University of Warwick

About: University of Warwick is a education organization based out in Coventry, Warwickshire, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 26212 authors who have published 77127 publications receiving 2666552 citations. The organization is also known as: Warwick University & The University of Warwick.

Strategy or Structure? Capital, Labour and Control

Abstract: The literature on and for management makes increasing use of notions of strategy. Is such an approach compatible with analyses of capitalism as structurally determined? The first part of the paper ...

Identification of DypB from Rhodococcus jostii RHA1 as a lignin peroxidase.

Abstract: Rhodococcus jostii RHA1, a polychlorinated biphenyl-degrading soil bacterium whose genome has been sequenced, shows lignin degrading activity in two recently developed spectrophotometric assays. Bioinformatic analysis reveals two unannotated peroxidase genes present in the genome of R. jostii RHA1 with sequence similarity to open reading frames in other lignin-degrading microbes. They are members of the Dyp peroxidase family and were annotated as DypA and DypB, on the basis of bioinformatic analysis. Assay of gene deletion mutants using a colorimetric lignin degradation assay reveals that a ΔdypB mutant shows greatly reduced lignin degradation activity, consistent with a role in lignin breakdown. Recombinant DypB protein shows activity in the colorimetric assay and shows Michaelis–Menten kinetic behavior using Kraft lignin as a substrate. DypB is activated by Mn2+ by 5–23-fold using a range of assay substrates, and breakdown of wheat straw lignocellulose by recombinant DypB is observed over 24–48 h in the...

Meta-analysis, funnel plots and sensitivity analysis

Abstract: Publication bias is a major problem, perhaps the major problem, in meta-analysis (or systematic reviews). Small studies are more likely to be published if their results are 'significant' than if their results are negative or inconclusive, and so the studies available for review are biased in favour of those with positive outcomes. Correcting for this bias is not possible without making untestable assumptions. In this paper, a sensitivity analysis is suggested which is based on fitting a model to the funnel plot. Some examples are discussed.

Stellar population effects on the inferred photon density at reionization

Abstract: The relationship between stellar populations and the ionizing flux with which they irradiate their surroundings has profound implications for the evolution of the intergalactic medium (IGM). We quantify the ionizing flux arising from synthetic stellar populations which incorporate the evolution of interacting binary stars. We determine that these show ionizing flux boosted by 60 per cent at 0.05 ≤ Z ≤ 0.3 Z⊙ and a more modest 10–20 per cent at near-solar metallicities relative to star-forming populations in which stars evolve in isolation. The relation of ionizing flux to observables such as 1500 A continuum and ultraviolet spectral slope is sensitive to attributes of the stellar population including age, star formation history and initial mass function (IMF). For a galaxy forming 1 M⊙ yr−1, observed at >100 Myr after the onset of star formation, we predict a production rate of photons capable of ionizing hydrogen, Nion = 1.4 × 1053 s−1 at Z = Z⊙ and 3.5 × 1053 s−1 at 0.1 Z⊙, assuming a Salpeter-like IMF. We evaluate the impact of these issues on the ionization of the IGM, finding that the known galaxy populations can maintain the ionization state of the Universe back to z ∼ 9, assuming that their luminosity functions continue to MUV = −10, and that constraints on the IGM at z ∼ 2–5 can be satisfied with modest Lyman-continuum photon escape fractions of 4–24 per cent depending on assumed metallicity.