University of Luxembourg

About: University of Luxembourg is a education organization based out in Luxembourg, Luxembourg. It is known for research contribution in the topics: Context (language use) & Computer science. The organization has 4744 authors who have published 22175 publications receiving 381824 citations.

miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers

Abstract: Epithelial to mesenchymal transition (EMT) is a key step toward metastasis. MCF7 breast cancer cells conditionally expressing the EMT master regulator SNAI1 were used to identify early expressed microRNAs (miRNAs) and their targets that may contribute to the EMT process. Potential targets of miRNAs were identified by matching lists of in silico predicted targets and of inversely expressed mRNAs. MiRNAs were ranked based on the number of predicted hits, highlighting miR-661, a miRNA with so far no reported role in EMT. MiR-661 was found required for efficient invasion of breast cancer cells by destabilizing two of its predicted mRNA targets, the cell-cell adhesion protein Nectin-1 and the lipid transferase StarD10, resulting, in turn, in the downregulation of epithelial markers. Reexpression of Nectin-1 or StarD10 lacking the 3'-untranslated region counteracted SNAI1-induced invasion. Importantly, analysis of public transcriptomic data from a cohort of 295 well-characterized breast tumor specimen revealed that expression of StarD10 is highly associated with markers of luminal subtypes whereas its loss negatively correlated with the EMT-related, basal-like subtype. Collectively, our non-a priori approach revealed a nonpredicted link between SNAI1-triggered EMT and the down-regulation of Nectin-1 and StarD10 through the up-regulation of miR-661, which may contribute to the invasion of breast cancer cells and poor disease outcome.

Time, Emotion and the Embodiment of Timing

Abstract: The past few decades have seen an explosion in studies exploring the effects of emotion on time judgments. The aim of this review is to describe the results of these studies and to look at how they try to explain the time distortions produced by emotion. We begin by examining the findings on time judgments in affective disorders, which allow us to make a clear distinction between the feelings of time distortion that originate from introspection onto subjective personal experience, and the effects of emotion on the basic mechanisms involved in time perception. We then report the results of behavioral studies that have tested the effects of emotions on time perceptions and the temporal processing of different emotional stimuli (e.g. facial expressions, affective pictures or sounds). Finally, we describe our own studies of the embodiment of timing. Overall, the different results on time and emotion suggest that temporal distortions are an indicator of how our brain and body adapt to the dynamic structure of our environment.

Banking on Stability: The Political Economy of New Capital Requirements in the European Union

Abstract: The Basel III Accord on a ‘Global regulatory framework for more resilient banks and banking systems’ was issued in late 2010 as the cornerstone of the international regulatory response to the global financial crisis. Its adoption into European Union (EU) legislation has, however, been met with considerable member state reticence and intra-EU negotiations are ongoing. This paper investigates the political economy of new capital requirements in the EU, arguing that the institutional features of national banking sectors convincingly account for the divergence in EU member state preferences on capital rules.

Decentralized Traffic Aware Scheduling for multi-hop Low power Lossy Networks in the Internet of Things

Abstract: The emerging IEEE802.15.4e standard and IETF RPL routing protocol are core to the organization of multi-hop Low-power and Lossy Networks. They provide key functionalities useful for a really viable Internet of Things. However, several open issues still remain and require research efforts to be solved. Among others, the design of effective scheduling schemes in such systems is one of the major problems; in fact, there are no specifications about how schedules should be realized. Trying to fill this gap, this paper presents a new Decentralized Traffic-Aware Scheduling algorithm, which is able to construct optimum multi-hop schedules in a distributed fashion. Its effectiveness has been proved by using simulation results and comparing it with a centralized scheme. The reported performance results encourage the use of the developed scheduling technique, since it allows a very efficient queue management, and thus it minimizes packet discards due to buffer overflows, while at the same time minimizing the network duty cycle.