Antiviral Immunity Directed by Small RNAs
Shou-Wei Ding,Olivier Voinnet +1 more
TLDR
The proteins required for viRNA production as well as several key downstream components of the antiviral immunity pathway have been identified in plants, flies, and worms, illuminating an ongoing molecular arms race that likely impacts the evolution of both viral and host genomes.About:
This article is published in Cell.The article was published on 2007-08-10 and is currently open access. It has received 1431 citations till now. The article focuses on the topics: RNA silencing & RNA.read more
Citations
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Journal ArticleDOI
RNA-based antiviral immunity
TL;DR: Recent studies on the features of viral siRNAs and other virus-derived small RNAs from virus-infected fungi, plants, insects, nematodes and vertebrates are reviewed and the innate and adaptive properties of RNA-based antiviral immunity are discussed.
Journal ArticleDOI
RNA interference in Lepidoptera: An overview of successful and unsuccessful studies and implications for experimental design
Olle Terenius,Alexie Papanicolaou,Alexie Papanicolaou,Jennie S. Garbutt,Ioannis Eleftherianos,Hanneke Huvenne,Sriramana Kanginakudru,Merete Albrechtsen,Chunju An,Jean Luc Aymeric,Andrea Barthel,Piotr Bebas,Kavita Bitra,Alejandra Bravo,François Chevalier,Derek Collinge,Derek Collinge,Cristina M. Crava,Ruud A. de Maagd,Bernard Duvic,Martin A. Erlandson,Martin A. Erlandson,Ingrid Faye,G Felfoldi,Haruhiko Fujiwara,Ryo Futahashi,Ryo Futahashi,Archana S. Gandhe,H.S. Gatehouse,L. N. Gatehouse,Jadwiga M. Giebultowicz,Isabel Gómez,Cornelis J. P. Grimmelikhuijzen,Astrid T. Groot,Frank Hauser,David G. Heckel,Dwayne D. Hegedus,Dwayne D. Hegedus,Steven Hrycaj,Lihua Huang,J. Joe Hull,Kostas Iatrou,Masatoshi Iga,Michael R. Kanost,Joanna Kotwica,Changyou Li,Jianghong Li,Jisheng Liu,Magnus Lundmark,Shogo Matsumoto,Martina Meyering-Vos,Peter J. Millichap,Antónia Monteiro,Nirotpal Mrinal,Teruyuki Niimi,Daniela Nowara,Atsushi Ohnishi,Vicencio Oostra,Katsuhisa Ozaki,Maria P. Papakonstantinou,Aleksandar Popadic,Manchikatla Venkat Rajam,Suzanne V. Saenko,Robert M. Simpson,Mario Soberón,Michael R. Strand,Shuichiro Tomita,Umut Toprak,Ping Wang,Choon Wei Wee,Steven Whyard,Wenqing Zhang,Javaregowda Nagaraju,Richard H. ffrench-Constant,Salvador Herrero,Salvador Herrero,Karl H.J. Gordon,Luc Swevers,Guy Smagghe +78 more
TL;DR: Despite a large variation in the data, trends that are found are that RNAi is particularly successful in the family Saturniidae and in genes involved in immunity and that gene expression in epidermal tissues seems to be most difficult to silence.
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On the road to reading the RNA-interference code.
Haruhiko Siomi,Mikiko C. Siomi +1 more
TL;DR: The finding that sequence-specific gene silencing occurs in response to the presence of double-stranded RNAs has had an enormous impact on biology, uncovering an unsuspected level of regulation of gene expression.
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Immunity in Drosophila melanogaster — from microbial recognition to whole-organism physiology
TL;DR: The fruit fly Drosophila melanogaster has been used to understand how the immune response is regulated and coordinated at the level of the whole organism, and recent studies that have explored the effects of organism-wide regulation of theimmune response and, conversely, the effects on organism physiology are highlighted.
Journal ArticleDOI
Viruses, microRNAs, and host interactions.
TL;DR: The current knowledge of viral miRNAs and virally influenced cellular mi RNAs and their relationship to viral infection is discussed.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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The plant immune system
TL;DR: A detailed understanding of plant immune function will underpin crop improvement for food, fibre and biofuels production and provide extraordinary insights into molecular recognition, cell biology and evolution across biological kingdoms.
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Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
TL;DR: It is shown that the sequestration of miR-122 in liver cells results in marked loss of autonomously replicating hepatitis C viral RNAs, suggesting that miR -122 may present a target for antiviral intervention.
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A Plant miRNA Contributes to Antibacterial Resistance by Repressing Auxin Signaling
Lionel Navarro,Patrice Dunoyer,Florence Jay,Benedict Arnold,Nihal Dharmasiri,Mark Estelle,Olivier Voinnet,Jonathan D. G. Jones +7 more
TL;DR: It is shown that a flagellin-derived peptide induces a plant microRNA (miRNA) that negatively regulates messenger RNAs for the F-box auxin receptors TIR1, AFB2, and AFB3, implicating auxin in disease susceptibility and miRNA-mediated suppression of auxin signaling in resistance.
Journal ArticleDOI
Identification of Virus-Encoded MicroRNAs
Sébastien Pfeffer,Mihaela Zavolan,Friedrich A. Grässer,Minchen Chien,James J. Russo,Jingyue Ju,Bino John,Anton J. Enright,Debora S. Marks,Chris Sander,Thomas Tuschl +10 more
TL;DR: The small RNA profile of cells infected by Epstein-Barr virus is recorded and it is shown that EBV expresses several microRNA (miRNA) genes, which are identified viral regulators of host and/or viral gene expression.