Journal ArticleDOI
A rating scale for mania: reliability, validity and sensitivity.
TLDR
The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently, and also correlated with the number of days of subsequent stay in hospital.Abstract:
An eleven item clinician-administered Mania Rating Scale (MRS) is introduced, and its reliability, validity and sensitivity are examined. There was a high correlation between the scores of two independent clinicians on both the total score (0.93) and the individual item scores (0.66 to 0.92). The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently. The score also correlated with the number of days of subsequent stay in hospital. It was able to differentiate statistically patients before and after two weeks of treatment and to distinguish levels of severity based on the global rating.read more
Citations
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Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder
Seth D. Friedman,Stephen R. Dager,Aimee Parow,Fuyuki Hirashima,Christina M. Demopulos,Andrew L. Stoll,In Kyoon Lyoo,David L. Dunner,Perry F. Renshaw +8 more
TL;DR: Li treatment of BP was associated with specific GM Glx decreases and myo-inositol increases and Findings are discussed in the context of cellular mechanisms postulated to underlie Li and VPA therapeutic efficacy.
Journal ArticleDOI
Subthreshold symptoms in bipolar disorder: impact on neurocognition, quality of life and disability.
Caterina del Mar Bonnín,José Sánchez-Moreno,Anabel Martínez-Arán,Brisa Solé,María Reinares,Adriane R. Rosa,Jose Manuel Goikolea,Antoni Benabarre,J.L. Ayuso-Mateos,Montse Ferrer,Eduard Vieta,Carla Torrent +11 more
TL;DR: Empirical data is presented suggesting a moderate impact of subthreshold symptoms on functioning/disability and QoL and a discrete impact on neuropsychological impairment in bipolar disorder patients.
Journal ArticleDOI
Abnormal frontal lobe phosphorous metabolism in bipolar disorder.
TL;DR: This preliminary study provides support for abnormal frontal lobe phosphorous metabolism in bipolar disorder by finding patients with bipolar disorder had significantly lower phosphomonoester values and higher phosphodiester values in both the left and right frontal lobes.
Journal ArticleDOI
Gray Matter Volume as an Intermediate Phenotype for Psychosis: Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP)
Elena I. Ivleva,Anup S. Bidesi,Matcheri S. Keshavan,Godfrey D. Pearlson,Shashwath A. Meda,Darko Dodig,Amanda F. Moates,Hanzhang Lu,Alan N. Francis,Neeraj Tandon,David J. Schretlen,John A. Sweeney,Brett A. Clementz,Carol A. Tamminga +13 more
TL;DR: Findings indicate extensive neocortical gray matter reductions in psychosis probands and relatives with psychosis spectrum disorders, possibly reflecting lifetime psychosis burden, but normal gray matter in nonpsychotic relatives.
Journal ArticleDOI
An 8-Week Randomized, Double-Blind, Placebo-Controlled Evaluation of the Safety and Efficacy of Cariprazine in Patients With Bipolar I Depression
Suresh Durgam,Willie Earley,Alan Lipschitz,Hua Guo,István Laszlovszky,György Németh,Eduard Vieta,Joseph R. Calabrese,L Yatham +8 more
TL;DR: Cariprazine at 1.5 mg/day demonstrated consistent efficacy compared with placebo across outcomes and was generally well tolerated, suggesting efficacy for the treatment of bipolar I depression.
References
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Book
Nonparametric statistics for the behavioral sciences
TL;DR: This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others as discussed by the authors, and the original structure is retained, and the book continues to serve as a combined text/reference.
Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
Journal ArticleDOI
The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
Journal ArticleDOI
Diagnostic criteria for use in psychiatric research.
John P. Feighner,Eli Robins,Samuel B. Guze,Robert A. Woodruff,George Winokur,Rodrigo A. Munoz +5 more
TL;DR: Diagnostic criteria for 14 psychiatric illnesses along with the validating evidence for these diagnostic categories comes from workers outside the authors' group as well as from those within; it consists of studies of both outpatients and inpatients, of family studies, and of follow-up studies.