Journal ArticleDOI
A rating scale for mania: reliability, validity and sensitivity.
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The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently, and also correlated with the number of days of subsequent stay in hospital.Abstract:
An eleven item clinician-administered Mania Rating Scale (MRS) is introduced, and its reliability, validity and sensitivity are examined. There was a high correlation between the scores of two independent clinicians on both the total score (0.93) and the individual item scores (0.66 to 0.92). The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently. The score also correlated with the number of days of subsequent stay in hospital. It was able to differentiate statistically patients before and after two weeks of treatment and to distinguish levels of severity based on the global rating.read more
Citations
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Attenuation of the Neuropsychiatric Effects of Ketamine With Lamotrigine: Support for Hyperglutamatergic Effects of N-methyl-D-aspartate Receptor Antagonists
Amit Anand,Dennis S. Charney,Dan A. Oren,Robert M. Berman,X. S. Hu,Angela Cappiello,J.H. Krystal +6 more
TL;DR: The hypothesis that lamotrigine, a drug reported to inhibit glutamate release, will reduce the neuropsychiatric effects of ketamine in humans is tested and it is suggested that glutamate release-inhibiting drugs may reduce the hyperglutamatergic consequences of NMDA receptor dysfunction implicated in the pathophysiologic processes of neuro psychological illnesses such as schizophrenia.
Journal ArticleDOI
Brain metabolic alterations in medication-free patients with bipolar disorder
Stephen R. Dager,Seth D. Friedman,Aimee Parow,Christina M. Demopulos,Andrew L. Stoll,In Kyoon Lyoo,David L. Dunner,Perry F. Renshaw +7 more
TL;DR: Gray matter lactate and Glx elevations in medication-free BD patients suggest a shift in energy redox state from oxidative phosphorylation toward glycolysis, and may provide a theoretical framework for future targeted treatment interventions.
Journal ArticleDOI
Neurocognitive impairment in euthymic patients with bipolar affective disorder.
Jill M. Thompson,Peter Gallagher,John H. Hughes,Stuart Watson,John M. Gray,I. Nicol Ferrier,Allan H. Young +6 more
TL;DR: Neurocognitive impairment persists in patients whose bipolar disorder is in remission and may represent a trait abnormality and be a marker of underlying neurobiological dysfunction.
Journal ArticleDOI
Independent assessment of manic and depressive symptoms by self-rating. Scale characteristics and implications for the study of mania.
Mark S. Bauer,Paul Crits-Christoph,William A. Ball,Edward Dewees,Thomas W. McAllister,Peter Alahi,John S. Cacciola,Peter C. Whybrow +7 more
TL;DR: Bimodal distribution of scores of manic patients on the Well-Being and Depression Index subscales substantiated earlier findings that euphoric mood is not an essential feature of mania and proposed that variables related to activation level and not to mood state constitute the core characteristics of the manic syndrome.
Journal ArticleDOI
Brain-derived neurotrophic factor and inflammatory markers in patients with early- vs. late-stage bipolar disorder.
Márcia Kauer-Sant'Anna,Márcia Kauer-Sant'Anna,Flávio Kapczinski,Ana Cristina Andreazza,Ana Cristina Andreazza,David J. Bond,Raymond W. Lam,L. Trevor Young,Lakshmi N. Yatham +8 more
TL;DR: Examination of cytokine and BDNF levels in bipolar I disorder patients found that failure of inflammatory defences in the late stage of the disorder may account for reduction in BDNF and continued elevations in cytokines; thus these have the potential to serve as markers of illness progression in BD.
References
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Book
Nonparametric statistics for the behavioral sciences
TL;DR: This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others as discussed by the authors, and the original structure is retained, and the book continues to serve as a combined text/reference.
Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
Journal ArticleDOI
The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
Journal ArticleDOI
Diagnostic criteria for use in psychiatric research.
John P. Feighner,Eli Robins,Samuel B. Guze,Robert A. Woodruff,George Winokur,Rodrigo A. Munoz +5 more
TL;DR: Diagnostic criteria for 14 psychiatric illnesses along with the validating evidence for these diagnostic categories comes from workers outside the authors' group as well as from those within; it consists of studies of both outpatients and inpatients, of family studies, and of follow-up studies.