Institution
University of Saskatchewan
Education•Saskatoon, Saskatchewan, Canada•
About: University of Saskatchewan is a education organization based out in Saskatoon, Saskatchewan, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 25021 authors who have published 52579 publications receiving 1483049 citations. The organization is also known as: USask.
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University of Geneva1, Centre national de la recherche scientifique2, University of Saskatchewan3, Natural History Museum4, New York State Department of Health5, Charles University in Prague6, Kaiserslautern University of Technology7, University of Greifswald8, Dalhousie University9, Free University of Berlin10, Academy of Sciences of the Czech Republic11, University of British Columbia12, Sewanee: The University of the South13, Saint Petersburg State University14, Royal Botanic Garden Edinburgh15, University of Cologne16, Uppsala University17, University of New Brunswick18, Halifax19, National Institutes of Health20, University of Giessen21, National Museum of Natural History22
TL;DR: A group of protist experts proposes a two-step DNA barcoding approach, comprising a universal eukaryotic pre-barcode followed by group-specific barcodes, to unveil the hidden biodiversity of microbial Eukaryotes.
Abstract: Animals, plants, and fungi—the three traditional kingdoms of multicellular eukaryotic life—make up almost all of the visible biosphere, and they account for the majority of catalogued species on Earth [1]. The remaining eukaryotes have been assembled for convenience into the protists, a group composed of many diverse lineages, single-celled for the most part, that diverged after Archaea and Bacteria evolved but before plants, animals, or fungi appeared on Earth. Given their single-celled nature, discovering and describing new species has been difficult, and many protistan lineages contain a relatively small number of formally described species (Figure 1A), despite the critical importance of several groups as pathogens, environmental quality indicators, and markers of past environmental changes. It would seem natural to apply molecular techniques such as DNA barcoding to the taxonomy of protists to compensate for the lack of diagnostic morphological features, but this has been hampered by the extreme diversity within the group. The genetic divergence observed between and within major protistan groups greatly exceeds that found in each of the three multicellular kingdoms. No single set of molecular markers has been identified that will work in all lineages, but an international working group is now close to a solution. A universal DNA barcode for protists coupled with group-specific barcodes will enable an explosion of taxonomic research that will catalyze diverse applications.
458 citations
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TL;DR: Depression (as measured by the BDI) in PD, “satisfaction with the explanation of the condition at diagnosis” and “current feelings of optimism” have a significant impact on HRQL, first step towards developing management guidelines that truly influence the HRQL of patients with PD.
Abstract: Current management guidelines for the treatment of patients with Parkinson's disease (PD) are limited due to the lack of knowledge of factors that influence health‐related quality of life (HRQL). To assess the HRQL of people with PD, and to systematically identify and evaluate those factors (other than disease severity and medication, which could have an impact), we undertook a cross‐sectional, randomized selection, multicenter international survey of patients with PD, caregivers, and clinicians. Face‐to‐face interviews were conducted with subjects in six countries. Disease severity, medication, and other factors hypothesized to influence HRQL were assessed using a combination of specially developed questionnaires and validated instruments including the Parkinson's Disease Questionnaire‐39 (HRQL), Hoehn and Yahr Stage (disease severity), and Beck's Depression Inventory (BDI; depression). Multiple linear regression models were used to demonstrate whether the factors investigated contribute significantly to HRQL. The results obtained indicated that Hoehn and Yahr stage and medication explained only 17.3% of the variability in HRQL of patients with PD, although both were significant (R2 = 0.173, P < 0.05). Other factors increased the explanatory power to adjusted R2 = 0.597, with BDI being the most significant predictor of variability in HRQL (adjusted R2 = 0.582; P < 0.001), followed by “Satisfaction with the explanation of the condition at diagnosis” and “Current feelings of optimism” (both P < 0.05). These factors, in addition to disease severity and medication, explain 59.7% of the variability in HRQL across the population. In conclusion, depression (as measured by the BDI) in PD, “satisfaction with the explanation of the condition at diagnosis” and “current feelings of optimism” have a significant impact on HRQL. The completion of this initial analysis is the first step towards developing management guidelines that truly influence the HRQL of patients with PD. © 2001 Movement Disorder Society.
458 citations
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TL;DR: Intestinal viscosity, which rose as digesta passed from the proximal to distal small intestine, fell with pentosanase addition and decreasing rye concentration, and correlated positively with reduced weight gain and FCE.
Abstract: The effect of dietary rye (0, 200, 400 and 600 g/kg substituting for wheat) and pentosanase concentration (0, 1, 2, 4, 8, 16 g/kg) on weight gain, molecular weight distribution of soluble carbohydrates in the intestinal lumen and lumenal viscosity in broiler chicks was investigated. A 4 x 6 factorial design was used with four replicates per treatment and six birds per replicate pen. Diets were fed from 1 to 19 d of age, at which time body weight, food intake and intestinal viscosity and molecular weight distribution of carbohydrate complexes in proximal and distal gut sections were determined. Weight gain and food conversion efficiency (FCE) improved with increasing pentosanase and decreasing rye concentration. Intestinal viscosity, which rose as digesta passed from the proximal to distal small intestine, fell with pentosanase addition and decreasing rye concentration. Intestinal viscosity, which correlated positively with reduced weight gain and FCE, was in turn correlated with the lumenal concentration of soluble high-molecular-weight carbohydrates (HMC, greater than 500 kDa), which constituted less than 15% of the total lumenal carbohydrate concentration. The arabinose and xylose content of the HMC increased with increasing rye concentration, suggesting that HMC composition in addition to concentration may determine intestinal viscosity. The results indicate that pentosanase isolated from rye by extraction methods may not be representative of those released by digestion.
458 citations
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McMaster University1, University of Pennsylvania2, University of Calgary3, Libin Cardiovascular Institute of Alberta4, Dalhousie University5, University of Alberta6, Alexandra Hospital7, Laval University8, University of Ottawa9, Concordia University10, Ottawa Hospital11, University of British Columbia12, Heart and Stroke Foundation of Canada13, Florida International University14, Queen's University15, University of Toronto16, Alberta Health Services17, Centre for Addiction and Mental Health18, University Health Network19, University of Minnesota20, York University21, Université de Sherbrooke22, Centre Hospitalier Universitaire de Sherbrooke23, Simon Fraser University24, Vancouver Island Health Authority25, Foothills Medical Centre26, University of Saskatchewan27, Population Health Research Institute28, St. Michael's Hospital29, St. John's University30, Memorial University of Newfoundland31
TL;DR: Obesity is a complex chronic disease in which abnormal or excess body fat (adiposity) impairs health, increases the risk of long-term medical complications and reduces lifespan.
Abstract: KEY POINTS
Obesity is a complex chronic disease in which abnormal or excess body fat (adiposity) impairs health, increases the risk of long-term medical complications and reduces lifespan.[1][1] Epidemiologic studies define obesity using the body mass index (BMI; weight/height2), which can stratify
457 citations
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TL;DR: In this article, the authors show that groundwater extraction is the main driver of saltwater intrusion in the United States, highlighting the importance of sustainable water management and highlighting the need for sustainable management.
Abstract: There are concerns that sea-level rise resulting from climate change could lead to saltwater intrusion into coastal aquifers. However, a study shows that groundwater extraction is the main driver of saltwater intrusion in the United States, highlighting the importance of sustainable water management.
456 citations
Authors
Showing all 25277 results
Name | H-index | Papers | Citations |
---|---|---|---|
Tomas Hökfelt | 158 | 1033 | 95979 |
Frederick Wolfe | 119 | 417 | 101272 |
Christopher G. Goetz | 116 | 651 | 59510 |
John P. Giesy | 114 | 1162 | 62790 |
Helmut Kettenmann | 104 | 380 | 40211 |
Paul M. O'Byrne | 104 | 605 | 56520 |
Susan S. Taylor | 104 | 518 | 42108 |
Keith A. Hobson | 103 | 653 | 41300 |
Mark S. Tremblay | 100 | 541 | 43843 |
James F. Fries | 100 | 369 | 83589 |
Gordon McKay | 97 | 661 | 61390 |
Jonathan D. Adachi | 96 | 589 | 31641 |
Wenjun Zhang | 96 | 976 | 38530 |
William C. Dement | 96 | 340 | 43014 |
Chris Ryan | 95 | 971 | 34388 |