University of Luxembourg

About: University of Luxembourg is a education organization based out in Luxembourg, Luxembourg. It is known for research contribution in the topics: Context (language use) & Computer science. The organization has 4744 authors who have published 22175 publications receiving 381824 citations.

Data driven discovery of cyber physical systems.

Abstract: Cyber-physical systems embed software into the physical world. They appear in a wide range of applications such as smart grids, robotics, and intelligent manufacturing. Cyber-physical systems have proved resistant to modeling due to their intrinsic complexity arising from the combination of physical and cyber components and the interaction between them. This study proposes a general framework for discovering cyber-physical systems directly from data. The framework involves the identification of physical systems as well as the inference of transition logics. It has been applied successfully to a number of real-world examples. The novel framework seeks to understand the underlying mechanism of cyber-physical systems as well as make predictions concerning their state trajectories based on the discovered models. Such information has been proven essential for the assessment of the performance of cyber-physical systems; it can potentially help debug in the implementation procedure and guide the redesign to achieve the required performance.

Symbol-Level and Multicast Precoding for Multiuser Multiantenna Downlink: A State-of-the-Art, Classification, and Challenges

Abstract: Precoding has been conventionally considered as an effective means of mitigating or exploiting the interference in the multiantenna downlink channel, where multiple users are simultaneously served with independent information over the same channel resources. The early works in this area were focused on transmitting an individual information stream to each user by constructing weighted linear combinations of symbol blocks (codewords). However, more recent works have moved beyond this traditional view by: 1) transmitting distinct data streams to groups of users and 2) applying precoding on a symbol-per-symbol basis. In this context, the current survey presents a unified view and classification of precoding techniques with respect to two main axes: 1) the switching rate of the precoding weights, leading to the classes of block-level and symbol-level precoding and 2) the number of users that each stream is addressed to, hence unicast, multicast, and broadcast precoding. Furthermore, the classified techniques are compared through representative numerical results to demonstrate their relative performance and uncover fundamental insights. Finally, a list of open theoretical problems and practical challenges are presented to inspire further research in this area 1 . 1 The concepts of precoding and beamforming are used interchangeably throughout this paper.

TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase.

Abstract: Polymerase basic protein 1 (PB1) is the catalytic core of the influenza A virus (IAV) RNA polymerase complex essential for viral transcription and replication. Understanding the intrinsic mechanisms which block PB1 function could stimulate development of new anti-influenza therapeutics. Affinity purification coupled with mass spectrometry (AP-MS) was used to identify host factors interacting with PB1. Among PB1 interactors, the E3 ubiquitin ligase TRIM32 interacts with PB1 proteins derived from multiple IAV strains. TRIM32 senses IAV infection by interacting with PB1 and translocates with PB1 to the nucleus following influenza infection. Ectopic TRIM32 expression attenuates IAV infection. Conversely, RNAi depletion and knockout of TRIM32 increase susceptibility of tracheal and lung epithelial cells to IAV infection. Reconstitution of trim32-/- mouse embryonic fibroblasts with TRIM32, but not a catalytically inactive mutant, restores viral restriction. Furthermore, TRIM32 directly ubiquitinates PB1, leading to PB1 protein degradation and subsequent reduction of polymerase activity. Thus, TRIM32 is an intrinsic IAV restriction factor which senses and targets the PB1 polymerase for ubiquitination and protein degradation. TRIM32 represents a model of intrinsic immunity, in which a host protein directly senses and counters viral infection in a species specific fashion by directly limiting viral replication.

Cellular and Molecular Characterization of Microglia : A Unique Immune Cell Population

Abstract: Microglia are essential for the development and function of the adult brain. Microglia arise from erythro-myeloid precursors in the yolk sac and populate the brain rudiment early during development. Unlike monocytes that are constantly renewed from bone marrow hematopoietic stem cells throughout life, resident microglia in the healthy brain persist during adulthood via constant self-renewal. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system, make microglia a unique cell population. Supporting this notion, recent genome-wide transcriptional studies revealed specific gene expression profiles clearly distinct from other brain and peripheral immune cells. Here, we highlight the breakthrough studies that, over the last decades, helped elucidate microglial cell identity, ontogeny, and function. We describe the main techniques that have been used for this task and outline the crucial milestones that have been achieved to reach our actual knowledge of microglia. Furthermore, we give an overview of the "microgliome" that is currently emerging thanks to the constant progress in the modern profiling techniques.

Promises and Limits of Web-deliberation

Abstract: Does the increasing usage of online political forums lead to a more deliberative democracy? This book answers to this question by presenting the evolution of the public spaces in a historical perspective, by defining and operationalizing the deliberative criteria of democracy, and by measuring and evaluating the impact of virtualization of the political debates under threes perspectives. It looks at the extent to which different categories of the population debate online, it looks at the categories of actors hosting online political forum, and it assesses the quality of the online political debates in different contexts. The final aim of this work is to provide a more balanced evaluation of the impact of virtualization of the political debates and to enrich the evolving deliberative theory with new findings.