Institution
University of Warsaw
Education•Warsaw, Poland•
About: University of Warsaw is a education organization based out in Warsaw, Poland. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 20832 authors who have published 56617 publications receiving 1185084 citations. The organization is also known as: Uniwersytet Warszawski & Warsaw University.
Papers published on a yearly basis
Papers
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TL;DR: This study revealed the existence of a DSB-induced monoubiquitination-to-acetylation switch on histone H2B lysine 120, likely mediated by the SAGA complex, as well as higher-order signaling at HR-repaired DSBs whereby hist one H1 is evicted while ubiquitin and 53BP1 accumulate over the entire γH2AX domains.
202 citations
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TL;DR: In this paper, a comparison of the relative yields of upsilon resonances in the mu(+) mu(-) decay channel in PbPb and pp collisions at a centre-of-mass energy per nucleon pair of 2.76 TeV, is performed with data collected with the CMS detector at the LHC.
Abstract: A comparison of the relative yields of Upsilon resonances in the mu(+) mu(-) decay channel in PbPb and pp collisions at a centre-of-mass energy per nucleon pair of 2.76 TeV, is performed with data collected with the CMS detector at the LHC. Using muons of transverse momentum above 4 GeV/c and pseudorapidity below 2.4, the double ratio of the Upsilon(2S) and Upsilon(3S) excited states to the Upsilon(1S) ground state in PbPb and pp collisions,(Upsilon(2S+3S)/Upsilon(1S)[PbPb])/(Upsilon(2S+3S)/Upsilon(1S)[pp]), is found to be 0.31 - 0.15 + 0.19 (stat.) +/- 0.03 (syst.). The probability to obtain the measured value, or lower, if the true double ratio is unity, has been calculated to be less than 1%.
202 citations
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TL;DR: In this article, the first measurement of the F 2 structure function in neutral-current, deep inelastic scattering using the ZEUS detector at HERA, the ep colliding beam facility at DESY, was presented.
202 citations
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TL;DR: The role of arginases produced by myeloid cells in regulating various populations of immune cells is described, molecular mechanisms of immunoregulatory processes involving L-arginine metabolism are discussed and therapeutic approaches to mitigate the negative effects ofArginases on antitumor immune response are outlined.
Abstract: Amino acid metabolism is a critical regulator of the immune response, and its modulating becomes a promising approach in various forms of immunotherapy. Insufficient concentrations of essential amino acids restrict T-cells activation and proliferation. However, only arginases, that degrade L-arginine, as well as enzymes that hydrolyze L-tryptophan are substantially increased in cancer. Two arginase isoforms, ARG1 and ARG2, have been found to be present in tumors and their increased activity usually correlates with more advanced disease and worse clinical prognosis. Nearly all types of myeloid cells were reported to produce arginases and the increased numbers of various populations of myeloid-derived suppressor cells and macrophages correlate with inferior clinical outcomes of cancer patients. Here, we describe the role of arginases produced by myeloid cells in regulating various populations of immune cells, discuss molecular mechanisms of immunoregulatory processes involving L-arginine metabolism and outline therapeutic approaches to mitigate the negative effects of arginases on antitumor immune response. Development of potent arginase inhibitors, with improved pharmacokinetic properties, may lead to the elaboration of novel therapeutic strategies based on targeting immunoregulatory pathways controlled by L-arginine degradation.
201 citations
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TL;DR: Reduced computer modeling of proteins now has a history of about 30 years, and more complex models now enable modeling of real proteins on the level of low to moderate resolution, allowing us to address more detailed questions.
201 citations
Authors
Showing all 21191 results
Name | H-index | Papers | Citations |
---|---|---|---|
Alexander Malakhov | 139 | 1486 | 99556 |
Emmanuelle Perez | 138 | 1550 | 99016 |
Piotr Zalewski | 135 | 1388 | 89976 |
Krzysztof Doroba | 133 | 1440 | 89029 |
Hector F. DeLuca | 133 | 1303 | 69395 |
Krzysztof M. Gorski | 132 | 380 | 105912 |
Igor Golutvin | 131 | 1282 | 88559 |
Jan Krolikowski | 131 | 1289 | 83994 |
Michal Szleper | 130 | 1238 | 82036 |
Anatoli Zarubin | 129 | 1204 | 86435 |
Malgorzata Kazana | 129 | 1175 | 81106 |
Artur Kalinowski | 129 | 1162 | 81906 |
Predrag Milenovic | 129 | 1185 | 81144 |
Marcin Konecki | 128 | 1178 | 79392 |
Karol Bunkowski | 128 | 1192 | 79455 |