University of Saskatchewan

About: University of Saskatchewan is a education organization based out in Saskatoon, Saskatchewan, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 25021 authors who have published 52579 publications receiving 1483049 citations. The organization is also known as: USask.

Course in Parkinson disease subtypes A 39-year clinicopathologic study

Abstract: Background: Individual variations in the course of Lewy body Parkinson disease (PD) are well known. Patients have been classified into different clinical subtypes to identify differences in the course among the subgroups. Several studies indicate that the outcome is more favorable in tremor dominant (TD) cases but others report no difference. A majority of progression studies are based on cross-sectional single point data or short-term clinical observations. The lack of longitudinally followed autopsy-confirmed PD cohort remains a major weakness in the literature. Biochemical studies of brain indicate most pronounced abnormalities in akinetic/rigid (AR) and the least in TD cases. We postulate that PD course in these subtypes is concordant with the biochemical findings. Objective: To compare the course in TD, mixed (MX), and AR subtypes of PD. Methods: Longitudinal clinical follow-up and autopsy studies were performed on 166 patients with PD over 39 years (1968–2006). Patients were classified into TD, AR, and MX based on the entire clinical course. Only the pathologically confirmed PD cases were included. Results: Sixty-six percent of cases had MX, 26% AR, and 8% TD profile. The age at onset was younger ( p p = 0.016) in the TD cases. Dementia was most common in AR ( p = 0.039) and the least common in TD. In general, the course was most favorable in TD, followed by MX and AR subgroups. Conclusion: The three subtypes of Parkinson disease have different courses which are concordant with the differences in brain biochemical abnormalities.

A population-based study of fatigue and sleep difficulties in inflammatory bowel disease.

Abstract: Background: There has been little investigation of fatigue, a common symptom in inflammatory bowel disease (IBD). The aim of this study was to evaluate fatigue more comprehensively, considering relationships with psychological and biological factors simultaneously in a population-based IBD community sample. Methods: Manitoba IBD Cohort Study participants (n = 318; 51% Crohn's disease [CD]) were assessed by survey, interview, and blood sample. Fatigue, sleep quality, daytime drowsiness, stress, psychological distress, and quality of life were measured with validated scales. Hemoglobin (Hg) and C-reactive protein (CRP) levels were also obtained. Differences were tested across disease activity and disease subtype. Results: Elevated CRP was found for 23% of the sample and 12% were anemic; 46% had active disease. Overall, 72% of those with active and 30% with inactive disease reached clinical thresholds for fatigue (Multidimensional Fatigue Inventory; P < 0.001); 77% and 49% of those with active or inactive disease, respectively, experienced poor sleep (P < 0.001). There were few differences between those with CD and ulcerative colitis (UC) on the factors assessed, except for higher CRP levels in CD (mean 8.8 versus 5.3, P < 0.02). Multiple logistic regression analyses found that elevated fatigue was associated with active disease (odds ratio [OR] 4.2, 95% confidence interval [CI] 2.2–7.8), poor sleep quality (OR 4.0, 95% CI 1.9–8.6), and perceived stress (OR 4.2, 95% CI 2.2–8.1), but not with hours of sleep, Hg, or CRP. Conclusions: Fatigue and poor sleep are not only highly prevalent in active disease, but both are still significant concerns for many with inactive disease. Psychological factors are associated with fatigue in IBD in addition to disease and sleep considerations. (Inflamm Bowel Dis 2011;)

A single cell high order scheme for the convection-diffusion equation with variable coefficients

Abstract: On propose un schema de differences finies pour l'equation de convection-diffusion a coefficients variables. Le systeme resultant peut etre resolu par des methodes iteratives

Design of Power and Area Efficient Approximate Multipliers

Abstract: Approximate computing can decrease the design complexity with an increase in performance and power efficiency for error resilient applications. This brief deals with a new design approach for approximation of multipliers. The partial products of the multiplier are altered to introduce varying probability terms. Logic complexity of approximation is varied for the accumulation of altered partial products based on their probability. The proposed approximation is utilized in two variants of 16-bit multipliers. Synthesis results reveal that two proposed multipliers achieve power savings of 72% and 38%, respectively, compared to an exact multiplier. They have better precision when compared to existing approximate multipliers. Mean relative error figures are as low as 7.6% and 0.02% for the proposed approximate multipliers, which are better than the previous works. Performance of the proposed multipliers is evaluated with an image processing application, where one of the proposed models achieves the highest peak signal to noise ratio.