Journal ArticleDOI
A rating scale for mania: reliability, validity and sensitivity.
TLDR
The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently, and also correlated with the number of days of subsequent stay in hospital.Abstract:
An eleven item clinician-administered Mania Rating Scale (MRS) is introduced, and its reliability, validity and sensitivity are examined. There was a high correlation between the scores of two independent clinicians on both the total score (0.93) and the individual item scores (0.66 to 0.92). The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently. The score also correlated with the number of days of subsequent stay in hospital. It was able to differentiate statistically patients before and after two weeks of treatment and to distinguish levels of severity based on the global rating.read more
Citations
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A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression
Carlos A. Zarate,Jaskaran Singh,Paul J. Carlson,Nancy E. Brutsche,Rezvan Ameli,David A. Luckenbaugh,Dennis S. Charney,Husseini K. Manji +7 more
TL;DR: Robust and rapid antidepressant effects resulted from a single intravenous dose of an N-methyl-D-aspartate antagonist; onset occurred within 2 hours postinfusion and continued to remain significant for 1 week.
Journal ArticleDOI
Subgenual prefrontal cortex abnormalities in mood disorders
Wayne C. Drevets,Joseph L. Price,Joseph R. Simpson,Richard D. Todd,Theodore Reich,Michael W. Vannier,Michael W. Vannier,Marcus E. Raichle +7 more
TL;DR: Using positron emission tomographic images of cerebral blood flow and rate of glucose metabolism to measure brain activity, an area of abnormally decreased activity is localized in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives.
Journal ArticleDOI
Lifetime and 12-Month Prevalence of Bipolar Spectrum Disorder in the National Comorbidity Survey Replication
Kathleen R. Merikangas,Hagop S. Akiskal,Jules Angst,Paul E. Greenberg,Robert M. A. Hirschfeld,Maria Petukhova,Ronald C. Kessler +6 more
TL;DR: This study presents the first prevalence estimates of the BPD spectrum in a probability sample of the United States, and finds subthreshold BPD is common, clinically significant, and underdetected in treatment settings.
Journal ArticleDOI
Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative.
Kathleen R. Merikangas,Robert Jin,Jian-Ping He,Ronald C. Kessler,Sing Lee,Nancy A. Sampson,Maria Carmen Viana,Laura Helena Andrade,Chiyi Hu,Elie G. Karam,Maria Ladea,María Elena Medina-Mora,Yutaka Ono,Jose Posada-Villa,Rajesh Sagar,J. Elisabeth Wells,Zahari Zarkov +16 more
TL;DR: The uniform increases in clinical correlates, suicidal behavior, and comorbidity across each diagnostic category provide evidence for the validity of the concept of BPS.
Journal ArticleDOI
Reduction of prefrontal cortex glucose metabolism common to three types of depression.
Lewis R. Baxter,Jeffrey M. Schwartz,Michael E. Phelps,John C. Mazziotta,Barry H. Guze,Carl Selin,Robert H. Gerner,Ron M. Sumida +7 more
TL;DR: Using positron emission tomography, cerebral glucose metabolism in drug-free, age- and sex-matched, right-handed patients with unipolar depression, bipolar depression, obsessive-compulsive disorder (OCD) with secondary depression, OCD without major depression, and normal controls is studied.
References
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Journal ArticleDOI
The Stages of Mania: A Longitudinal Analysis of the Manic Episode
TL;DR: The progression of symptoms during an acute manic episode was studied retrospectively in 20 bipolar manic-depressive patients whose diagnosis was reconfirmed at follow-up, and the advantages of using a longitudinal view of a psychotic episode as a diagnostic tool are discussed.
Journal ArticleDOI
The Manic-State Rating Scale: Scale Construction, Reliability, and Validity
TL;DR: It is suggested that the further evaluation of manic and hypomanic patients using the MS Scale may yield items which will help to define individual differences among manic patients.
Journal ArticleDOI
Psychoactive drugs in mania. A controlled comparison of lithium carbonate, chlorpromazine, and haloperidol
TL;DR: Qualitative differences between lithium carbonate and haloperidol indicate that, while haloperodol has a more dramatically rapid impact on behavior-motor activity, lithium Carbonate acted more evenly on the entire manic picture, with total normalization realized during active treatment.
Journal ArticleDOI
Assessing Clinical Characteristics of the Manic State
Allan Beigel,Dennis L. Murphy +1 more
TL;DR: The authors found that 11 of the 26 items of the Manic-State Rating Scale characterized common elements of mania in 12 manic-depressive patients and that these items were highly correlated with independent ratings of change in the severity of manIA.
Journal ArticleDOI
Depression, Elation, and Lithium Carbonate Responses in Manic Patient Subgroups
Dennis L. Murphy,Allen Beigel +1 more
TL;DR: A factor analysis of the scale confirmed a "core" group of manic symptoms as well as a dichotomous grouping of elated-grandiose (E-G) and paranoid-destructive (P-D) patients and suggested a close relationship between the presence of rated depression during mania and the particular symptomatic complex found in the P-D subgroup of manic patients.