Institution
Uppsala University
Education•Uppsala, Sweden•
About: Uppsala University is a education organization based out in Uppsala, Sweden. It is known for research contribution in the topics: Population & Gene. The organization has 36485 authors who have published 107509 publications receiving 4220668 citations. The organization is also known as: Uppsala universitet & uu.se.
Topics: Population, Gene, Context (language use), Thin film, Receptor
Papers published on a yearly basis
Papers
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Russian Academy of Sciences1, Cardiff University2, University of Turku3, University of Gothenburg4, Uppsala University5, Moscow State University6, University of Helsinki7, University of Glasgow8, Umeå University9, University of Alcalá10, Spanish National Research Council11, Eötvös Loránd University12, Bangor University13
TL;DR: Trends in spring temperature varied markedly between study sites, and across populations the advancement of laying date was stronger in areas where the spring temperatures increased more, giving support to the theory that climate change causally affects breeding date advancement.
Abstract: Advances in the phenology of organisms are often attributed to climate change, but alternatively, may reflect a publication bias towards advances and may be caused by environmental factors unrelated to climate change. Both factors are investigated using the breeding dates of 25 long-term studied populations of Ficedula flycatchers across Europe. Trends in spring temperature varied markedly between study sites, and across populations the advancement of laying date was stronger in areas where the spring temperatures increased more, giving support to the theory that climate change causally affects breeding date advancement.
452 citations
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TL;DR: The results suggest that bacterial evolution to reduce the costs of antibiotic resistance can take different trajectories within and outside a host.
Abstract: Most types of antibiotic resistance impose a biological cost on bacterial fitness. These costs can be compensated, usually without loss of resistance, by second-site mutations during the evolution of the resistant bacteria in an experimental host or in a laboratory medium. Different fitness-compensating mutations were selected depending on whether the bacteria evolved through serial passage in mice or in a laboratory medium. This difference in mutation spectra was caused by either a growth condition-specific formation or selection of the compensated mutants. These results suggest that bacterial evolution to reduce the costs of antibiotic resistance can take different trajectories within and outside a host.
452 citations
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TL;DR: In this article, it was shown that a convex subset of Euclidean d-space R d is convex (concave) if the inequality F(OA + (1 O)B)
Abstract: Given subsets A and B of Euclidean d-space R a and 0 ~ 0, we set A + B -{x + Y l x E A, y E B} and OA = {Ox Ix 6 A }. Further given a convex subset g2 of R d we shall say that a set function F : 2 ~ \ {~} ~ [0, + ~ ] is convex (concave} if the inequality F(OA + (1 O)B) ~ Or(A} + (1 0 ) / ' ( B ) (>=.) holds for all It ~ A, B c_ D, and all 0 < 0 < 1. Here we shall s tudy such set functions of the special form given in the following
451 citations
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TL;DR: This review discusses Rubisco function in the context of structural variations at all levels--amino acid sequence, fold, tertiary and quaternary structure--with an evolutionary perspective and an emphasis on the structural features of the enzyme that may determine its function as a carboxylase.
451 citations
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TL;DR: The results suggest that state-of-the-art deep learning techniques can extract more prognostic information from the tissue morphology of colorectal cancer than an experienced human observer.
Abstract: Image-based machine learning and deep learning in particular has recently shown expert-level accuracy in medical image classification. In this study, we combine convolutional and recurrent architectures to train a deep network to predict colorectal cancer outcome based on images of tumour tissue samples. The novelty of our approach is that we directly predict patient outcome, without any intermediate tissue classification. We evaluate a set of digitized haematoxylin-eosin-stained tumour tissue microarray (TMA) samples from 420 colorectal cancer patients with clinicopathological and outcome data available. The results show that deep learning-based outcome prediction with only small tissue areas as input outperforms (hazard ratio 2.3; CI 95% 1.79-3.03; AUC 0.69) visual histological assessment performed by human experts on both TMA spot (HR 1.67; CI 95% 1.28-2.19; AUC 0.58) and whole-slide level (HR 1.65; CI 95% 1.30-2.15; AUC 0.57) in the stratification into low- and high-risk patients. Our results suggest that state-of-the-art deep learning techniques can extract more prognostic information from the tissue morphology of colorectal cancer than an experienced human observer.
451 citations
Authors
Showing all 36854 results
Name | H-index | Papers | Citations |
---|---|---|---|
Zhong Lin Wang | 245 | 2529 | 259003 |
Lewis C. Cantley | 196 | 748 | 169037 |
Darien Wood | 160 | 2174 | 136596 |
Kaj Blennow | 160 | 1845 | 116237 |
Christopher J. O'Donnell | 159 | 869 | 126278 |
Tomas Hökfelt | 158 | 1033 | 95979 |
Peter G. Schultz | 156 | 893 | 89716 |
Frederik Barkhof | 154 | 1449 | 104982 |
Deepak L. Bhatt | 149 | 1973 | 114652 |
Svante Pääbo | 147 | 407 | 84489 |
Jan-Åke Gustafsson | 147 | 1058 | 98804 |
Hans-Olov Adami | 145 | 908 | 83473 |
Hermann Kolanoski | 145 | 1279 | 96152 |
Kjell Fuxe | 142 | 1479 | 89846 |
Jan Conrad | 141 | 826 | 71445 |