Journal ArticleDOI
Arsenic trioxide induces apoptosis and G2/M phase arrest by inducing Cbl to inhibit PI3K/Akt signaling and thereby regulate p53 activation.
Ying-Chun Li,Xiujuan Qu,Jinglei Qu,Ye Zhang,Jing Liu,Yuee Teng,Xuejun Hu,Kezuo Hou,Yunpeng Liu +8 more
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TLDR
It is demonstrated that inhibition of PI3K/Akt signaling by Cbl is involved in both ATO-induced apoptosis of NB4 cells and ATo-induced G2/M phase arrest of gastric cancer cells.About:
This article is published in Cancer Letters.The article was published on 2009-11-01. It has received 76 citations till now. The article focuses on the topics: PI3K/AKT/mTOR pathway & Protein kinase B.read more
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Arsenic-induced oxidative stress and its reversibility
TL;DR: This review summarizes the literature describing the molecular mechanisms of arsenic-induced oxidative stress, its relevant biomarkers, and its relation to various diseases, including preventive and therapeutic strategies and updates the reader on recent advances in chelation therapy and newer therapeutic strategies suggested to treat arsenic- induced oxidative damage.
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LncRNA AK023391 promotes tumorigenesis and invasion of gastric cancer through activation of the PI3K/Akt signaling pathway
TL;DR: The novel oncogenic lncRNA AK023391 in gastric cancer exerts its effects through activation of the PI3K/Akt signaling pathway, and may act as a potential biomarker for survival in patients with Gastric cancer.
Journal ArticleDOI
Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic
Hai nan Zhang,Lina Yang,Jianya Ling,Daniel M. Czajkowsky,Jingfang Wang,Xiaowei Zhang,Yi Ming Zhou,Feng Ge,Ming Kun Yang,Qian Xiong,Shu Juan Guo,Huang Ying Le,Song Fang Wu,Wei Yan,Bingya Liu,Heng Zhu,Zhu Chen,Sheng-Ce Tao +17 more
TL;DR: In-depth in vitro and in vivo analysis revealed that gly colysis in general and the rate-limiting enzyme hexokinase-2 of the glycolytic pathway in particular play a key role in mediating the anticancer activity of arsenic.
Journal ArticleDOI
As4S4 targets RING-type E3 ligase c-CBL to induce degradation of BCR-ABL in chronic myelogenous leukemia
Jian-Hua Mao,Xiao-Yan Sun,Jian-Xiang Liu,Qun-Ye Zhang,Ping Liu,Qiu-Hua Huang,Keqin Kathy Li,Quan Chen,Zhu Chen,Sai Juan Chen +9 more
TL;DR: In conclusion, arsenic directly bound the RING finger domain of c-CBL to inhibit its self-ubiquitination/degradation without interfering with the enhancement of ubiquitination and subsequent proteolysis of its substrate BCR-ABL.
Journal ArticleDOI
Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors
Zhifen Cui,Yu Zhang,Kai Xia,Qinglong Yan,Huating Kong,Jichao Zhang,Xiaolei Zuo,Jiye Shi,Jiye Shi,Lihua Wang,Lihua Wang,Ying Zhu,Chunhai Fan,Chunhai Fan +13 more
TL;DR: It is found that NDs and ATO are physically separate and functionally target different cellular pathways (autophagy vs. apoptosis); whereas their metabolic coupling in human liver carcinoma cells remarkably enhances programmed cell death.
References
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Journal ArticleDOI
Surfing the p53 network
TL;DR: The p53 tumour-suppressor gene integrates numerous signals that control cell life and death, and the disruption of p53 has severe consequences when a highly connected node in the Internet breaks down.
Journal ArticleDOI
p53 in health and disease.
Karen H. Vousden,David P. Lane +1 more
TL;DR: It is now becoming clear that p53 can have a much broader role and can contribute to the development, life expectancy and overall fitness of an organism.
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In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins
Guo-Qiang Chen,Jun Zhu,Xue-Geng Shi,Jian-Hua Ni,Hao-Jie Zhong,Gui-Ying Si,Xiao-Long Jin,Wei Tang,Xiu-Shong Li,Shu-Ming Xong,Zhi-Xiang Shen,Guan-Lin Sun,Jun Ma,Peng Zhang,Ting-Dong Zhang,Claude Gazin,Tomoki Naoe,Sai-Juan Chen,Zhen-Yi Wang,Zhu Chen +19 more
TL;DR: In this paper, As2O3 was shown to trigger NB4 cell apoptosis at micromolar concentration, as proved by morphology, histogramic related nuclear DNA contents, and DNA gel eletrophoresis.
Journal ArticleDOI
Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53 *
Yoko Ogawara,Shohei Kishishita,Toshiyuki Obata,Yuko Isazawa,Toshiaki Suzuki,Keiji Tanaka,Norihisa Masuyama,Yukiko Gotoh,Yukiko Gotoh +8 more
TL;DR: It is suggested that Akt enhances the ubiquitination-promoting function of Mdm2 by phosphorylation of Ser186, which results in reduction of p53 protein.
Journal ArticleDOI
PKB binding proteins. Getting in on the Akt.
TL;DR: In this article, the implications of these data in understanding the multitude of functions predicted for PKB in cells are discussed, and a review of the literature can be found in Section 2.