University of Luxembourg

About: University of Luxembourg is a education organization based out in Luxembourg, Luxembourg. It is known for research contribution in the topics: Context (language use) & Computer science. The organization has 4744 authors who have published 22175 publications receiving 381824 citations.

Performance Limits of Cognitive-Uplink FSS and Terrestrial FS for Ka-Band

Abstract: This paper investigates the performance limits of cognitive-uplink fixed satellite service (FSS) and terrestrial fixed service (FS) operating in the range 27.5–29.5 GHz for Ka-band. In light of standard recommendations from the International Telecommunications Union and a rain-fading channel model, we analyze the interference level at the FS receiver by considering statistical properties of the channel, propagation losses, and antenna patterns. By employing the interference constraint criterion at the FS, an analytical expression for the capacity of the cognitive-uplink FSS is derived, which is useful in understanding the limits in performance and the potential application of the considered coexistence scenario. Simulations are carried out to verify the theoretical derivations and highlight the impact of key parameters on the performance limits.

Opportunistic DTN routing with window-aware adaptive replication

Abstract: This paper presents ORWAR, a resource-efficient protocol for opportunistic routing in delay-tolerant networks. Our approach exploits the context of mobile nodes (speed, direction of movement and radio range) to estimate the size of a contact window. This knowledge is exploited to make better forwarding decisions and to minimize the probability of partially transmitted messages. As well as optimizing the use of bandwidth during overloads it helps to reduce energy consumption since partially transmitted messages are useless and waste transmission power. Another feature of the algorithm is the use of a differentiation mechanism based on message utility. This allows allocating more resources for high utility messages. More precisely, messages are replicated in the order of highest utility first, and removed from the buffers in the reverse order. To illustrate the benefit of such a scheme the global accumulated utility is used as a system-wide performance metric. Simulations illustrate the benefit of our model and show that ORWAR provides lower overhead and higher delivery rate, as well as higher accumulated utility compared to a number of well-known algorithms (including Maxprop and SprayAndWait).

The Emergent European Model in Skill Formation: Comparing Higher Education and Vocational Training in the Bologna and Copenhagen Processes.

Abstract: Proposing an alternative to the American model, intergovernmental reform initiatives in Europe have developed and promote a comprehensive European model of skill formation. What ideals, standards, and governance are proposed in this new pan-European model? This model responds to heightened global competition among “knowledge societies” as it challenges national systems to improve. The authors thus compare this emergent European model with the historically influential models of Germany, France, Great Britain, and the United States. To what extent does the European model resemble these traditionally influential national models? The authors report findings of a theory-guided content analysis of official European policy documents in higher education and vocational training from 1998 to 2010. They find that while the European model is a bricolage that integrates diverse characteristics of influential models, the ambitious goals and standards codified in the twin Bologna and Copenhagen processes in higher educa...

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

Abstract: Fanconi anaemia (FA) is a recessive disorder characterized by genomic instability, congenital abnormalities, cancer predisposition and bone marrow (BM) failure. However, the pathogenesis of FA is not fully understood partly due to the limitations of current disease models. Here, we derive integration free-induced pluripotent stem cells (iPSCs) from an FA patient without genetic complementation and report in situ gene correction in FA-iPSCs as well as the generation of isogenic FANCA-deficient human embryonic stem cell (ESC) lines. FA cellular phenotypes are recapitulated in iPSCs/ESCs and their adult stem/progenitor cell derivatives. By using isogenic pathogenic mutation-free controls as well as cellular and genomic tools, our model serves to facilitate the discovery of novel disease features. We validate our model as a drug-screening platform by identifying several compounds that improve hematopoietic differentiation of FA-iPSCs. These compounds are also able to rescue the hematopoietic phenotype of FA patient BM cells.