Showing papers in "Advanced Drug Delivery Reviews in 1998"

TL;DR: By selection of the type of alginate and coating agent, the pore size, degradation rate, and ultimately release kinetics can be controlled.

TL;DR: 'Intelligent' amphiphilic copolymers emerge as a novel trend in the application of thermodynamically stable self-assembling lyophilic colloids to protein and peptide delivery.

TL;DR: Experimental data show that sustained release of growth factor from the gelatin hydrogels is very effective in exerting the biological functions of the growth factor.

TL;DR: Limitations of aluminum adjuvants include local reactions, augmentation of IgE antibody responses, ineffectiveness for some antigens and inability to augment cell-mediated immune responses, especially cytotoxic T-cell responses.

TL;DR: The inflammatory response to the biomaterial component and immune response towards transplanted cells are described and examples of devices appropriately integrated as assessed morphologically with the host for various applications including bone, nerve, and skin regeneration are illustrated.

TL;DR: Receptor-mediated gene transfer employs a DNA-binding polycation to compact plasmid DNA to a size that can be taken up by cells to allow internalization by receptor-mediated endocytosis.

TL;DR: The present review focuses on the gastrointestinal bioadhesion of micro- and nanoparticles in the gastrointestinal tract, and proposes a strategy to associate drugs to polymeric nanoparticulate systems because of their propensity to interact with the mucosal surface.

TL;DR: Present knowledge of the biodistribution and cellular interactions of gene delivery systems are summarized and how improvements in gene delivery will be accomplished in the future are considered.

TL;DR: Several approaches are discussed to increase the residence time of drug formulations in the nasal cavity, resulting in improved nasal drug absorption, however, more experimental evidence is needed to support the conclusion that this improved absorption is caused by a longer residenceTime of the nasal drug formulation.

TL;DR: Experience using cell/polymer constructs to guide regeneration of diverse tissues, e.g. liver, intestine, urologic tissue, skin, cartilage, bone and cardiovascular structures is presented and the concept of applying tissue-engineered structures to non-native sites is discussed.

TL;DR: This article will focus on the experiences with liposome-blood protein interactions and how alterations in the chemical and physical properties of the carrier system influence the interactions with blood proteins and circulation times.

TL;DR: In studying drug absorption from the nasal mucous membrane, it is essential to have a clear understanding of anatomy and physiology of the nose, and how it relates to the characteristics of the delivery system used.

TL;DR: Physico-chemical aspects of formation and behavior of interpolyelectrolyte and block ionomers complexes are discussed and recent results on the use of block ionomer complexes for gene delivery are presented.

TL;DR: Technologies applicable to directing liposomes and their contents to selected in vivo targets using surface-bound, site-specific ligands are reviewed and several novel targets as well as novel ligand constructs for site-directed therapy are reviewed.

TL;DR: The roles of the mucus and mucosal cell layers are discussed along with technologies and strategies that may be used to improve uptake, including attempts to determine the mechanisms of microparticulate uptake into enterocytes and membranous epithelial (M) cells.

TL;DR: Refinement of existing immunotoxins and development of new immunOToxins are underway to improve the treatment of cancer.

TL;DR: The adjuvant effect of PLG microparticles are discussed, and their potential for the development of single-dose vaccines through the use of controlled-release technology is discussed.

TL;DR: Organized cell communities are defined as three-dimensional in vitro grown cell-polymer constructs that display important structural and functional features of the natural tissue that can potentially serve as tissue equivalents for in vivo transplantation.

TL;DR: The incorporation of polymer-lipid conjugates, initially using PEG and subsequently other selected flexible, hydrophilic polymers, into lipid bilayers gives rise to sterically stabilized liposomes that exhibit reduced blood clearance and concomitant changes in tissue distribution largely because of reduction in phagocytic uptake.

TL;DR: A description of newer, more potent and specific antibody-drug conjugates, which behave like tumor-activated prodrugs that may yet fulfil the promise of the targeted delivery approach for the treatment of cancer.

TL;DR: The aim of this paper is to review the principal studies where peptide-loaded particles were administered by the oral route and in vivo results are discussed with emphasis placed on the peptide blood levels reached or on the biological effects observed.

TL;DR: A multiplicity of physicochemical and physiopathological factors which influence the clearance kinetics and tissue distribution of liposomes administered into the circulation are addressed.

TL;DR: The basic technology of controlled protein delivery using polymeric materials is outlined, and some of the techniques under investigation for the efficient administration of proteins in tissue engineering are discussed.

TL;DR: The mode of action, the nature of the complexes formed with DNA and the transfection potentials of two categories of inert, cationic vectors, the lipospermines and polyethylenimine are considered, which are among the best vectors currently available for in vitro work.

TL;DR: In vitro and in vivo methods have been used to study distribution and clearance of intranasally delivered therapeutics and the relationship between deposition, absorption and related bioavailability of the nasally applied formulation has been shown.

TL;DR: This review briefly covers the use of saponins for animal vaccines but focuses mainly on the development of these adjuvants for use in man and important aspects include preparation of purified or highly defined saponin fractions, improved understanding of the relationships between adjuvant activity, toxicity and structure of Saponins and formulation of sap onins into structures with reduced toxicity such as ISCOMs.

TL;DR: Although the precise mechanism of VEGF's permeabilising action is not yet understood, it is likely to contribute to the enhanced permeability and retention (EPR) effect in tumours which is thought to underlie the anticancer activity of macromolecular drugs.

TL;DR: This chapter deals with animal techniques to study nasal absorption and the effect of physico-chemical and biopharmaceutical properties of drugs on the rate and extent of absorption.

TL;DR: Although encouraging results have been obtained with the use of synthetic peptides to enhance cellular delivery of various compounds, the naturally evolved mechanisms observed in the entry of viruses or protein toxins are still far more efficient.