Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Peter Horby,Marion K Campbell,Enti Spata,Jonathan Emberson,Natalie Staplin,Guilherme Pessoa-Amorim,Leon Peto,Martin Wiselka,L Wiffen,Simon Tiberi,B Caplin,C Wroe,Carole Green,Paul Hine,B Prudon,T George,A Wight,J K Baillie,Buddha Basnyat,Maya H Buch,Lucy C Chappell,Jeremy N. Day,Saul N. Faust,Raph L. Hamers,Thomas Jaki,Edmund Juszczak,Katie Jeffery,Wei Shen Lim,Alan A Montgomery,Andrew D Mumford,Kathy Rowan,G Thwaites,M Mafham,Richard Haynes,Martin J Landray +34 more
TLDR
In this paper, the authors evaluated the effects ofcilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation, and found that the drug improved survival and other clinical outcomes.About:
This article is published in The Lancet.The article was published on 2021-02-13 and is currently open access. It has received 474 citations till now. The article focuses on the topics: Tocilizumab & Population.read more
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A living WHO guideline on drugs for covid-19
Bram Rochwerg,Arnav Agarwal,Reed A C Siemieniuk,Thomas Agoritsas,Francois Lamontagne,Lisa Askie,Lyubov Lytvyn,Yee Sin Leo,Helen Macdonald,Linan Zeng,Wagdy Amin,Erlina Burhan,Frédérique Jacquerioz Bausch,Carolyn S. Calfee,Maurizio Cecconi,Duncan Chanda,Bin Du,Heike Geduld,Patrick Gee,Nerina Harley,Madiha Hashimi,Beverly Hunt,Sushil K. Kabra,Seema Kanda,Leticia Kawano-Dourado,Yae-Jean Kim,Niranjan Kissoon,Arthur Kwizera,Imelda Mahaka,Hela Manai,Greta Mino,Emmanuel Nsutebu,Jacobus Preller,Natalia Pshenichnaya,Nida Qadir,Saniya Sabzwari,Rohit Sarin,Manu Shankar-Hari,Mike Sharland,Yinzhong Shen,Shalini Sri Ranganathan,João Paulo Souza,Miriam Stegemann,An De Sutter,Sebastian Ugarte,Sridhar Venkatapuram,Vu Quoc Dat,Dubula Vuyiseka,Ananda Wijewickrama,Brittany J. Maguire,Dena Zeraatkar,Jessica J Bartoszko,Long Ge,Long Ge,Romina Brignardello-Petersen,Andrew Owen,Gordon H. Guyatt,Janet V. Diaz,Michael Jacobs,Per Olav Vandvik +59 more
TL;DR: A standing international panel of content experts, patients, clinicians, and methodologists, free from relevant conflicts of interest, produce recommendations for clinical practice, containing a strong recommendation for systemic corticosteroids in patients with severe and critical covid-19, and a weak or conditional recommendation against systemic cortiosteroids for non-severe patients.
Journal ArticleDOI
Drug treatments for covid-19: living systematic review and network meta-analysis.
Reed A C Siemieniuk,Jessica J Bartoszko,Long Ge,Dena Zeraatkar,Ariel Izcovich,Elena Kum,Hector Pardo-Hernandez,Anila Qasim,Juan Pablo Diaz Martinez,Bram Rochwerg,Francois Lamontagne,Mi Ah Han,Qin Liu,Arnav Agarwal,Arnav Agarwal,Thomas Agoritsas,Derek K. Chu,Rachel Couban,Ellen Cusano,Andrea Darzi,Tahira Devji,Bo Fang,Carmen Fang,Signe Flottorp,Signe Flottorp,Farid Foroutan,Farid Foroutan,Maryam Ghadimi,Diane Heels-Ansdell,Kimia Honarmand,Liangying Hou,Xiaorong Hou,Quazi Ibrahim,Assem M. Khamis,Bonnie Lam,Mark Loeb,Maura Marcucci,Shelley McLeod,Sharhzad Motaghi,Srinivas Murthy,Reem A. Mustafa,Reem A. Mustafa,John Neary,Gabriel Rada,Irbaz Bin Riaz,Behnam Sadeghirad,Nigar Sekercioglu,Lulu Sheng,Ashwini Sreekanta,Charlotte Switzer,Britta Tendal,Lehana Thabane,George Tomlinson,Tari Turner,Per Olav Vandvik,Robin W.M. Vernooij,Andrés Viteri-García,Ying Wang,Liang Yao,Zhikang Ye,Gordon H Guyatt,Romina Brignardello-Petersen +61 more
TL;DR: Glucocorticoids probably reduce mortality and mechanical ventilation in patients with covid-19 compared with standard care and the effectiveness of most interventions is uncertain because most of the randomised controlled trials so far have been small and have important study limitations.
Journal ArticleDOI
Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis.
Manu Shankar-Hari,Claire L Vale,Peter J. Godolphin,David Fisher,Higgins Jpt.,Francesca Spiga,Jelena Savović,Jelena Savović,Jayne F. Tierney,Gabriel Baron,Julie Benbenishty,Lindsay R. Berry,N Broman,Alexandre Biasi Cavalcanti,R Colman,S. De Buyser,Derde Lpg.,P Domingo,S F Omar,A Fernandez-Cruz,T Feuth,F Garcia,R Garcia-Vicuna,I Gonzalez-Alvaro,Anthony C. Gordon,Richard Haynes,Olivier Hermine,Peter Horby,Nora Horick,K Kumar,B N Lambrecht,Martin J Landray,L Leal,D J Lederer,Elizabeth Lorenzi,X Mariette,N Merchante,N A Misnan,S V Mohan,M C Nivens,J Oksi,J A Perez-Molina,R Pizov,R Porcher,S Postma,R Rajasuriar,Athimalaipet V Ramanan,P Ravaud,Pankti Reid,Abraham Rutgers,A Sancho-Lopez,Todd B. Seto,S Sivapalasingam,A S Soin,Natalie Staplin,John H. Stone,Garth W. Strohbehn,J Sunden-Cullberg,J Torre-Cisneros,L W Tsai,H. van Hoogstraten,T. van Meerten,Viviane C Veiga,P E Westerweel,Srinivas Murthy,Janet V. Diaz,John C. Marshall,Sterne Jac. +67 more
TL;DR: In this article, a prospective meta-analysis of clinical trials of patients hospitalized for COVID-19, administration of IL-6 antagonists, compared with usual care or placebo, was associated with lower 28-day all-cause mortality.
Journal ArticleDOI
Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial
Martin J Landray,Peter Horby,Jonathan Emberson,Natalie Staplin,Enti Spata,Guilherme Pessoa-Amorim,Leon Peto,M Mafham,Richard Haynes +8 more
TL;DR: In this article, the authors evaluated the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19 and found no significant difference in 28-day mortality between the two groups.
Journal ArticleDOI
Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebo-controlled phase 3 trial.
Vincent C. Marconi,Vincent C. Marconi,Athimalaipet V Ramanan,Stephanie de Bono,Cynthia E. Kartman,Venkatesh Krishnan,Ran Liao,Maria Lucia B. Piruzeli,Jason D Goldman,Jorge Alatorre-Alexander,Rita de Cassia Pellegrini,Vicente Estrada,Mousumi Som,Anabela Cardoso,Sujatro Chakladar,Brenda J. Crowe,Paulo Reis,Xin Zhang,David H. Adams,E. Wesley Ely +19 more
TL;DR: Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-inflammatory properties as discussed by the authors, which has been shown to reduce mortality in hospitalised adults with COVID-19.
References
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Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
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Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
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Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients
TL;DR: Aspirin (or another oral antiplatelet drug) is protective in most types of patient at increased risk of occlusive vascular events, including those with an acute myocardial infarction or ischaemic stroke, unstable or stable angina, previous myocardian infarctions, stroke or cerebral ischaemia, peripheral arterial disease, or atrial fibrillation.
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Endothelial cell infection and endotheliitis in COVID-19.
Zsuzsanna Varga,Andreas J. Flammer,Peter Steiger,Martina Haberecker,Rea Andermatt,Annelies S. Zinkernagel,Mandeep R. Mehra,Reto A. Schuepbach,Frank Ruschitzka,Holger Moch +9 more
TL;DR: The vascular endothelium is an active paracrine, endocrine, and Endothelial cell infection and endotheliitis in COVID-19 and recruitment of immune cells can result in widespread endothelial dysfunction associated with apoptosis.
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Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
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Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis.
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