University of Houston

About: University of Houston is a education organization based out in Houston, Texas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 23074 authors who have published 53903 publications receiving 1641968 citations.

The Genome Sequence of Taurine Cattle: A Window to Ruminant Biology and Evolution

Abstract: To understand the biology and evolution of ruminants, the cattle genome was sequenced to about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a core set of 14,345 orthologs shared among seven mammalian species of which 1217 are absent or undetected in noneutherian (marsupial or monotreme) genomes. Cattle-specific evolutionary breakpoint regions in chromosomes have a higher density of segmental duplications, enrichment of repetitive elements, and species-specific variations in genes associated with lactation and immune responsiveness. Genes involved in metabolism are generally highly conserved, although five metabolic genes are deleted or extensively diverged from their human orthologs. The cattle genome sequence thus provides a resource for understanding mammalian evolution and accelerating livestock genetic improvement for milk and meat production.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Abstract: In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field.

Evidence for superconductivity above 40 K in the La-Ba-Cu-O compound system.

Abstract: An apparent superconducting transition with an onset temperature above 40 K has been detected under pressure in the La-Ba-Cu-O compound system synthesized directly from a solid-state reaction of La2O3, CuO, and BaCO3 followed by a decomposition of the mixture in a reduced atmosphere. The experiment is described and the results of effects of magnetic field and pressure are discussed.

Coherent structures and turbulence.

Abstract: This is a personal statement on the present state of understanding of coherent structures, in particular their spatial details and dynamical significance. The characteristic measures of coherent structures are discussed, emphasizing coherent vorticity as the crucial property. We present here a general scheme for educing structures in any transitional or fully turbulent flow. From smoothed vorticity maps in convenient flow planes, this scheme recognizes patterns of the same mode and parameter size, and then phase-aligns and ensemble-averages them to obtain coherent structure measures. The departure of individual realizations from the ensemble average denotes incoherent turbulence. This robust scheme has been used to educe structures from velocity data using a rake of hot wires as well as direct numerical simulations and can educe structures using newer measurement techniques such as digital image processing. Our recent studies of coherent structures in several free shear flows are briefly reviewed. Detailed data in circular and elliptic jets, mixing layers, and a plane wake reveal that incoherent turbulence is produced at the ‘saddles’ and then advected to the ‘centres’ of the structures. The mechanism of production of turbulence in shear layers is the stretching of longitudinal vortices or ‘ribs’ which connect the predominantly spanwise ‘rolls’; the ribs induce spanwise contortions of rolls and cause mixing and dissipation, mostly at points where they connect with rolls. We also briefly discuss the role of coherent structures in aerodynamic noise generation and argue that the structure breakdown process, rather than vortex pairing, is the dominant mechanism of noise generation. The ‘cut-and-connect’ interaction of coherent structures is proposed as a specific mechanism of aerodynamic noise generation, and a simple analytical model of it shows that it can provide acceptable predictions of jet noise. The coherent-structures approach to turbulence, apart from explaining flow physics, has also enabled turbulence management via control of structure evolution and interactions. We also discuss some new ideas under investigation: in particular, helicity as a characteristic property of coherent structures.