Institution
University of Warwick
Education•Coventry, Warwickshire, United Kingdom•
About: University of Warwick is a education organization based out in Coventry, Warwickshire, United Kingdom. It is known for research contribution in the topics: Population & Context (language use). The organization has 26212 authors who have published 77127 publications receiving 2666552 citations. The organization is also known as: Warwick University & The University of Warwick.
Papers published on a yearly basis
Papers
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TL;DR: In this article, a vocabulary and strategy for theorizing work and organizational practices is presented, based on the metaphorical movement of "zooming in" and "zooming out of" practice.
Abstract: This article contributes to re-specifying a number of the phenomena of interest to organizational studies in terms of patterns of socio-material practices and their effects. It does so by outlining a vocabulary and strategy that make up a framework for theorizing work and organizational practices. The vocabulary is based on number of sensitizing concepts that connote practice as an open-ended, heterogeneous accomplishment which takes place within a specific horizon of sense and a set of concerns which the practice itself brings to bear. The strategy is based on the metaphorical movement of ‘zooming in’ and ‘zooming out of’ practice. The zooming in and out are obtained through switching theoretical lenses and re-positioning in the field, so that certain aspects of the practice are fore-grounded while others are bracketed. Building on the results of an extended study of telemedicine, the article discusses in detail the different elements of the framework and how it enhances our capacity to re-present practi...
727 citations
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TL;DR: The application of metal-based catalysts dominates this area although simple anionic polymerisation and organocatalytic routes that demonstrate control of the polymer tacticity are discussed.
Abstract: The important advances and current trends in the stereocontrolled ring-opening polymerisation of lactide are discussed in this tutorial review. Microstructures, structural characterisation methods and the properties of stereoregular poly(lactide)s are examined. The application of metal-based catalysts dominates this area although simple anionic polymerisation and organocatalytic routes that demonstrate control of the polymer tacticity are discussed.
727 citations
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TL;DR: It is proposed that variable horizontal gene acquisition by B. pseudomallei is an important feature of recent genetic evolution and that this has resulted in a genetically diverse pathogenic species.
Abstract: Burkholderia pseudomallei is a recognized biothreat agent and the causative agent of melioidosis. This Gram-negative bacterium exists as a soil saprophyte in melioidosis-endemic areas of the world and accounts for 20% of community-acquired septicaemias in northeastern Thailand where half of those affected die. Here we report the complete genome of B. pseudomallei, which is composed of two chromosomes of 4.07 megabase pairs and 3.17 megabase pairs, showing significant functional partitioning of genes between them. The large chromosome encodes many of the core functions associated with central metabolism and cell growth, whereas the small chromosome carries more accessory functions associated with adaptation and survival in different niches. Genomic comparisons with closely and more distantly related bacteria revealed a greater level of gene order conservation and a greater number of orthologous genes on the large chromosome, suggesting that the two replicons have distinct evolutionary origins. A striking feature of the genome was the presence of 16 genomic islands (GIs) that together made up 6.1% of the genome. Further analysis revealed these islands to be variably present in a collection of invasive and soil isolates but entirely absent from the clonally related organism B. mallei. We propose that variable horizontal gene acquisition by B. pseudomallei is an important feature of recent genetic evolution and that this has resulted in a genetically diverse pathogenic species.
726 citations
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The Royal Marsden NHS Foundation Trust1, University of Birmingham2, National Health Service3, Australian National University4, University of Leicester5, Guy's Hospital6, University of Warwick7, University of Liverpool8, British Geological Survey9, University Hospitals Bristol NHS Foundation Trust10, St James's University Hospital11, Staffordshire University12, University Hospitals Birmingham NHS Foundation Trust13, University of Southampton14, Medical University of Vienna15, University Hospital of Basel16, Royal Liverpool University Hospital17
TL;DR: GEM-CAP should be considered as one of the standard first-line options in locally advanced and metastatic pancreatic cancer and the meta-analysis of published studies showed a significant survival benefit in favor of GEM- CAP.
Abstract: Purpose Both gemcitabine (GEM) and fluoropyrimidines are valuable treatment for advanced pancreatic cancer. This open-label study was designed to compare the overall survival (OS) of patients randomly assigned to GEM alone or GEM plus capecitabine (GEM-CAP).
Patients and Methods Patients with previously untreated histologically or cytologically proven locally advanced or metastatic carcinoma of the pancreas with a performance status ≤ 2 were recruited. Patients were randomly assigned to GEM or GEM-CAP. The primary outcome measure was survival. Meta-analysis of published studies was also conducted.
Results Between May 2002 and January 2005, 533 patients were randomly assigned to GEM (n = 266) and GEM-CAP (n = 267) arms. GEM-CAP significantly improved objective response rate (19.1% v 12.4%; P = .034) and progression-free survival (hazard ratio [HR], 0.78; 95% CI, 0.66 to 0.93; P = .004) and was associated with a trend toward improved OS (HR, 0.86; 95% CI, 0.72 to 1.02; P = .08) compared with GEM alone. This trend for OS benefit for GEM-CAP was consistent across different prognostic subgroups according to baseline stratification factors (stage and performance status) and remained after adjusting for these stratification factors (P = .077). Moreover, the meta-analysis of two additional studies involving 935 patients showed a significant survival benefit in favor of GEM-CAP (HR, 0.86; 95% CI, 0.75 to 0.98; P = .02) with no intertrial heterogeneity.
Conclusion On the basis of our trial and the meta-analysis, GEM-CAP should be considered as one of the standard first-line options in locally advanced and metastatic pancreatic cancer.
725 citations
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TL;DR: In this article, the authors present a review of the current literature concerning the high temperature polymer electrolylyte membrane (PEM) fuel cell, ranging from cell materials to stack and stack testing, and show that only acid doped PBI membranes meet the US DOE (US Department of Energy) targets for high temperature membranes operating under no humidification on both anode and cathode sides.
725 citations
Authors
Showing all 26659 results
Name | H-index | Papers | Citations |
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David Miller | 203 | 2573 | 204840 |
Daniel R. Weinberger | 177 | 879 | 128450 |
Kay-Tee Khaw | 174 | 1389 | 138782 |
Joseph E. Stiglitz | 164 | 1142 | 152469 |
Edmund T. Rolls | 153 | 612 | 77928 |
Thomas J. Smith | 140 | 1775 | 113919 |
Tim Jones | 135 | 1314 | 91422 |
Ian Ford | 134 | 678 | 85769 |
Paul Harrison | 133 | 1400 | 80539 |
Sinead Farrington | 133 | 1422 | 91099 |
Peter Hall | 132 | 1640 | 85019 |
Paul Brennan | 132 | 1221 | 72748 |
G. T. Jones | 131 | 864 | 75491 |
Peter Simmonds | 131 | 823 | 62953 |
Tim Martin | 129 | 878 | 82390 |