Uppsala University

About: Uppsala University is a education organization based out in Uppsala, Sweden. It is known for research contribution in the topics: Population & Gene. The organization has 36485 authors who have published 107509 publications receiving 4220668 citations. The organization is also known as: Uppsala universitet & uu.se.

Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation

Abstract: Background Appropriate antithrombotic regimens for patients with atrial fibrillation who have an acute coronary syndrome or have undergone percutaneous coronary intervention (PCI) are uncl...

SVELTE: Real-time intrusion detection in the Internet of Things

Abstract: In the Internet of Things (IoT), resource-constrained things are connected to the unreliable and untrusted Internet via IPv6 and 6LoWPAN networks. Even when they are secured with encryption and authentication, these things are exposed both to wireless attacks from inside the 6LoWPAN network and from the Internet. Since these attacks may succeed, Intrusion Detection Systems (IDS) are necessary. Currently, there are no IDSs that meet the requirements of the IPv6-connected IoT since the available approaches are either customized for Wireless Sensor Networks (WSN) or for the conventional Internet. In this paper we design, implement, and evaluate a novel intrusion detection system for the IoT that we call SVELTE. In our implementation and evaluation we primarily target routing attacks such as spoofed or altered information, sinkhole, and selective-forwarding. However, our approach can be extended to detect other attacks. We implement SVELTE in the Contiki OS and thoroughly evaluate it. Our evaluation shows that in the simulated scenarios, SVELTE detects all malicious nodes that launch our implemented sinkhole and/or selective forwarding attacks. However, the true positive rate is not 100%, i.e., we have some false alarms during the detection of malicious nodes. Also, SVELTE's overhead is small enough to deploy it on constrained nodes with limited energy and memory capacity.

Survey of unlicensed and off label drug use in paediatric wards in European countries

Abstract: Objective: To determine the extent of use of unlicensed and off label drugs in children in hospital in five European countries. Design: Prospective study of drugs administered to children in general paediatric medical wards over four weeks. Setting: Children9s wards in five hospitals (one each in the United Kingdom, Sweden, Germany, Italy, and the Netherlands). Subjects: Children aged 4 days to 16 years admitted to general paediatric medical wards. Main outcome measure: Proportion of drugs that were used in an unlicensed or off label manner. Results: 2262 drug prescriptions were administered to 624 children in the five hospitals. Almost half of all drug prescriptions (1036; 46%) were either unlicensed or off label. Of these 1036, 872 were off label and 164 were unlicensed. Over half of the patients (421; 67%) received an unlicensed or off label drug prescription. Conclusions: Use of off label or unlicensed drugs to treat children is widespread. This problem is likely to affect children throughout Europe and requires European action. Key messages Many drugs are not tested in children, which means that they are not specifically licensed for use in children Licensed drugs are often prescribed outside the terms of the product license (off label) in relation to age, indication, dose of frequency, route of administration, or formulation Over two thirds (67%) of 624 children admitted to wards in five European hospitals received drugs prescribed in an unlicensed or off label manner 39% of the 2262 drug prescriptions given to children were off label The problem of off label and unlicensed drug prescribing in children is a European problem that requires European action