Institution
University of Nice Sophia Antipolis
Education•Nice, France•
About: University of Nice Sophia Antipolis is a education organization based out in Nice, France. It is known for research contribution in the topics: Population & Stars. The organization has 10291 authors who have published 19964 publications receiving 680762 citations. The organization is also known as: UNS & University of Nice-Sophia Antipolis.
Topics: Population, Stars, Context (language use), Galaxy, Planet
Papers published on a yearly basis
Papers
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Katholieke Universiteit Leuven1, French Institute of Health and Medical Research2, University of Burgundy3, Rutgers University4, Vrije Universiteit Brussel5, University of Manchester6, University of Erlangen-Nuremberg7, Sapienza University of Rome8, Université catholique de Louvain9, University of Salento10, Charles University in Prague11, University of Tübingen12, Medical University of Warsaw13, Pasteur Institute14, Harvard University15, University of Helsinki16, National Institutes of Health17, Ghent University18, University of Strasbourg19, University of Graz20, Vita-Salute San Raffaele University21, University of Queensland22, Tuscia University23, Technische Universität München24, University of Nice Sophia Antipolis25, University of Turin26, QIMR Berghofer Medical Research Institute27, Université de Montréal28, Ludwig Institute for Cancer Research29
TL;DR: The main molecular, immunological, preclinical, and clinical aspects of ICD are summarized and tabulate in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.
Abstract: The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other immunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.
304 citations
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INAF1, University of Milan2, Aix-Marseille University3, Roma Tre University4, University of Nice Sophia Antipolis5, Academia Sinica6, University of Geneva7, University of Bologna8, University of Edinburgh9, Institut d'Astrophysique de Paris10, Jan Kochanowski University11, Nagoya University12, Jagiellonian University13, Max Planck Society14, University of Portsmouth15
TL;DR: The VIMOS Public Extragalactic Redshift Survey (VIPERS) as discussed by the authors was designed to address a broad range of problems in large-scale structure and galaxy evolution, thanks to a unique combination of volume and sampling rate, comparable to state-of-the-art surveys of the local Universe, together with extensive multi-band optical and near-infrared photometry.
Abstract: We describe the construction and general features of VIPERS, the VIMOS Public Extragalactic Redshift Survey. This `Large Programme' has been using the ESO VLT with the aim of building a spectroscopic sample of ~100,000 galaxies with i_{AB}<22.5 and 0.5
304 citations
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TL;DR: The timeline of 100 years of radiotherapy is reviewed with a focus on breakthroughs in the physics of radi therapy and technology during the past two decades, and the associated clinical benefits.
Abstract: Radiotherapy has been driven by constant technological advances since the discovery of X-rays in 1895. Radiotherapy aims to sculpt the optimal isodose on the tumour volume while sparing normal tissues. The benefits are threefold: patient cure, organ preservation and cost-efficiency. The efficacy and tolerance of radiotherapy were demonstrated by randomized trials in many different types of cancer (including breast, prostate and rectum) with a high level of scientific evidence. Such achievements, of major importance for the quality of life of patients, have been fostered during the past decade by linear accelerators with computer-assisted technology. More recently, these developments were augmented by proton and particle beam radiotherapy, usually combined with surgery and medical treatment in a multidisciplinary and personalized strategy against cancer. This article reviews the timeline of 100 years of radiotherapy with a focus on breakthroughs in the physics of radiotherapy and technology during the past two decades, and the associated clinical benefits.
304 citations
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TL;DR: The results demonstrate that contrary to the findings of earlier electrophysiologic studies carried out on ventral tegmental area dopaminergic neurons, changes in the release of dopamine in projection areas occur across the sleep–wake cycle.
Abstract: We used intracerebral microdialysis coupled with electrophysiologic recordings to determine relative changes in the concentrations of several neurotransmitters in the medial prefrontal cortex and nucleus accumbens of freely moving rats during waking, slow-wave sleep, and rapid eye movement (REM) sleep. The concentrations of noradrenaline, dopamine, glutamate, and aspartate in 2-min dialysate samples were analyzed by capillary electrophoresis combined with laser-induced fluorescence detection. Changes in glutamate and aspartate concentrations were found only in the nucleus accumbens, in which a decrease was obtained during both slow-wave sleep and REM sleep compared to waking. A progressive reduction in the release of noradrenaline was observed from waking to REM sleep in both structures. In contrast, dopamine concentrations were higher during waking and REM sleep compared to that during slow-wave sleep. The latter results demonstrate that contrary to the findings of earlier electrophysiologic studies carried out on ventral tegmental area dopaminergic neurons, changes in the release of dopamine in projection areas occur across the sleep-wake cycle. The elevated levels of dopamine during waking and REM sleep in the medial prefrontal cortex and the nucleus accumbens could result from changes during these two states in afferent modulation at the level of cell bodies or at the level of dopaminergic terminals.
301 citations
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TL;DR: In this article, the effect of insulin on obese gene expression was examined in cells of the 3T3-F442A preadipocyte clonal line and the results indicated that the ob gene is expressed in mature fat cells only and support the possibility that insulin is an important regulator of ob gene expression.
300 citations
Authors
Showing all 10355 results
Name | H-index | Papers | Citations |
---|---|---|---|
Robert J. Lefkowitz | 214 | 860 | 147995 |
Johan Auwerx | 158 | 653 | 95779 |
Kenneth M. Yamada | 139 | 446 | 72136 |
Jean-Luc Starck | 133 | 657 | 76224 |
Christophe Benoist | 132 | 470 | 63181 |
Jacques Pouysségur | 125 | 412 | 54656 |
Michel Lazdunski | 125 | 562 | 54650 |
E. A. De Wolf | 124 | 1333 | 83171 |
Leon O. Chua | 122 | 824 | 71612 |
Tomasz Bulik | 121 | 698 | 86211 |
James G. Krueger | 120 | 505 | 46275 |
Austin Smith | 111 | 301 | 63156 |
Peter Fritschel | 108 | 427 | 72722 |
Didier Sornette | 104 | 1295 | 44157 |
François Bondu | 100 | 440 | 69284 |