Showing papers by "University of Warsaw published in 2009"

Biopython: freely available Python tools for computational molecular biology and bioinformatics

Abstract: The Biopython project is a mature open source international collaboration of volunteer developers, providing Python libraries for a wide range of bioinformatics problems. Biopython includes modules for reading and writing different sequence. le formats and multiple sequence alignments, dealing with 3D macromolecular structures, interacting with common tools such as BLAST, ClustalW and EMBOSS, accessing key online databases, as well as providing numerical methods for statistical learning.

National differences in gender–science stereotypes predict national sex differences in science and math achievement

Abstract: About 70% of more than half a million Implicit Association Tests completed by citizens of 34 countries revealed expected implicit stereotypes associating science with males more than with females. We discovered that nation-level implicit stereotypes predicted nation-level sex differences in 8th-grade science and mathematics achievement. Self-reported stereotypes did not provide additional predictive validity of the achievement gap. We suggest that implicit stereotypes and sex differences in science participation and performance are mutually reinforcing, contributing to the persistent gender gap in science engagement.

Optimal quantum phase estimation.

Abstract: By using a systematic optimization approach, we determine quantum states of light with definite photon number leading to the best possible precision in optical two-mode interferometry. Our treatment takes into account the experimentally relevant situation of photon losses. Our results thus reveal the benchmark for precision in optical interferometry. Although this boundary is generally worse than the Heisenberg limit, we show that the obtained precision beats the standard quantum limit, thus leading to a significant improvement compared to classical interferometers. We furthermore discuss alternative states and strategies to the optimized states which are easier to generate at the cost of only slightly lower precision.

The Moho depth map of the European Plate

Abstract: SUMMARY The European Plate has a 4.5 Gy long and complex tectonic history. This is reflected in the present-day large-scale crustal structures. A new digital Moho depth map is compiled from more than 250 data sets of individual seismic profiles, 3-D models obtained by body and surface waves, receiver function results and maps of seismic and/or gravity data compilations. We have compiled the first digital, high-resolution map of the Moho depth for the whole European Plate, extending from the mid-Atlantic ridge in the west to the Ural Mountains in the east, and from the Mediterranean Sea in the south to the Barents Sea and Spitsbergen in the Arctic in the north. In general, three large domains within the European Plate crust are visible. The oldest Archean and Proterozoic crust has a thickness of 40–60 km, the continental Variscan and Alpine crust has a thickness of 20–40 km, and the youngest oceanic Atlantic crust has a thickness of 10–20 km.

General overview: European Integrated project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) - integrating aerosol research from nano to global scales

Abstract: In this paper we describe and summarize the main achievements of the European Aerosol Cloud Climate and Air Quality Interactions project (EUCAARI). EUCAARI started on 1 January 2007 and ended on 31 December 2010 leaving a rich legacy including: (a) a comprehensive database with a year of observations of the physical, chemical and optical properties of aerosol particles over Europe, (b) comprehensive aerosol measurements in four developing countries, (c) a database of airborne measurements of aerosols and clouds over Europe during May 2008, (d) comprehensive modeling tools to study aerosol processes fron nano to global scale and their effects on climate and air quality. In addition a new Pan-European aerosol emissions inventory was developed and evaluated, a new cluster spectrometer was built and tested in the field and several new aerosol parameterizations and computations modules for chemical transport and global climate models were developed and evaluated. These achievements and related studies have substantially improved our understanding and reduced the uncertainties of aerosol radiative forcing and air quality-climate interactions. The EUCAARI results can be utilized in European and global environmental policy to assess the aerosol impacts and the corresponding abatement strategies.

Collective narcissism and its social consequences.

Abstract: This article introduces the concept of collective narcissism--an emotional investment in an unrealistic belief about the in group's greatness--aiming to explain how feelings about an ingroup shape a tendency to aggress against outgroups. The results of 5 studies indicate that collective, but not individual, narcissism predicts intergroup aggressiveness. Collective narcissism is related to high private and low public collective self-esteem and low implicit group esteem. It predicts perceived threat from outgroups, unwillingness to forgive outgroups, preference for military aggression over and above social dominance orientation, right-wing authoritarianism, and blind patriotism. The relationship between collective narcissism and aggressiveness is mediated by perceived threat from outgroups and perceived insult to the ingroup. In sum, the results indicate that collective narcissism is a form of high but ambivalent group esteem related to sensitivity to threats to the ingroup's image and retaliatory aggression.

Nucleosomes are well positioned in exons and carry characteristic histone modifications

Abstract: The genomes of higher organisms are packaged in nucleosomes with functional histone modifications. Until now, genome-wide nucleosome and histone modification studies have focused on transcription start sites (TSSs) where nucleosomes in RNA polymerase II (RNAPII) occupied genes are well positioned and have histone modifications that are characteristic of expression status. Using public data, we here show that there is a higher nucleosome-positioning signal in internal human exons and that this positioning is independent of expression. We observed a similarly strong nucleosome-positioning signal in internal exons of Caenorhabditis elegans. Among the 38 histone modifications analyzed in man, H3K36me3, H3K79me1, H2BK5me1, H3K27me1, H3K27me2, and H3K27me3 had evidently higher signals in internal exons than in the following introns and were clearly related to exon expression. These observations are suggestive of roles in splicing. Thus, exons are not only characterized by their coding capacity, but also by their nucleosome organization, which seems evolutionarily conserved since it is present in both primates and nematodes.

Increasing Evidence for Hemispherical Power Asymmetry in the Five-Year WMAP Data

Abstract: Motivated by the recent results of Hansen et al. concerning a noticeable hemispherical power asymmetry in the Wilkinson Microwave Anisotropy Probe (WMAP) data on small angular scales, we revisit the dipole-modulated signal model introduced by Gordon et al.. This model assumes that the true cosmic microwave background signal consists of a Gaussian isotropic random field modulated by a dipole, and is characterized by an overall modulation amplitude, A, and a preferred direction, ṕ. Previous analyses of this model have been restricted to very low resolution (i.e., 3°.6 pixels, a smoothing scale of 9° FWHM, and l ≾40) due to computational cost. In this paper, we double the angular resolution (i.e., 1°.8 pixels and 4°.5 FWHM smoothing scale), and compute the full corresponding posterior distribution for the five-year WMAP data. The results from our analysis are the following: the best-fit modulation amplitude for l ≤ 64 and the ILC data with the WMAP KQ85 sky cut is A = 0.072 ± 0.022, nonzero at 3.3σ, and the preferred direction points toward Galactic coordinates (l, b) = (224°, – 22°) ± 24°. The corresponding results for l ≾ 40 from earlier analyses were A = 0.11 ± 0.04 and (l, b) = (225°, – 27°). The statistical significance of a nonzero amplitude thus increases from 2.8σ to 3.3σ when increasing l_(max) from 40 to 64, and all results are consistent to within 1σ. Similarly, the Bayesian log-evidence difference with respect to the isotropic model increases from Δln E = 1.8 to Δln E = 2.6, ranking as "strong evidence" on the Jeffreys' scale. The raw best-fit log-likelihood difference increases from Δln L=6.1 to Δln L=7.3. Similar, and often slightly stronger, results are found for other data combinations. Thus, we find that the evidence for a dipole power distribution in the WMAP data increases with l in the five-year WMAP data set, in agreement with the reports of Hansen et al.

Quantifying Quasar Variability As Part of a General Approach To Classifying Continuously Varying Sources

Abstract: Robust fast methods to classify variable light curves in large sky surveys are becoming increasingly important. While it is relatively straightforward to identify common periodic stars and particular transient events (supernovae, novae, microlensing), there is no equivalent for non-periodic continuously varying sources (quasars, aperiodic stellar variability). In this paper we present a fast method for modeling and classifying such sources. We demonstrate the method using ~ 86,000 variable sources from the OGLE-II survey of the LMC and ~ 2,700 mid-IR selected quasar candidates from the OGLE-III survey of the LMC and SMC. We discuss the location of common variability classes in the parameter space of the model. In particular we show that quasars occupy a distinct region of variability space, providing a simple quantitative approach to the variability selection of quasars.

Extragalactic chemical abundances: do h ii regions and young stars tell the same story? the case of the spiral galaxy ngc 300*

Abstract: We have obtained new spectrophotometric data for 28 H II regions in the spiral galaxy NGC 300, a member of the nearby Sculptor Group. The detection of several auroral lines, including [O III] λ4363, [S III] λ6312, and [N II] λ5755, has allowed us to measure electron temperatures and direct chemical abundances for the whole sample. We determine for the first time in this galaxy a radial gas-phase oxygen abundance gradient based solely on auroral lines, and obtain the following least-square solution: 12 + log(O/H) = 8.57(±0.02) – 0.41(±0.03)R/R 25, where the galactocentric distance is expressed in terms of the isophotal radius R 25. The characteristic oxygen abundance, measured at 0.4 × R 25, is 12 + log(O/H) = 8.41. The gradient corresponds to –0.077 ± 0.006 dex kpc–1, and agrees very well with the galactocentric trend in metallicity obtained for 29 B and A supergiants in the same galaxy, –0.081 ± 0.011 dex kpc–1. The intercept of the regression for the nebular data virtually coincides with the intercept obtained from the stellar data, which is 8.59(±0.05). This allows little room for depletion of nebular oxygen onto dust grains, although in this kind of comparison we are somewhat limited by systematic uncertainties, such as those related to the atomic parameters used to derive the chemical compositions. We discuss the implications of our result with regard to strong-line abundance indicators commonly used to estimate the chemical compositions of star-forming galaxies, such as R 23. By applying a few popular calibrations of these indices based on grids of photoionization models on the NGC 300 H II region fluxes, we find metallicities that are higher by 0.3 dex (a factor of 2) or more relative to our nebular (Te based) and stellar ones. We detect Wolf-Rayet stellar emission features in ~1/3 of our H II region spectra, and find that in one of the nebulae hosting these hot stars the ionizing field has a particularly hard spectrum, as gauged by the "softness" parameter η = (O+/O++)/(S+/S++). We suggest that this is related to the presence of an early WN star. By considering a larger sample of extragalactic H II regions we confirm, using direct abundance measurements, previous findings of a metallicity dependence of η, in the sense that softer stellar continua are found at high metallicity.

Analysis of phenolic acids and flavonoids in honey

Abstract: Honey is rich in phenolic acids and flavonoids, which exhibit a wide range of biological effects and act as natural antioxidants. The analysis of polyphenols has been regarded as a very promising way of studying floral and geographical origins of honeys. This review surveys recent literature on determination of these active compounds in honey. The analytical procedure to determine individual phenolic compounds involves their extraction from the sample matrix, analytical separation and quantification. We pay particular attention to sample pre-treatment and separation techniques (e.g., high-performance liquid chromatography and electrophoresis).

Acidity of Hydroxyl Groups: An Overlooked Influence on Antiradical Properties of Flavonoids

Abstract: The reactions of 10 flavonoids with 2,2-diphenyl-1-picrylhydrazyl radical (dpph(*)) carried out in alcohols always occur significantly faster than in acidified alcohols or in dioxane. These fast kinetics benefit from the contribution of the electron transfer from a flavonoid anion to a radical, a mechanism known as Sequential Proton-Loss Electron-Transfer (SPLET), which adds to the kinetics of single-step Hydrogen Atom Transfer (HAT)/Proton Coupled Electron Transfer (PCET) processes (see Acc. Chem. Res. 2007, 40 , 222.). The domination of SPLET over HAT/PCET in case of a flavonoid reacting with electron-deficient radicals such as peroxyls or dpph(*) in polar solvents explains the enhancement of antioxidant activity of 3-hydroxyflavone. It also elucidates the great acceleration in the reactions of dpph(*) with quercetin, morin, galangin, and 7,8-dihydroxyflavone. The analysis of structure-acidity and structure-activity relationships for 10 flavonoids clearly indicates that hydroxyl group at position 7 is the most acidic site. Thus, in polar solvents this group can participate in radical reaction via SPLET. In nonpolar solvents the most active site in quercetin (a flavonoid antioxidant commonly found in plants) is 3',4'-dihydroxyl moiety and HAT/PCET occurs. However, in ionization-supporting solvents an anion formed at position 7 is responsible for very fast kinetics of quercetin/dpph(*) reaction because both mechanisms participate: HAT (from catechol moiety in ring B) and SPLET (from ionized 7-hydroxyl in ring A). Because of conjugation of rings A, B, and C the final structure of the formed quercetin radical (or quercetin anion radical) is the same for the SPLET and HAT/PCET mechanisms.

Theory of the topological anderson insulator.

Abstract: We present an effective medium theory that explains the disorder-induced transition into a phase of quantized conductance, discovered in computer simulations of HgTe quantum wells. It is the combination of a random potential and quadratic corrections proportional to p2 sigma(z) to the Dirac Hamiltonian that can drive an ordinary band insulator into a topological insulator (having an inverted band gap). We calculate the location of the phase boundary at weak disorder and show that it corresponds to the crossing of a band edge rather than a mobility edge. Our mechanism for the formation of a topological Anderson insulator is generic, and would apply as well to three-dimensional semiconductors with strong spin-orbit coupling.

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

Abstract: Selenium is linked to male fertility. Glutathione peroxidase 4 (GPx4), first described as an antioxidant enzyme, is the predominant selenoenzyme in testis and has been suspected of being vital for spermatogenesis. Cytosolic, mitochondrial, and nuclear isoforms are all encoded by the same gene. While disruption of entire GPx4 causes early embryonic lethality in mice, inactivation of nuclear GPx4 does not impair embryonic development or fertility. Here, we show that deletion of mitochondrial GPx4 (mGPx4) allows both normal embryogenesis and postnatal development, but causes male infertility. Infertility was associated with impaired sperm quality and severe structural abnormalities in the midpiece of spermatozoa. Knockout sperm display higher protein thiol content and recapitulate features typical of severe selenodeficiency. Interestingly, male infertility induced by mGPx4 depletion could be bypassed by intracytoplasmic sperm injection. We also show for the first time that mGPx4 is the prevailing GPx4 product in male germ cells and that mGPx4 disruption has no effect on proliferation or apoptosis of germinal or somatic tissue. Our study finally establishes that mitochondrial GPx4 confers the vital role of selenium in mammalian male fertility and identifies cytosolic GPx4 as the only GPx4 isoform being essential for embryonic development and apoptosis regulation.

Fundamental processes of quantum electrodynamics in laser fields of relativistic power

Abstract: In this review we summarize our progress in the investigation of fundamental processes of quantum electrodynamics in laser fields of relativistic power in view of the more recent experimental progress in the generation of laser field intensities, yielding ponderomotive energy shifts Up of the order of magnitude mc2 and beyond. In particular, the generation of electron–positron pairs during the collision of laser pulses with ions or protons appears to become feasible.

Detection of Gamma Rays from a Starburst Galaxy

Abstract: Starburst galaxies exhibit in their central regions a highly increased rate of supernovae, the remnants of which are thought to accelerate energetic cosmic rays up to energies of ~ 10^15 eV. We report the detection of gamma rays -- tracers of such cosmic rays -- from the starburst galaxy NGC 253 using the H.E.S.S. array of imaging atmospheric Cherenkov telescopes. The gamma-ray flux above 220 GeV is F = (5.5 +/- 1.0stat +/- 2.8sys) x 10^-13 ph. s-1 cm-2, implying a cosmic-ray density about three orders of magnitude larger than that in the center of the Milky Way. The fraction of cosmic-ray energy channeled into gamma rays in this starburst environment is 5 times larger than that in our Galaxy.

Quantum phase estimation with lossy interferometers

Abstract: We give a detailed discussion of optimal quantum states for optical two-mode interferometry in the presence of photon losses. We derive analytical formulae for the precision of phase estimation obtainable using quantum states of light with a definite photon number and prove that maximization of the precision is a convex optimization problem. The corresponding optimal precision, i.e., the lowest possible uncertainty, is shown to beat the standard quantum limit thus outperforming classical interferometry. Furthermore, we discuss more general inputs: states with indefinite photon number and states with photons distributed between distinguishable time bins. We prove that neither of these is helpful in improving phase estimation precision.

Field Effect Transistors for Terahertz Detection: Physics and First Imaging Applications

Abstract: Resonant frequencies of the two-dimensional plasma in FETs increase with the reduction of the channel dimensions and can reach the THz range for sub-micron gate lengths. Nonlinear properties of the electron plasma in the transistor channel can be used for the detection and mixing of THz frequencies. At cryogenic temperatures resonant and gate voltage tunable detection related to plasma waves resonances is observed. At room temperature, when plasma oscillations are overdamped, the FET can operate as an efficient broadband THz detector. We present the main theoretical and experimental results on THz detection by FETs in the context of their possible application for THz imaging.

When Left Is Right: Party Ideology and Policy in Post-Communist Europe

Abstract: According to the classic partisan theory of spending, leftist parties are expected to increase government spending, and rightist parties are expected to decrease it. We argue that this relationship does not hold in post-Communist countries, where in the context of dual transition to democracy and to a market economy, leftist parties have had stronger incentives and better opportunities to enact tighter budgets, whereas rightist parties were compelled to spend more in order to alleviate economic hardships. We illustrate this theoretical argument with case studies from Hungary and Poland. We then test and find support for our theory by considering the influence of cabinet ideology on total, health, and education spending in thirteen post-Communist democracies from 1989 to 2004. We explore various alternative explanations and provide further narratives to support our causal argument.

Analysis of Neurophysiological Reactions to Advertising Stimuli by Means of EEG and Galvanic Skin Response Measures

Abstract: This article demonstrates how marketing may benefit from neurophysiology. The authors discuss a particular research case concerning the analysis of a skin care product advertisement. Pretests of 2 versions of this TV ad revealed that, although the versions were almost identical, each of them generated significantly different impact. Their influence was assessed using both cognitive measures (benefits and key benefits recall) and behavioral measures (shelf test). The only difference between these 2 versions of the ad was in a single scene that contained a particular gesture by a female model. Of note, the gesture appeared to enhance the effectiveness of the ad. The authors tested whether neurophysiological measures can capture differences in consumer reactions to slightly different marketing stimuli. Indeed, by using electroencephalography and electromyography and by monitoring skin conductance, the authors were able to register significant differences in neurophysiological reactions to an altered scene, even though the difference was not consciously seen. The authors believe that neurophysiological measures soon will be widely acknowledged and used as a complimentary method in classical marketing research.

Quantum Goos-Hänchen effect in graphene.

Abstract: The Goos-Hanchen (GH) effect is an interference effect on total internal reflection at an interface, resulting in a shift sigma of the reflected beam along the interface. We show that the GH effect at a p-n interface in graphene depends on the pseudospin (sublattice) degree of freedom of the massless Dirac fermions, and find a sign change of sigma at angle of incidence alpha=arcsin sqrt[sinalpha{c}] determined by the critical angle alpha{c} for total reflection. In an n-doped channel with p-doped boundaries the GH effect doubles the degeneracy of the lowest propagating mode, introducing a twofold degeneracy on top of the usual spin and valley degeneracies. This can be observed as a stepwise increase by 8e;{2}/h of the conductance with increasing channel width.

Measurement of D ± and D 0 production in deep inelastic scattering using a lifetime tag at HERA

Abstract: The production of D-+/-- and D-0-mesons has been measured with the ZEUS detector at HERA using an integrated luminosity of 133.6 pb(-1). The measurements cover the kinematic range 5 < Q(2) < 1000 GeV2, 0.02 < y < 0.7, 1.5 < p(T)(D) < 15 GeV and |eta(D)| < 1.6. Combinatorial background to the D-meson signals is reduced by using the ZEUS microvertex detector to reconstruct displaced secondary vertices. Production cross sections are compared with the predictions of next-to-leading-order QCD, which is found to describe the data well. Measurements are extrapolated to the full kinematic phase space in order to obtain the open-charm contribution, F-2(c (c) over bar), to the proton structure function, F-2.

OGLE-2005-BLG-071Lb, THE MOST MASSIVE M DWARF PLANETARY COMPANION?

Abstract: We combine all available information to constrain the nature of OGLE-2005-BLG-071Lb, the second planet discovered by microlensing and the first in a high-magnification event. These include photometric and astrometric measurements from the Hubble Space Telescope, as well as constraints from higher order effects extracted from the ground-based light curve, such as microlens parallax, planetary orbital motion, and finite-source effects. Our primary analysis leads to the conclusion that the host of Jovian planet OGLE-2005-BLG-071Lb is an M dwarf in the foreground disk with mass M = 0.46 ± 0.04 Msun, distance Dl = 3.2 ± 0.4 kpc, and thick-disk kinematics vLSR ~ 103 km s‑1. From the best-fit model, the planet has mass Mp = 3.8 ± 0.4 MJupiter, lies at a projected separation r⊥ = 3.6 ± 0.2AU from its host, and so has an equilibrium temperature of T ~ 55 K, that is, similar to Neptune. A degenerate model gives similar planetary mass Mp = 3.4 ± 0.4 MJupiter with a smaller projected separation, r⊥ = 2.1 ± 0.1AU, and higher equilibrium temperature, T ~ 71 K. These results from the primary analysis suggest that OGLE-2005-BLG-071Lb is likely to be the most massive planet yet discovered that is hosted by an M dwarf. However, the formation of such high-mass planetary companions in the outer regions of M dwarf planetary systems is predicted to be unlikely within the core-accretion scenario. There are a number of caveats to this primary analysis, which assumes (based on real but limited evidence) that the unlensed light coincident with the source is actually due to the lens, that is, the planetary host. However, these caveats could mostly be resolved by a single astrometric measurement a few years after the event.

Luminosities and mass-loss rates of SMC and LMC AGB stars and red supergiants

Abstract: Context. Mass loss is one of the fundamental properties of Asymptotic Giant Branch (AGB) stars, and through the enrichment of the interstellar medium, AGB stars are key players in the life cycle of dust and gas in the universe. However, a quantitative understanding of the mass-loss process is still largely lacking, particularly its dependence on metallicity. Aims. To investigate the relation between mass loss, luminosity and pulsation period for a large sample of evolved stars in the Small and Large Magellanic Cloud.Methods. Dust radiative transfer models are presented for 101 carbon stars and 86 oxygen-rich evolved stars in the Magellanic Clouds for which 5–35 μ m Spitzer IRS spectra are available. The spectra are complemented with available optical and infrared photometry to construct the spectral energy distribution. A minimisation procedure is used to fit luminosity, mass-loss rate and dust temperature at the inner radius. Different effective temperatures and dust content are also considered. Periods from the literature and from new OGLE-III data are compiled and derived.Results. We derive (dust) mass-loss rates and luminosities for the entire sample. Based on luminosities, periods and amplitudes and colours, the O-rich stars are classified as foreground objects, AGB stars and Red Super Giants. For the O-rich stars silicates based on laboratory optical constants are compared to “astronomical silicates”. Overall, the grain type by Volk & Kwok (1988, ApJ, 331, 435) fits the data best. However, the fit based on laboratory optical constants for the grains can be improved by abandoning the small-particle limit. The influence of grain size, core-mantle grains and porosity are explored. A computationally convenient method that seems to describe the observed properties in the 10 μ m window are a distribution of hollow spheres with a large vacuum fraction (typically 70%), and grain size of about 1 μ m. Relations between mass-loss rates and luminosity and pulsation period are presented and compared to the predictions of evolutionary models, those by Vassiliadis & Wood (1993, ApJ, 413, 641) and their adopted mass-loss recipe, and those based on a Reimers mass-loss law with a scaling of a factor of five. The Vassiliadis & Wood models describe the data better, although there are also some deficiencies, in particular to the maximum adopted mass-loss rate. The derived mass-loss rates are compared to predictions by dynamical wind models and appear consistent with them at a level of a factor 2–4. A better understanding requires the determination of the expansion velocity from future observations from ALMA. The OGLE-III data reveal an O-rich star in the SMC with a period of 1749 days. Its absolute magnitude of makes it a good candidate for a super-AGB star.

Power asymmetry in cosmic microwave background fluctuations from full sky to sub-degree scales: Is the universe isotropic?

Abstract: We repeat and extend the analysis of Eriksen et al. and Hansen et al., testing the isotropy of the cosmic microwave background fluctuations. We find that the hemispherical power asymmetry previously reported for the largest scales l = 2-40 extends to much smaller scales. In fact, for the full multipole range l = 2-600, significantly more power is found in the hemisphere centered at (θ = 107° ± 10°, ∅ = 226° ± 10°) in galactic co-latitude and longitude than in the opposite hemisphere, consistent with the previously detected direction of asymmetry for l = 2-40. We adopt a model selection test where the direction and amplitude of asymmetry, as well as the multipole range, are free parameters. A model with an asymmetric distribution of power for l = 2-600 is found to be preferred over the isotropic model at the 0.4% significance level, taking into account the additional parameters required to describe it. A similar direction of asymmetry is found independently in all six subranges of 100 multipoles between l = 2-600. None of our 9800 isotropic simulated maps show a similarly consistent direction of asymmetry over such a large multipole range. No known systematic effects or foregrounds are found to be able to explain the asymmetry.

Binary planetary nebulae nuclei towards the Galactic bulge - I. Sample discovery, period distribution, and binary fraction

Abstract: Binarity has been hypothesised to play an important, if not ubiquitous, role in the formation of planetary nebulae (PNe). Yet there remains a severe paucity of known binary central stars required to test the binary hypothesis and to place strong constraints on the physics of the common-envelope (CE) phase of binary stellar evolution. Large photometric surveys offer an unrivalled opportunity to efficiently discover many binary central stars. We have combined photometry from the OGLE microlensing survey with the largest sample of PNe towards the Galactic bulge to systematically search for new binaries. A total of 21 periodic binaries were found thereby more than doubling the known sample. The orbital period distribution was found to be best described by CE population synthesis models when no correlation between primary and secondary masses is assumed for the initial mass ratio distribution. A comparison with post-CE white dwarf binaries indicates both distributions are representative of the true post-CE period distribution with most binaries exhibiting periods less than one day. A close binary fraction of 12-21% is derived and is the first robust and independent validation of the previous 10-15% estimate. This suggests that binarity is not a precondition for the formation of PNe and that close binaries do not play a dominant role in the shaping of nebular morphologies. Systematic effects and biases of the survey are discussed with implications for future photometric surveys.

Conformational selection and induced fit mechanism underlie specificity in noncovalent interactions with ubiquitin

Abstract: Noncovalent binding interactions between proteins are the central physicochemical phenomenon underlying biological signaling and functional control on the molecular level. Here, we perform an extensive structural analysis of a large set of bound and unbound ubiquitin conformers and study the level of residual induced fit after conformational selection in the binding process. We show that the region surrounding the binding site in ubiquitin undergoes conformational changes that are significantly more pronounced compared with the whole molecule on average. We demonstrate that these induced-fit structural adjustments are comparable in magnitude to conformational selection. Our final model of ubiquitin binding blends conformational selection with the subsequent induced fit and provides a quantitative measure of their respective contributions.