Université libre de Bruxelles

About: Université libre de Bruxelles is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Breast cancer. The organization has 24974 authors who have published 56969 publications receiving 2084303 citations. The organization is also known as: ULB.

Global carbon budget 2014

Abstract: Accurate assessment of anthropogenic carbon dioxide (CO 2 ) emissions and their redistribution among the atmosphere, ocean, and terrestrial biosphere is important to better understand the global carbon cycle, support the development of climate policies, and project future climate change. Here we describe data sets and a methodology to quantify all major components of the global carbon budget, including their uncertainties, based on the combination of a range of data, algorithms, statistics, and model estimates and their interpretation by a broad scientific community. We discuss changes compared to previous estimates, consistency within and among components, alongside methodology and data limitations. CO 2 emissions from fossil fuel combustion and cement production (E FF ) are based on energy statistics and cement production data, respectively, while emissions from land-use change (E LUC ), mainly deforestation, are based on combined evidence from land-cover-change data, fire activity associated with deforestation, and models. The global atmospheric CO 2 concentration is measured directly and its rate of growth (G ATM ) is computed from the annual changes in concentration. The mean ocean CO 2 sink (S OCEAN ) is based on observations from the 1990s, while the annual anomalies and trends are estimated with ocean models. The variability in S OCEAN is evaluated with data products based on surveys of ocean CO 2 measurements. The global residual terrestrial CO 2 sink (S LAND ) is estimated by the difference of the other terms of the global carbon budget and compared to results of independent dynamic global vegetation models forced by observed climate, CO 2 , and land-cover-change (some including nitrogen–carbon interactions). We compare the mean land and ocean fluxes and their variability to estimates from three atmospheric inverse methods for three broad latitude bands. All uncertainties are reported as ±1σ, reflecting the current capacity to characterise the annual estimates of each component of the global carbon budget. For the last decade available (2004–2013), E FF was 8.9 ± 0.4 GtC yr −1 , E LUC 0.9 ± 0.5 GtC yr −1 , G ATM 4.3 ± 0.1 GtC yr −1 , S OCEAN 2.6 ± 0.5 GtC yr −1 , and S LAND 2.9 ± 0.8 GtC yr −1 . For year 2013 alone, E FF grew to 9.9 ± 0.5 GtC yr −1 , 2.3% above 2012, continuing the growth trend in these emissions, E LUC was 0.9 ± 0.5 GtC yr −1 , G ATM was 5.4 ± 0.2 GtC yr −1 , S OCEAN was 2.9 ± 0.5 GtC yr −1 and S LAND was 2.5 ± 0.9 GtC yr −1 . G ATM was high in 2013, reflecting a steady increase in E FF and smaller and opposite changes between S OCEAN and S LAND compared to the past decade (2004–2013). The global atmospheric CO 2 concentration reached 395.31 ± 0.10 ppm averaged over 2013. We estimate that E FF will increase by 2.5% (1.3–3.5%) to 10.1 ± 0.6 GtC in 2014 (37.0 ± 2.2 GtCO 2 yr −1 ), 65% above emissions in 1990, based on projections of world gross domestic product and recent changes in the carbon intensity of the global economy. From this projection of E FF and assumed constant E LUC for 2014, cumulative emissions of CO 2 will reach about 545 ± 55 GtC (2000 ± 200 GtCO 2 ) for 1870–2014, about 75% from EF FF and 25% from E LUC . This paper documents changes in the methods and data sets used in this new carbon budget compared with previous publications of this living data set (Le Quere et al., 2013, 2014). All observations presented here can be downloaded from the Carbon Dioxide Information Analysis Center (doi:10.3334/CDIAC/GCP_2014).

Hypopigmenting agents: an updated review on biological, chemical and clinical aspects

Abstract: An overview of agents causing hypopigmentation in human skin is presented. The review is organized to put forward groups of biological and chemical agents. Their mechanisms of action cover (i) tyrosinase inhibition, maturation and enhancement of its degradation; (ii) Mitf inhibition; (iii) downregulation of MC1R activity; (iv) interference with melanosome maturation and transfer; (v) melanocyte loss, desquamation and chemical peeling. Tyrosinase inhibition is the most common approach to achieve skin hypopigmentation as this enzyme catalyses the rate-limiting step of pigmentation. Despite the large number of tyrosinase inhibitors in vitro, only a few are able to induce effects in clinical trials. The gap between in-vitro and in-vivo studies suggests that innovative strategies are needed for validating their efficacy and safety. Successful treatments need the combination of two or more agents acting on different mechanisms to achieve a synergistic effect. In addition to tyrosinase inhibition, other parameters related to cytotoxicity, solubility, cutaneous absorption, penetration and stability of the agents should be considered. The screening test system is also very important as keratinocytes play an active role in modulating melanogenesis within melanocytes. Mammalian skin or at least keratinocytes/melanocytes co-cultures should be preferred rather than pure melanocyte cultures or soluble tyrosinase.

A survey on metaheuristics for stochastic combinatorial optimization

Abstract: Metaheuristics are general algorithmic frameworks, often nature-inspired, designed to solve complex optimization problems, and they are a growing research area since a few decades. In recent years, metaheuristics are emerging as successful alternatives to more classical approaches also for solving optimization problems that include in their mathematical formulation uncertain, stochastic, and dynamic information. In this paper metaheuristics such as Ant Colony Optimization, Evolutionary Computation, Simulated Annealing, Tabu Search and others are introduced, and their applications to the class of Stochastic Combinatorial Optimization Problems (SCOPs) is thoroughly reviewed. Issues common to all metaheuristics, open problems, and possible directions of research are proposed and discussed. In this survey, the reader familiar to metaheuristics finds also pointers to classical algorithmic approaches to optimization under uncertainty, and useful informations to start working on this problem domain, while the reader new to metaheuristics should find a good tutorial in those metaheuristics that are currently being applied to optimization under uncertainty, and motivations for interest in this field.

Self-organization in social insects.

Abstract: Self-organization was introduced originally in the context of physics and chemistry to describe how microscopic processes give rise to macroscopic stuctures in out-of-equilibrium systems, Recent research that extends this concept to ethology suggests that it provides a concise description of a wide range of collective phenomena in animals, especially in social insects. This description does not rely on individual complexity to account for complex spatiotemporal features that emerge at the colony level, but rather assumes that intractions among simple individuals can produce highly structured collective behaviours.