Analysis of long non-coding RNA expression profiles in gastric cancer
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TLDR
A set of lncRNAs differentially expressed in gastric cancer is identified, providing useful information for discovery of new biomarkers and therapeutic targets in Gastric cancer.Abstract:
CONCLUSION: We identified a set of lncRNAs differentially expressed in gastric cancer, providing useful information for discovery of new biomarkers and therapeutic targets in gastric cancer.read more
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MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: In this article, a review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
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Revealing protein–lncRNA interaction
TL;DR: The in silico inference methods developed for the accurate computational prediction of the interaction of RBP–lncRNA pairs offer essential clues for a better understanding of lncRNA cellular mechanisms and their disease-associated perturbations.
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P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression
Erbao Zhang,Dandan Yin,Ming Sun,Rong Kong,Xinlu Liu,Lianghui You,Liang Han,Rui Xia,Keming Wang,Jin Song Yang,Wei De,Yongqian Shu,Wang Zibin +12 more
TL;DR: Results suggest that p53-regulated TUG1 is a growth regulator, which acts in part through control of HOXB7, thus participating in AKT and MAPK pathways.
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Long noncoding RNAs: Novel insights into hepatocelluar carcinoma
TL;DR: The regulation and functional role of lncRNAs in HCC is discussed and the potential of lNCRNAs as prospective novel therapeutic targets in H CC is evaluated.
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Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment
Keisuke Katsushima,Atsushi Natsume,Fumiharu Ohka,Fumiharu Ohka,Keiko Shinjo,Akira Hatanaka,Norihisa Ichimura,Shinya Sato,Satoru Takahashi,Hiroshi Kimura,Yasushi Totoki,Tatsuhiro Shibata,Mitsuru Naito,Hyun Jin Kim,Kanjiro Miyata,Kazunori Kataoka,Yutaka Kondo,Yutaka Kondo +17 more
TL;DR: It is found that Notch1 activation in GSCs specifically induces expression of the lncRNA, TUG1, which highlights the importance of the Notch-lncRNA axis in regulating self-renewal of glioma cells and provides a strong rationale for targeting Tug1 as a specific and potent therapeutic approach to eliminate the GSC population.
References
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Journal ArticleDOI
MicroRNAs: Target Recognition and Regulatory Functions
TL;DR: The current understanding of miRNA target recognition in animals is outlined and the widespread impact of miRNAs on both the expression and evolution of protein-coding genes is discussed.
Journal ArticleDOI
BLAST+: architecture and applications.
Christiam Camacho,George Coulouris,Vahram Avagyan,Ning Ma,Jason S. Papadopoulos,Kevin Bealer,Thomas L. Madden +6 more
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Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments
TL;DR: The hierarchical model of Lonnstedt and Speed (2002) is developed into a practical approach for general microarray experiments with arbitrary numbers of treatments and RNA samples and the moderated t-statistic is shown to follow a t-distribution with augmented degrees of freedom.
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Exploration, normalization, and summaries of high density oligonucleotide array probe level data
Rafael A. Irizarry,Bridget G. Hobbs,Francois Collin,Yasmin Beazer-Barclay,Kristen J. Antonellis,Uwe Scherf,Terence P. Speed +6 more
TL;DR: There is no obvious downside to using RMA and attaching a standard error (SE) to this quantity using a linear model which removes probe-specific affinities, and the exploratory data analyses of the probe level data motivate a new summary measure that is a robust multi-array average (RMA) of background-adjusted, normalized, and log-transformed PM values.
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Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
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TL;DR: It is shown that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression, indicating that l incRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.
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