University of Groningen

About: University of Groningen is a education organization based out in Groningen, Groningen, Netherlands. It is known for research contribution in the topics: Population & Context (language use). The organization has 36346 authors who have published 69116 publications receiving 2940370 citations. The organization is also known as: Rijksuniversiteit Groningen & RUG.

Many Labs 2: Investigating Variation in Replicability Across Samples and Settings

Abstract: We conducted preregistered replications of 28 classic and contemporary published findings, with protocols that were peer reviewed in advance, to examine variation in effect magnitudes across samples and settings. Each protocol was administered to approximately half of 125 samples that comprised 15,305 participants from 36 countries and territories. Using the conventional criterion of statistical significance (p < .05), we found that 15 (54%) of the replications provided evidence of a statistically significant effect in the same direction as the original finding. With a strict significance criterion (p < .0001), 14 (50%) of the replications still provided such evidence, a reflection of the extremely high-powered design. Seven (25%) of the replications yielded effect sizes larger than the original ones, and 21 (75%) yielded effect sizes smaller than the original ones. The median comparable Cohen’s ds were 0.60 for the original findings and 0.15 for the replications. The effect sizes were small (< 0.20) in 16 of the replications (57%), and 9 effects (32%) were in the direction opposite the direction of the original effect. Across settings, the Q statistic indicated significant heterogeneity in 11 (39%) of the replication effects, and most of those were among the findings with the largest overall effect sizes; only 1 effect that was near zero in the aggregate showed significant heterogeneity according to this measure. Only 1 effect had a tau value greater than .20, an indication of moderate heterogeneity. Eight others had tau values near or slightly above .10, an indication of slight heterogeneity. Moderation tests indicated that very little heterogeneity was attributable to the order in which the tasks were performed or whether the tasks were administered in lab versus online. Exploratory comparisons revealed little heterogeneity between Western, educated, industrialized, rich, and democratic (WEIRD) cultures and less WEIRD cultures (i.e., cultures with relatively high and low WEIRDness scores, respectively). Cumulatively, variability in the observed effect sizes was attributable more to the effect being studied than to the sample or setting in which it was studied.

Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder

Abstract: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are both highly heritable neurodevelopmental disorders. Evidence indicates both disorders co-occur with a high frequency, in 20–50% of children with ADHD meeting criteria for ASD and in 30-80% of ASD children meeting criteria for ADHD. This review will provide an overview on all available studies [family based, twin, candidate gene, linkage, and genome wide association (GWA) studies] shedding light on the role of shared genetic underpinnings of ADHD and ASD. It is concluded that family and twin studies do provide support for the hypothesis that ADHD and ASD originate from partly similar familial/genetic factors. Only a few candidate gene studies, linkage studies and GWA studies have specifically addressed this co-occurrence, pinpointing to some promising pleiotropic genes, loci and single nucleotide polymorphisms (SNPs), but the research field is in urgent need for better designed and powered studies to tackle this complex issue. We propose that future studies examining shared familial etiological factors for ADHD and ASD use a family-based design in which the same phenotypic (ADHD and ASD), candidate endophenotypic, and environmental measurements are obtained from all family members. Multivariate multi-level models are probably best suited for the statistical analysis.

The absence of crystalline silicates in the diffuse interstellar medium

Abstract: Infrared spectroscopy provides a direct handle on the composition and structure of interstellar dust. We have studied the dust along the line of sight toward the Galactic center using Short Wavelength Spectrometer data obtained with the Infrared Space Observatory (ISO). We focused on the wavelength region from 8 to 13 μm, which is dominated by the strong silicate absorption feature. Using the absorption profiles observed toward Galactic center sources 3 and 4, which are C-rich Wolf-Rayet Stars, as reference objects, we are able to disentangle the interstellar silicate absorption and the silicate emission intrinsic to the source, toward Sgr A* and derive a very accurate profile for the intrinsic 9.7 μm band. The interstellar absorption band is smooth and featureless and is well reproduced using a mixture of 15.1% amorphous pyroxene and 84.9% of amorphous olivine by mass, all in spherical submicron-sized grains. There is no direct evidence for substructure due to interstellar crystalline silicates. By minimizing χ2 of spectral fits to the absorption feature, we are able to determine an upper limit to the degree of crystallinity of silicates in the diffuse interstellar medium (ISM) and conclude that the crystalline fraction of the interstellar silicates is 0.2% ± 0.2% by mass. This is much lower than the degree of crystallinity observed in silicates in the circumstellar environment of evolved stars, the main contributors of dust to the ISM. There are two possible explanations for this discrepancy. First, an amorphization process occurs in the ISM on a timescale significantly shorter than the destruction timescale, possibly caused by particle bombardment by heavyweight ions. Second, we consider the possibility that the crystalline silicates in stellar ejecta are diluted by an additional source of amorphous silicates, in particular supernovae. We also compare our results with a study on silicate presolar grains found in interplanetary dust particles.