Institution
Université libre de Bruxelles
Education•Brussels, Belgium•
About: Université libre de Bruxelles is a education organization based out in Brussels, Belgium. It is known for research contribution in the topics: Population & Breast cancer. The organization has 24974 authors who have published 56969 publications receiving 2084303 citations. The organization is also known as: ULB.
Topics: Population, Breast cancer, Context (language use), Receptor, Cancer
Papers published on a yearly basis
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TL;DR: The authors analyzes the interaction between aggregate efficiency, corruption, and other dimensions of governance for a panel of 69 countries, both developed and developing, and finds that corruption is less detrimental to efficiency in countries where institutions are less effective.
497 citations
University of Milan1, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico2, University of Bologna3, Humanitas University4, University of Milano-Bicocca5, National University of Ireland, Galway6, University of Turin7, Boston Children's Hospital8, Université libre de Bruxelles9, Catholic University of the Sacred Heart10, St. Michael's Hospital11
TL;DR: Patients with COVID-19-associated ARDS have a form of injury that, in many aspects, is similar to that of those with ARDS unrelated to CO VID-19, who have a reduction in respiratory system compliance together with increased D-dimer concentrations have high mortality rates.
496 citations
01 Nov 1994
TL;DR: The fundamental characteristics of multicriteria problems are recalled and requisites are formulated for an appropriate multicritera decision aid methodology, including newer developments such as PROMETHEE V (multicriteria optimization under constraints) and the GAIA visual modelling method.
Abstract: PROMCALC & GAIA is the last development of the interactive decision support system based on the PROMETHEE and GAIA methodology. In the first section, the fundamental characteristics of multicriteria problems are recalled and requisites are formulated for an appropriate multicriteria decision aid methodology. Based on these requisites, the PROMETHEE methods are then introduced, including newer developments such as PROMETHEE V (multicriteria optimization under constraints) and the GAIA visual modelling method. The actual implementation of the proposed methodology in the PROMCALC & GAIA software is then detailed and a numerical example is developed to illustrate the possibilities of the system.
495 citations
New York University1, Queen Mary University of London2, University of California, San Francisco3, Harvard University4, Curie Institute5, Université libre de Bruxelles6, Princess Margaret Cancer Centre7, University of Chicago8, University of Sydney9, University of Milan10, European Institute of Oncology11, Rutgers University12, Texas Oncology13, Baylor University Medical Center14, Peter MacCallum Cancer Centre15, Sheba Medical Center16, Merck & Co.17
TL;DR: Pembrolizumab monotherapy demonstrated durable antitumor activity in a subset of patients with previously treated mTNBC and had a manageable safety profile.
494 citations
TL;DR: The contact hemolytic activity of Shigella flexneri was used to investigate its putative translocator and electron microscopy analysis indicated that secretons were constitutively assembled at 37°C before any host contact.
Abstract: Bacterial type III secretion systems serve to translocate proteins into eukaryotic cells, requiring a secreton and a translocator for proteins to pass the bacterial and host membranes. We used the contact hemolytic activity of Shigella flexneri to investigate its putative translocator. Hemolysis was caused by formation of a 25-A pore within the red blood cell (RBC) membrane. Of the five proteins secreted by Shigella upon activation of its type III secretion system, only the hydrophobic IpaB and IpaC were tightly associated with RBC membranes isolated after hemolysis. Ipa protein secretion and hemolysis were kinetically coupled processes. However, Ipa protein secretion in the immediate vicinity of RBCs was not sufficient to cause hemolysis in the absence of centrifugation. Centrifugation reduced the distance between bacterial and RBC membranes beyond a critical threshold. Electron microscopy analysis indicated that secretons were constitutively assembled at 37°C before any host contact. They were composed of three parts: (a) an external needle, (b) a neck domain, and (c) a large proximal bulb. Secreton morphology did not change upon activation of secretion. In mutants of some genes encoding the secretion machinery the organelle was absent, whereas ipaB and ipaC mutants displayed normal secretons.
494 citations
Authors
Showing all 25206 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Karl J. Friston | 217 | 1267 | 217169 |
| Yi Chen | 217 | 4342 | 293080 |
| David Miller | 203 | 2573 | 204840 |
| Jing Wang | 184 | 4046 | 202769 |
| H. S. Chen | 179 | 2401 | 178529 |
| Jie Zhang | 178 | 4857 | 221720 |
| Jasvinder A. Singh | 176 | 2382 | 223370 |
| D. M. Strom | 176 | 3167 | 194314 |
| J. N. Butler | 172 | 2525 | 175561 |
| Andrea Bocci | 172 | 2402 | 176461 |
| Bradley Cox | 169 | 2150 | 156200 |
| Marc Weber | 167 | 2716 | 153502 |
| Hongfang Liu | 166 | 2356 | 156290 |
| Guenakh Mitselmakher | 165 | 1951 | 164435 |
| Yang Yang | 164 | 2704 | 144071 |