Journal ArticleDOI
A rating scale for mania: reliability, validity and sensitivity.
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TLDR
The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently, and also correlated with the number of days of subsequent stay in hospital.Abstract:
An eleven item clinician-administered Mania Rating Scale (MRS) is introduced, and its reliability, validity and sensitivity are examined. There was a high correlation between the scores of two independent clinicians on both the total score (0.93) and the individual item scores (0.66 to 0.92). The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently. The score also correlated with the number of days of subsequent stay in hospital. It was able to differentiate statistically patients before and after two weeks of treatment and to distinguish levels of severity based on the global rating.read more
Citations
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The efficacy of N-acetylcysteine as an adjunctive treatment in bipolar depression: An open label trial ☆
Michael Berk,Olivia M Dean,Olivia M Dean,Olivia M Dean,Sue M. Cotton,Clarissa Severino Gama,Flávio Kapczinski,Brisa Simoes Fernandes,Kristy Kohlmann,Sue Jeavons,Sue Jeavons,Karen Hewitt,Christine Allwang,Christine Allwang,H. Cobb,Ashley I. Bush,Ian Schapkaitz,Seetal Dodd,Seetal Dodd,Gin S Malhi +19 more
TL;DR: These open label data demonstrate a robust decrement in depression scores with NAC treatment, and large placebo controlled trials of acute bipolar depression are warranted.
Journal ArticleDOI
Selective DNA Methylation of BDNF Promoter in Bipolar Disorder: Differences Among Patients with BDI and BDII
Claudio D'Addario,Bernardo Dell'Osso,Maria Carlotta Palazzo,Beatrice Benatti,L. Lietti,E. Cattaneo,Daniela Galimberti,Chiara Fenoglio,Francesca Cortini,Elio Scarpini,Beatrice Arosio,Andrea Di Francesco,Manuela Di Benedetto,Patrizia Romualdi,Sanzio Candeletti,Daniela Mari,Luigi Bergamaschini,Nereo Bresolin,Mauro Maccarrone,A. Carlo Altamura +19 more
TL;DR: Findings suggest selective changes in DNA methylation of BDNF promoter in subjects with BD type II and highlight the importance of epigenetic factors in mediating the onset and/or susceptibility to BD, providing new insight into the mechanisms of gene expression.
Journal ArticleDOI
Neuroinflammation in bipolar disorder : A [C-11]-(R)-PK11195 positron emission tomography study
Bartholomeus C M Haarman,Rixt F. Riemersma-van der Lek,Jan Cees de Groot,Henricus G. Ruhé,Hans C. Klein,Tjitske E Zandstra,Huibert Burger,Robert A. Schoevers,Erik F. J. de Vries,Hemmo A. Drexhage,Willem A. Nolen,Janine Doorduin +11 more
TL;DR: This study is the first to demonstrate the presence of focal neuroinflammation in the right hippocampus in bipolar I disorder and significantly increased [(11)C]-(R)-PK11195 binding potential, which is indicative of Neuroinflammation.
Journal ArticleDOI
Quality of life and lifestyle disruption in euthymic bipolar disorder.
TL;DR: It seems apparent that quality of life, as determined by illness intrusiveness, is compromised in subjects with BD even during periods of euthymia, and specific psychosocial interventions aimed at reducing the impact of BD should be determined.
Journal ArticleDOI
Mania and ADHD: comorbidity or confusion.
TL;DR: It is clear that a significant number of preadolescents found in outpatient and inpatient samples meet at least symptom criteria for bipolar disorder and have significant comorbidity and impairment.
References
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Book
Nonparametric statistics for the behavioral sciences
TL;DR: This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others as discussed by the authors, and the original structure is retained, and the book continues to serve as a combined text/reference.
Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
Journal ArticleDOI
The Brief Psychiatric Rating Scale
John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
Journal ArticleDOI
Diagnostic criteria for use in psychiatric research.
John P. Feighner,Eli Robins,Samuel B. Guze,Robert A. Woodruff,George Winokur,Rodrigo A. Munoz +5 more
TL;DR: Diagnostic criteria for 14 psychiatric illnesses along with the validating evidence for these diagnostic categories comes from workers outside the authors' group as well as from those within; it consists of studies of both outpatients and inpatients, of family studies, and of follow-up studies.