Journal ArticleDOI
A Multilayer Grow-or-Go Model for GBM: Effects of Invasive Cells and Anti-Angiogenesis on Growth
TLDR
A new mathematical model is derived that takes into account the ability of proliferative cells to become invasive under hypoxic conditions; model simulations generate the multilayer structure of GBM, namely proliferation, brain invasion, and necrosis.About:
This article is published in Bulletin of Mathematical Biology.The article was published on 2014-08-23. It has received 57 citations till now. The article focuses on the topics: Angiogenesis.read more
Citations
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Journal ArticleDOI
Current Challenges in Glioblastoma: Intratumour Heterogeneity, Residual Disease, and Models to Predict Disease Recurrence
Hayley P Ellis,Mark Greenslade,Ben Powell,Inmaculada Spiteri,Andrea Sottoriva,Kathreena M Kurian +5 more
TL;DR: M Mathematical modeling and strategies such as multiple sampling during tumor resection and genetic analysis of circulating cancer cells, may be of great future benefit to help predict the nature of residual disease and resistance to standard and molecular therapies in GB.
Proceedings ArticleDOI
Attention-Guided Version of 2D UNet for Automatic Brain Tumor Segmentation
TL;DR: A low-parameter network based on 2D UNet in which an attention mechanism is adopted after concatenation of low-level and high-level features and the Multi-View Fusion can benefit from 3D contextual information of input images despite using a 2D model.
Journal ArticleDOI
Towards the Design of a Patient-Specific Virtual Tumour.
Flavien Caraguel,Anne-Cécile Lesart,François Estève,Boudewijn van der Sanden,Angélique Stéphanou +4 more
TL;DR: An integrated hybrid and multiscale approach has been developed based on data acquired on a preclinical mouse model as a proof of concept to build case-specific virtual tumours that matches the characteristics and spatiotemporal evolution of its real counterpart.
Journal ArticleDOI
BU-Net: Brain Tumor Segmentation Using Modified U-Net Architecture
TL;DR: The proposed BU-Net outperformed the existing state-of-the-art techniques and can have a great contribution to researchers from the field of bioinformatics and medicine.
Journal ArticleDOI
Effects of Anti-Angiogenesis on Glioblastoma Growth and Migration: Model to Clinical Predictions
Elizabeth Scribner,Olivier Saut,Paula Province,Asim K. Bag,Thierry Colin,Hassan M. Fathallah-Shaykh +5 more
TL;DR: A clinical-scale model of GBM is constructed whose predictions uncover a new pattern of recurrence in 11/70 bevacizumab-treated patients and support an exception to the Folkman hypothesis: GBM grows in the absence of angiogenesis by a cycle of proliferation and brain invasion that expands necrosis.
References
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Journal ArticleDOI
The 2007 WHO Classification of Tumours of the Central Nervous System
David N. Louis,Hiroko Ohgaki,Otmar D. Wiestler,Webster K. Cavenee,Peter C. Burger,Anne Jouvet,Bernd W. Scheithauer,Paul Kleihues +7 more
TL;DR: The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneurs tumour of the fourth ventricle, Papillary tumourof the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
Journal ArticleDOI
Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group
Patrick Y. Wen,David R. Macdonald,David A. Reardon,Timothy F. Cloughesy,A. Gregory Sorensen,Evanthia Galanis,John DeGroot,Wolfgang Wick,Mark R. Gilbert,Andrew B. Lassman,Christina Tsien,Tom Mikkelsen,Eric T. Wong,Marc C. Chamberlain,Roger Stupp,Kathleen R. Lamborn,Michael A. Vogelbaum,Martin J. van den Bent,Susan M. Chang +18 more
TL;DR: The recognition that contrast enhancement is nonspecific and may not always be a true surrogate of tumor response and the need to account for the nonenhancing component of the tumor mandate that new criteria be developed and validated to permit accurate assessment of the efficacy of novel therapies.
Journal ArticleDOI
Bevacizumab Alone and in Combination With Irinotecan in Recurrent Glioblastoma
Henry S. Friedman,Michael D. Prados,Patrick Y. Wen,Tom Mikkelsen,David Schiff,Lauren E. Abrey,W. K. Alfred Yung,Nina Paleologos,Martin K. Nicholas,Randy L. Jensen,James J. Vredenburgh,Jane Huang,Maoxia Zheng,Timothy F. Cloughesy +13 more
TL;DR: Bvacizumab, alone or in combination with irinotecan, was well tolerated and active in recurrent glioblastoma in a phase II, multicenter, open-label, noncomparative trial.
Journal ArticleDOI
A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma
Mark R. Gilbert,James J. Dignam,Terri S. Armstrong,Terri S. Armstrong,Jeffrey S. Wefel,Deborah T. Blumenthal,Michael A. Vogelbaum,Howard Colman,Arnab Chakravarti,Stephanie L. Pugh,Minhee Won,Robert Jeraj,Paul D. Brown,Kurt A. Jaeckle,David Schiff,Volker W. Stieber,David Brachman,Maria Werner-Wasik,Ivo W. Tremont-Lukats,Erik P. Sulman,Kenneth Aldape,Walter J. Curran,Minesh P. Mehta +22 more
TL;DR: First-line use of bevacizumab did not improve overall survival in patients with newly diagnosed glioblastoma, and progression-free survival was prolonged but did not reach the prespecified improvement target.
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