracking for the trigger, or dedicated tracking for electrons that takes into account bremsstrahlung.