Institution
University of Nigeria, Nsukka
Education•Nsukka, Nigeria•
About: University of Nigeria, Nsukka is a education organization based out in Nsukka, Nigeria. It is known for research contribution in the topics: Population & Health care. The organization has 10211 authors who have published 13685 publications receiving 138922 citations.
Topics: Population, Health care, Medicine, Public health, Pregnancy
Papers published on a yearly basis
Papers
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TL;DR: In this article, a four-variable central composite experimental design was applied to correlate the adsorption variables (effluent pH, adsorbent dosage, contact time, and ad-sorption temperature).
Abstract: The adsorptive removal of total dissolved solids by activated coal using response surface methodology was investigated. A four-variable central composite experimental design was applied to correlate the adsorption variables (effluent pH, adsorbent dosage, contact time, and adsorption temperature). The adsorption variables were optimized based on the removal of total dissolved solids from fibre cement industry effluent. Three-dimensional surface plots were generated to estimate the effect of the combinations of the independent variables on the adsorption efficiency. The results of the model validation gave experimental yield 96.2%, predicted yield 96.5% obtained at effluent pH 6.27, adsorbent dosage 27.60 mg L−1, contact time 48.00 min, and adsorption temperature of 31.00 °C. The good agreement found between observed and predicted values supports the suitability of the applied model to predict the adsorption treatment.
40 citations
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TL;DR: All the underlying factors and mechanisms involved in Candida pathogenesis are described by evaluating pathogenic determinants of Candida species to improve current understanding of how these factors modulate virulence and consequent infection(s).
Abstract: Candida is the most implicated fungal pathogen in the clinical setting. Several factors play important roles in the pathogenesis of Candida spp. Multiple transcriptional circuits, morphological and phenotypic switching, biofilm formation, tissue damaging extracellular hydrolytic enzymes, metabolic flexibility, genome plasticity, adaptation to environmental pH fluctuation, robust nutrient acquisition system, adherence and invasions (mediated by adhesins and invasins), heat shock proteins (HSPs), cytolytic proteins, escape from phagocytosis, evasion from host immune system, synergistic coaggregation with resident microbiota, resistance to antifungal agents, and the ability to efficiently respond to multiple stresses are some of the major pathogenic determinants of Candida species. The existence of multiple connections, in addition to the interactions and associations among all of these factors, are distinctive features that play important roles in the establishment of Candida infections. This review describes all the underlying factors and mechanisms involved in Candida pathogenesis by evaluating pathogenic determinants of Candida species. It reinforces the already available pool of data on the pathogenesis of Candida species by providing a clear and simplified understanding of the most important factors implicated in the pathogenesis of Candida species. The Candida pathogenesis network, an illustration linking all the major determinants of Candida pathogenesis, is also presented. Taken together, they will further improve our current understanding of how these factors modulate virulence and consequent infection(s). Development of new antifungal drugs and better therapeutic approaches to candidiasis can be achieved in the near future with continuing progress in the understanding of the mechanisms of Candida pathogenesis.
40 citations
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University of London1, LDS Business College2, University of California, Berkeley3, Karolinska Institutet4, University of Gothenburg5, University of Copenhagen6, Uppsala University7, University of Yaoundé8, Makerere University9, University of Nigeria, Nsukka10, Centers for Disease Control and Prevention11, Copenhagen University Hospital12, Statens Serum Institut13
TL;DR: Basic training and resources are essential but insufficient to maximise the potential of rapid diagnostic tests for malaria (mRDTs) in many contexts, and the intensity of supporting interventions required seems likely to reduce.
Abstract: Objectives: The overuse of antimalarial drugs is widespread. Effective methods to improve prescribing practice remain unclear. We evaluated the impact of 10 interventions that introduced rapid diag ...
40 citations
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TL;DR: In this article, the effects of composition on structural, elastic and electronic properties of the materials were evaluated and compared with each other in terms of the sensitivity of the physical and electronics properties to the alloying additions.
40 citations
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TL;DR: All patients who had a diagnosis of invasive oral cancer during this period from 1998 to 2003 were reviewed, and all patients gave no history of alcohol or tobacco misuse, and their conditions should be seen in terms of chronic illnesses, malnutrition, poverty, and ignorance.
Abstract: Cancers of the oral cavity make up 3–4% of all cancers, being in eighth place in men and eleventh in women when the cancer is caused by smoking and alcohol misuse. In this study we recorded all oral cancers in Enugu, eastern Nigeria over the 6-year period from 1998 to 2003. We reviewed all patients who had a diagnosis of invasive oral cancer during this period from notes kept in the Records Department of the University of Nigeria Teaching Hospital (UNTH), Enugu, Nigeria. Carcinoma-in-situ, lymphoma, and leukaemia were not included. All cases were categorised by the site of the tumour and the age and sex of the patient. Eighty one cases of oral cancer were recorded during that period, accounting for 2.7% of all cancers. Forty-eight men and thirty-three women were affected, and the most common site was other sites of the oral cavity (28, 35%), followed by the tongue (24, 30%), floor of the mouth (17, 21%) and finally the lip (12, 15%). They were all advanced at the time of presentation. The patients gave no history of alcohol or tobacco misuse, and their conditions should be seen in terms of chronic illnesses, malnutrition, poverty, and ignorance. We need an urgent awareness campaign, and programmes for the prevention and early detection of oral cancer, in Nigeria.
40 citations
Authors
Showing all 10333 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kamyar Kalantar-Zadeh | 118 | 1025 | 56187 |
Peter J. Houghton | 63 | 228 | 14321 |
Alessandro Piccolo | 62 | 284 | 14332 |
R. W. Guillery | 60 | 106 | 13439 |
Ulrich Klotz | 56 | 213 | 10774 |
Nicholas H. Oberlies | 52 | 262 | 9683 |
Brian Norton | 49 | 322 | 9251 |
Adesola Ogunniyi | 47 | 272 | 11806 |
Obinna Onwujekwe | 43 | 282 | 8960 |
Sanjay Batra | 39 | 329 | 7179 |
Benjamin Uzochukwu | 38 | 163 | 9318 |
Christian N. Madu | 36 | 134 | 5378 |
Jude U. Ohaeri | 36 | 121 | 3088 |
Peter A. Akah | 33 | 164 | 3422 |
Charles E. Chidume | 33 | 153 | 3639 |