Journal ArticleDOI
A rating scale for mania: reliability, validity and sensitivity.
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TLDR
The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently, and also correlated with the number of days of subsequent stay in hospital.Abstract:
An eleven item clinician-administered Mania Rating Scale (MRS) is introduced, and its reliability, validity and sensitivity are examined. There was a high correlation between the scores of two independent clinicians on both the total score (0.93) and the individual item scores (0.66 to 0.92). The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently. The score also correlated with the number of days of subsequent stay in hospital. It was able to differentiate statistically patients before and after two weeks of treatment and to distinguish levels of severity based on the global rating.read more
Citations
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Effect of symptoms on executive function in bipolar illness
TL;DR: Executive function deficits in bipolar I disorder are most evident during mania, and are particularly associated with formal thought disorder, however, deficits in response initiation, strategic thinking and inhibitory control may be more related to the underlying disorder than a particular symptom profile.
Journal ArticleDOI
Elevated Cerebrospinal Fluid Lactate Concentrations in Patients with Bipolar Disorder and Schizophrenia: Implications for the Mitochondrial Dysfunction Hypothesis
William T. Regenold,Pornima Phatak,Christopher Marano,Amritpal Sassan,Robert R. Conley,Mitchel A. Kling +5 more
TL;DR: This is the first report of increased CSF lactate concentrations in patients with bipolar disorder and schizophrenia, which indicates increased extra-mitochondrial and anaerobic glucose metabolism and is consistent with impaired mitochondrial metabolism.
Journal ArticleDOI
Multi-family psychoeducation groups in the treatment of children with mood disorders.
TL;DR: Results are largely consistent with hypothesized findings and support the need to further investigate the adjunctive role of psychoeducation in the treatment of childhood mood disorders.
Journal ArticleDOI
Functional Magnetic Resonance Imaging Brain Activation in Bipolar Mania: Evidence for Disruption of the Ventrolateral Prefrontal-Amygdala Emotional Pathway
Stephen M. Strakowski,James C. Eliassen,Martine Lamy,Michael A. Cerullo,Jane B. Allendorfer,Michelle Madore,Jing-Huei Lee,Jeffrey A. Welge,Melissa P. DelBello,David E. Fleck,Caleb M. Adler +10 more
TL;DR: Bipolar manic subjects exhibit blunted brain fMRI response to emotional cues throughout the ventrolateral prefrontal emotional arousal network, which may contribute to the mood dysregulation of bipolar disorder.
Journal ArticleDOI
Impaired Inter-Hemispheric Integration in Bipolar Disorder Revealed with Brain Network Analyses
Alex D. Leow,Olusola Ajilore,Liang Zhan,Donatello Arienzo,Johnson GadElkarim,Aifeng Zhang,Teena D. Moody,John D. Van Horn,Jamie D. Feusner,Anand Kumar,Paul M. Thompson,Lori L. Altshuler +11 more
TL;DR: Network analyses revealed that the bipolar brain networks exhibited significantly longer characteristic path length, lower clustering coefficient, and lower global efficiency relative to those of control subjects, and abnormalities in structural network organization in bipolar disorder, particularly in inter-hemispheric integration and within the limbic system.
References
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Book
Nonparametric statistics for the behavioral sciences
TL;DR: This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others as discussed by the authors, and the original structure is retained, and the book continues to serve as a combined text/reference.
Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
Journal ArticleDOI
The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
Journal ArticleDOI
Diagnostic criteria for use in psychiatric research.
John P. Feighner,Eli Robins,Samuel B. Guze,Robert A. Woodruff,George Winokur,Rodrigo A. Munoz +5 more
TL;DR: Diagnostic criteria for 14 psychiatric illnesses along with the validating evidence for these diagnostic categories comes from workers outside the authors' group as well as from those within; it consists of studies of both outpatients and inpatients, of family studies, and of follow-up studies.