University of Groningen

About: University of Groningen is a education organization based out in Groningen, Groningen, Netherlands. It is known for research contribution in the topics: Population & Context (language use). The organization has 36346 authors who have published 69116 publications receiving 2940370 citations. The organization is also known as: Rijksuniversiteit Groningen & RUG.

Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

Abstract: Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p<3×10(-4)). We next developed a multi-SNP genotypic risk score to test the association of adiponectin decreasing risk alleles on metabolic traits and diseases using consortia-level meta-analytic data. This risk score was associated with increased risk of T2D (p = 4.3×10(-3), n = 22,044), increased triglycerides (p = 2.6×10(-14), n = 93,440), increased waist-to-hip ratio (p = 1.8×10(-5), n = 77,167), increased glucose two hours post oral glucose tolerance testing (p = 4.4×10(-3), n = 15,234), increased fasting insulin (p = 0.015, n = 48,238), but with lower in HDL-cholesterol concentrations (p = 4.5×10(-13), n = 96,748) and decreased BMI (p = 1.4×10(-4), n = 121,335). These findings identify novel genetic determinants of adiponectin levels, which, taken together, influence risk of T2D and markers of insulin resistance.

Electronic structure of MoSe2, MoS2, and WSe2. I. Band-structure calculations and photoelectron spectroscopy

Abstract: The band structures of the semiconducting layered compounds ${\mathrm{MoSe}}_{2}$, ${\mathrm{MoS}}_{2}$, and ${\mathrm{WSe}}_{2}$ have been calculated self-consistently with the augmented-spherical-wave method. Angle-resolved photoelec- tron spectroscopy of ${\mathrm{MoSe}}_{2}$ using He i, He ii, and Ne i radiation, and photon-energy-dependent normal-emission photoelectron spectroscopy using synchrotron radiation, show that the calculational results give a good description of the valence-band structure. At about 1 eV below the top of the valence band a dispersionless state was measured, almost completely of Mo 4d character. Such a state, which is not predicted by band-structure calculations, has also been observed in metallic layered compounds. Suggestions are given for the explanation of this phenomenon.

An alternative bactericidal mechanism of action for lantibiotic peptides that target lipid II

Abstract: Lantibiotics are polycyclic peptides containing unusual amino acids, which have binding specificity for bacterial cells, targeting the bacterial cell wall component lipid II to form pores and thereby lyse the cells. Yet several members of these lipid II-targeted lantibiotics are too short to be able to span the lipid bilayer and cannot form pores, but somehow they maintain their antibacterial efficacy. We describe an alternative mechanism by which members of the lantibiotic family kill Gram-positive bacteria by removing lipid II from the cell division site (or septum) and thus block cell wall synthesis.

The afterglow, redshift and extreme energetics of the γ-ray burst of 23 January 1999

Abstract: Long-lived emission, known as afterglow, has now been detected from about a dozen γ-ray bursts. Distance determinations place the bursts at cosmological distances, with redshifts, z, ranging from ∼1 to 3. The energy required to produce these bright γ-ray flashes is enormous: up to ∼1053 erg, or 10 per cent of the rest-mass energy of a neutron star, if the emission is isotropic. Here we present optical and near-infrared observations of the afterglow of GRB990123, and we determine a redshift of z ⩾ 1.6. This is to date the brightest γ-ray burst with a well-localized position and if the γ-rays were emitted isotropically, the energy release exceeds the rest-mass energy of a neutron star, so challenging current theoretical models of the sources. We argue, however, that our data may provide evidence of beamed (rather than isotropic) radiation, thereby reducing the total energy released to a level where stellar-death models are still tenable.