Weingarten Realty Investors

About: Weingarten Realty Investors is a based out in . It is known for research contribution in the topics: Mobile robot & Piston. The organization has 892 authors who have published 1284 publications receiving 12726 citations.

Cyclical supply device for workpieces

Abstract: The device is used for the cyclical supply of workpieces to a processing or handling station The supply system incorporates a first transport system (1,2,3,4) and a second, parallel transport system (10,11,13) The workpieces (5) are cyclically transferred via these two systems, which are connected to each other via a workpiece transfer device (7) The first system is the main conveyor (1), and the second systems the auxiliary conveyor (10) Gliding slides (2,11) are provided, interrupted by the workpiece transfer device, whereby workpieces are simultaneously pushed onto and off the transfer device

Programmable claw for a robot - Has computer, servo controller and amplifier integrated in claw, with circuitry inside housing connected by multi-pin plug

Abstract: A freely programmable claw for a robot has computer (10), a servo controller and an amplifier (17) integrated within the claw for its electronic control. The major part of the circuitry and components are housed in a closed unit, connected to the claw by a multi-pin plug. The weight of the claw is 3 kg at the most. The claw is attached to the robot at a flange (1). There is a rotary mount (5) moving about an axis (6) and carrying six or seven suction fingers (7). There are also vacuum and force sensors. ADVANTAGE - Flexible in use and improved reliability.

Re: A. Bauernfeind et al.: Comparative pharmacodynamics of clarithromycin and azithromycin against respiratory pathogens (Infection 23 [1995] 316-321)

Abstract: The publication of the above by Bauernfeind et al. elicits criticism with regard to scientific and methodological principles and especially regarding the resulting therapeutic conclusions. To substantiate this we would like to refer to the following points: 1) Experimental models comparing macrolide antibiotics on the basis of their serum concentrations are of no significance. It is well known that for this class of antibiotics, tissue concentrations in particular in phagocytizing cells are of greater importance for therapeutic success than serum concentrations. 2) The serum kinetics selected in the study by Bauernfeind et al. are not representative. For clarithromycin, a steady state concentration has been chosen as maximum level, for azithromycin on the other hand, the concentration chosen is from a study using a single application in only six subjects. The data available for azithromycin from the international literature are nearly twice as high. This makes the entire experimental kinetic approach in this study very problematic. 3) The selection and very low number of test organisms is also highly questionable. Many studies show a mean MIC of 4-8 mg/1 for Haemophilus influenzae versus clarithromycin, whereas concentrations for azithromycin range between 0.5 and I rag/1. The selection of test strains is accordingly by no means representative, and combined with the low number of organisms tested do not allow for a conclusive comparison. 4) The hypothesis regarding the development of resistant mutants has no clinical correlation. This is the case especially with regard to the fact that in this study highly susceptible organisms show an unfavorable change of their MIC values during the course of exposure to the antibiotic, whereas organisms with primarily high MIC values do not show such a development, The possibility of selection of resistant mutants is highly dependent on the inoculum. Therefore, choosing an initial inoculum with a load suitable for measuring bactericidal kinetics (106 CFU/ml) rather than an inoculum featuring a load equivalent to that which one could expect to find in the blood of patients with bacteremic respiratory tract infections appears to be unrealistic. In addition, a difference in resistance development between various macrolide antibiotics has never been observed clinically. 5) Even in bacteremic pneumococcal pneumonias, highest therapeutic importance must be accorded to the bactericidal reduction of organisms primarily at the infection site. Furthermore, organisms circulating in the intravascular space are phagocytized by granulocytes, or by the macrophages in organs with a high content of reticulo-endothelial cells. Macrolides, and in particular azithromycin, are highly concentrated in these cells and the factor of this concentration is approximately 10 to 20 for clarithromycin and approximately 50 to 100 for azithromycin. The clinical results available to date concerning azithromycin in bacteremic pneumococcal pneumonias show the same success or failure rates as seen with other groups of substances. D. Adam, H. Grimm, H. Lode