Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.
Hongchao Pan,Richard Peto,Ana-Maria Henao-Restrepo,Marie-Pierre Preziosi,Vasee Sathiyamoorthy,Quarraisha Abdool Karim,Marissa M. Alejandria,César Hernández García,Marie-Paule Kieny,Reza Malekzadeh,Srinivas Murthy,K. Srinath Reddy,Mirta Roses Periago,Pierre Abi Hanna,Florence Ader,Abdullah M. Al-Bader,Almonther Alhasawi,Emma Allum,Athari Alotaibi,Carlos A Alvarez-Moreno,Sheila Appadoo,Abdullah Asiri,Pål Aukrust,Andreas Barratt-Due,Samir Bellani,Mattia Branca,Heike B. C. Cappel-Porter,Nery Cerrato,Ting S. Chow,Najada Como,Joseph A. Eustace,Patricia J. Garcia,Sheela Godbole,Eduardo Gotuzzo,Laimonas Griskevicius,Rasha Hamra,Mariam Hassan,Mohamed Hassany,David Hutton,Irmansyah Irmansyah,Ligita Jancoriene,Jana Kirwan,Suresh Kumar,Peter Lennon,Gustavo Lopardo,Patrick Lydon,Nicola Magrini,Teresa Maguire,Suzana Manevska,Oriol Manuel,Sibylle McGinty,Marco T. Medina,María L. Mesa Rubio,Maria C. Miranda-Montoya,Jeremy Nel,Estevão Portela Nunes,Markus Perola,Antonio Portolés,Menaldi R. Rasmin,Aun Raza,Helen Rees,Paula P. S. Reges,Chris A Rogers,Kolawole Salami,Marina I. Salvadori,Narvina Sinani,Jonathan A C Sterne,Milena Stevanovikj,Evelina Tacconelli,Kari A.O. Tikkinen,Sven Trelle,Hala Zaid,John-Arne Røttingen,Soumya Swaminathan +73 more
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These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital stay.Abstract:
Background World Health Organization expert groups recommended mortality trials of four repurposed antiviral drugs - remdesivir, hydroxychloroquine, lopinavir, and interferon beta-1a - in patients hospitalized with coronavirus disease 2019 (Covid-19). Methods We randomly assigned inpatients with Covid-19 equally between one of the trial drug regimens that was locally available and open control (up to five options, four active and the local standard of care). The intention-to-treat primary analyses examined in-hospital mortality in the four pairwise comparisons of each trial drug and its control (drug available but patient assigned to the same care without that drug). Rate ratios for death were calculated with stratification according to age and status regarding mechanical ventilation at trial entry. Results At 405 hospitals in 30 countries, 11,330 adults underwent randomization; 2750 were assigned to receive remdesivir, 954 to hydroxychloroquine, 1411 to lopinavir (without interferon), 2063 to interferon (including 651 to interferon plus lopinavir), and 4088 to no trial drug. Adherence was 94 to 96% midway through treatment, with 2 to 6% crossover. In total, 1253 deaths were reported (median day of death, day 8; interquartile range, 4 to 14). The Kaplan-Meier 28-day mortality was 11.8% (39.0% if the patient was already receiving ventilation at randomization and 9.5% otherwise). Death occurred in 301 of 2743 patients receiving remdesivir and in 303 of 2708 receiving its control (rate ratio, 0.95; 95% confidence interval [CI], 0.81 to 1.11; P = 0.50), in 104 of 947 patients receiving hydroxychloroquine and in 84 of 906 receiving its control (rate ratio, 1.19; 95% CI, 0.89 to 1.59; P = 0.23), in 148 of 1399 patients receiving lopinavir and in 146 of 1372 receiving its control (rate ratio, 1.00; 95% CI, 0.79 to 1.25; P = 0.97), and in 243 of 2050 patients receiving interferon and in 216 of 2050 receiving its control (rate ratio, 1.16; 95% CI, 0.96 to 1.39; P = 0.11). No drug definitely reduced mortality, overall or in any subgroup, or reduced initiation of ventilation or hospitalization duration. Conclusions These remdesivir, hydroxychloroquine, lopinavir, and interferon regimens had little or no effect on hospitalized patients with Covid-19, as indicated by overall mortality, initiation of ventilation, and duration of hospital stay. (Funded by the World Health Organization; ISRCTN Registry number, ISRCTN83971151; ClinicalTrials.gov number, NCT04315948.).read more
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Severe Covid-19
TL;DR: Key Clinical Points Evaluation and Management of Severe Covid-19 Patients with severe coronavirus disease 2019 (Covid- 19) may become critically ill with acute respiratory distress syndrome that typ...
Journal ArticleDOI
Genetic mechanisms of critical illness in Covid-19.
Erola Pairo-Castineira,Erola Pairo-Castineira,Sara Clohisey,Lucija Klaric,Andrew D. Bretherick,Konrad Rawlik,Dorota Pasko,Susan P. Walker,Nicholas J. Parkinson,Max Head Fourman,Clark D Russell,James J Furniss,Anne Richmond,E. Gountouna,Nicola Wrobel,David A Harrison,B. Wang,Yang Wu,A. Meynert,Fiona Griffiths,Wilna Oosthuyzen,Athanasios Kousathanas,Loukas Moutsianas,Z. Yang,R. Zhai,Canbin Zheng,Graeme R. Grimes,Rupert Beale,Jonathan E Millar,Barbara Shih,Seán Keating,Marie Zechner,Chris Haley,David J. Porteous,Caroline Hayward,Jian Yang,Julian C. Knight,Charlotte Summers,Manu Shankar-Hari,Manu Shankar-Hari,Paul Klenerman,Lance Turtle,Antonia Ho,S. C. Moore,Charles J. Hinds,P. Horby,Alistair Nichol,Alistair Nichol,Alistair Nichol,David M. Maslove,Lowell Ling,Daniel F. McAuley,Hugh Montgomery,Timothy S. Walsh,Alexandre C. Pereira,Alessandra Renieri,C. Ponting,J. Meikle,P. Finernan,E. Mcmaster,E. Mcmaster,Andy Law,J. K. Baillie,T. Paterson,T. Wackett,Robert C. Armstrong,Robert C. 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Cooper,Anthony Evans,W. Khaliq,Andrea M. Collins,E. T. Gude,N. Love,L. van Koutrik,John A. Hunt,D. Kaye,Eva Fisher,A. Brayne,V. Tuckey,P. Jackson,J. Parkin,A. Tariq,Henry Houlden,A. Tucci,John Hardy,E. Moncur,J. Highgate,A. Cowley,A. Mitra,R. Stead,T. Behan,C. Burnett,M. Newton,E. Heeney,R. Pollard,J. Hatton,Amita Patel,Vidya Kasipandian,S. Allibone,R. M. Genetu,L. O'Brien,Z. Omar,E. Perkins,Kevin A. Davies,D. Tetla,B. Shelley,V. Irvine,Samantha J. Williams,Patricia Williams,J. Goodsell,R. Tutton,L. Bough,B. Winter-Goodwin,R. Kitson,J. Pinnell,Anthony J. Wilson,T. Nortcliffe,T. Wood,M. Home,K. Holdroyd,Matthew R. Robinson,R. Shaw,J. Greig,M. Brady,A. Haigh,L. Matupe,M. Usher,S. Mellor,S. Dale,L. Gledhill,L. Shaw,G. Turner,Donna Kelly,B. Anwar,Heather L. Riley,H. Sturgeon,A. Ali,L. Thomis,D. Melia,A. Dance,SE Humphreys,I. Frost,V. Gopal,Jo Godden,A. Holden,S. Swann,Tony Smith,M. Clapham,U. Poultney,R. Harper,P. Rice,R. Reece-Anthony,B. Gurung,S. Moultrie,M. Odam,Andreas Mayer,A. Bellini,A. Pickard,J. Bryant,N. Roe,J. Sowter,K. Lang,Jenny C. Taylor,P. Barry,Maria Hobrok,H. Tench,R. Wolf-Roberts,H. McGuinness,R. Loosley,Daniel B Hawcutt,L. Rad,L. O'Malley,P. Saunderson,G. Seddon,Tim J. Anderson,N. Rogers,J. Ruddy,M. Harkins,C. Beith,A. McAlpine,L. Ferguson,Paul Grant,S. MacFadyen,M. McLaughlin,T. Baird,S. Rundell,B. Welsh,R. Hamill,F. Fisher,J. Gregory,Campbell A,S. Smuts,J Kenneth Baillie,J Kenneth Baillie,Gail Carson,Beatrice Alex,B. Bach,Wendy S. Barclay,Debby Bogaert,Meera Chand,Graham S Cooke,Annemarie B Docherty,Jake Dunning,A. da Silva Filipe,Tom Fletcher,Christopher A Green,Ewen M Harrison,Julian A. Hiscox,Ho A. Y. W.,Peter Horby,Samreen Ijaz,S. Khoo,W. S. Lim,Alexander J. Mentzer,Laura Merson,Alison M. Meynert,Mahdad Noursadeghi,Massimo Palmarini,William A. Paxton,Georgios Pollakis,Nicholas Price,Andrew Rambaut,David Robertson,Vanessa Sancho-Shimizu,Janet T Scott,T I de Silva,Louise Sigfrid,Tom Solomon,Shiranee Sriskandan,David I. Stuart,R.S. Tedder,E. Thomson,Alfred A.R. Thompson,Ryan S Thwaites,L Turtle,Maria Zambon,Hayley Hardwick,Chloe Donohue,Ronan A Lyons,Lisa Norman,Riinu Pius,Thomas M Drake,Cameron J Fairfield,Stephen R Knight,Kenneth A. McLean,Derek Murphy,C. A. Shaw,Jo Dalton,Michelle Girvan,Egle Saviciute,Stuart K. Roberts,Janet Harrison,Laura Marsh,Marie Connor,Sophie Halpin,Carrol Gamble,Gary Leeming,Murray Wham,William Greenhalf,V. Shaw,Sarah D. McDonald,Andrea Ganna,Patrick Sulem,D A van Heel,M. Cordioli,Gardar Sveinbjornsson,M. E. K. Niemi,Janie F. Shelton,A. J. Shastri,C. Ye,C. H. Weldon,T. Filshtein-Sonmez,D. Coker,A. Symons,J. Esparza-Gordillo,Stella Aslibekyan,Adam Auton,J. E. Krieger,E. Marques,C. E. Jannes,Francesca Mari,S. Daga,Margherita Baldassarri,Elisa Benetti,Simone Furini,Chiara Fallerini,Francesca Fava,Floriana Valentino,G. Doddato,Annarita Giliberti,Rossella Tita,Sara Amitrano,Mirella Bruttini,S. Croci,I. Meloni,A. M. Pinto,E. Frullanti,Maria Antonietta Mencarelli,C. L. Rizzo,Francesca Montagnani,L. Di Sarno,A. Tommasi,Marta Palmieri,Arianna Emiliozzi,M. Fabbiani,Barbara Rossetti,Giacomo Zanelli,Elena Bargagli,Laura Bergantini,Miriana d'Alessandro,Paolo Cameli,D. Bennet,Federico Anedda,Simona Marcantonio,Sabino Scolletta,Federico Franchi,Maria Antonietta Mazzei,S. Guerrini,Edoardo Conticini,Luca Cantarini,Bruno Frediani,D. Tacconi,C. Spertilli,M. Feri,Abele Donati,R. Scala,L. Guidelli,G. Spargi,M. Corridi,C. Nencioni,L. Croci,G. P. Caldarelli,M. Spagnesi,P. Piacentini,M. Bandini,E. Desanctis,S. Cappelli,A. Canaccini,A. Verzuri,V. Anemoli,A. Ognibene,M. Vaghi,A d'Arminio Monforte,Esther Merlini,M. U. Mondelli,S. Mantovani,S. Ludovisi,Massimo Girardis,S. Venturelli,M. Sita,Andrea Cossarizza,A. Antinori,Alessandra Vergori,Stefano Rusconi,M. Siano,A. Gabrieli,Agostino Riva,Daniela Francisci,Elisabetta Schiaroli,P. G. Scotton,F. Andretta,S. Panese,R. Scaggiante,F. Gatti,S. G. Parisi,Francesco Castelli,M. E. Quiros-Roldan,P. Magro,Isabella Zanella,M. Della Monica,Carmelo Piscopo,Mario Capasso,Roberta Russo,Immacolata Andolfo,Achille Iolascon,G. Fiorentino,M. Carella,Marco Castori,Giuseppe Merla,Filippo Aucella,P. Raggi,C. Marciano,R. Perna,Matteo Bassetti,A. Di Biagio,M. Sanguinetti,L. Masucci,Serafina Valente,Marco Mandalà,A. Giorli,L. Salerni,P. Zucchi,P. Parravicini,E. Menatti,S. Baratti,T. Trotta,F. Giannattasio,G. Coiro,F. Lena,D. A. Coviello,Cristina Mussini,G. Bosio,E. Martinelli,Sandro Mancarella,L. Tavecchia,L. Crotti,N. Picchiotti,M. Gori,C. Gabbi,M. Sanarico,S. Ceri,P. Pinoli,F. Raimondi,F. Biscarini,A. Stella,Xia Shen,Xia Shen,Chris P. Ponting,Angie Fawkes,Albert Tenesa,Albert Tenesa,Mark J. Caulfield,Richard H Scott,K Rowan,Lee Murphy,Peter J. M. Openshaw,Peter J. M. Openshaw,Malcolm G Semple,Veronique Vitart,James F. Wilson +1449 more
TL;DR: The GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2244 critically ill Covid-19 patients from 208 UK intensive care units is reported, finding evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease.
Posted ContentDOI
An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Dafydd R. Owen,Charlotte Moira Norfor Allerton,Annaliesa S. Anderson,Lisa Aschenbrenner,Melissa Avery,Simon Berritt,Britton Boras,Rhonda D. Cardin,Anthony Carlo,Karen J. Coffman,Alyssa Dantonio,Li Di,Heather Eng,RoseAnn Ferre,Ketan S. Gajiwala,Scott A. Gibson,Samantha Elizabeth Greasley,Brett L. Hurst,Eugene P. Kadar,Amit S. Kalgutkar,Jack C. Lee,Jisun Lee,Wei Liu,Stephen W. Mason,Stephen Noell,Jonathan J. Novak,R. Scott Obach,Kevin Ogilvie,Nandini Chaturbhai Patel,Martin Pettersson,Devendra K. Rai,Matthew R. Reese,Matthew F. Sammons,Jean G. Sathish,Ravi Shankar P. Singh,Claire M. Steppan,Al E. Stewart,Jamison B. Tuttle,Lawrence W. Updyke,Patrick Robert Verhoest,Liuqing Wei,Qingyi Yang,Yuao Zhu +42 more
TL;DR: The worldwide outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome (SARS-CoV-2) has become a global pandemic as discussed by the authors.
Journal ArticleDOI
A living WHO guideline on drugs for covid-19
Bram Rochwerg,Arnav Agarwal,Reed A C Siemieniuk,Thomas Agoritsas,Francois Lamontagne,Lisa Askie,Lyubov Lytvyn,Yee Sin Leo,Helen Macdonald,Linan Zeng,Wagdy Amin,Erlina Burhan,Frédérique Jacquerioz Bausch,Carolyn S. Calfee,Maurizio Cecconi,Duncan Chanda,Bin Du,Heike Geduld,Patrick Gee,Nerina Harley,Madiha Hashimi,Beverly Hunt,Sushil K. Kabra,Seema Kanda,Leticia Kawano-Dourado,Yae-Jean Kim,Niranjan Kissoon,Arthur Kwizera,Imelda Mahaka,Hela Manai,Greta Mino,Emmanuel Nsutebu,Jacobus Preller,Natalia Pshenichnaya,Nida Qadir,Saniya Sabzwari,Rohit Sarin,Manu Shankar-Hari,Mike Sharland,Yinzhong Shen,Shalini Sri Ranganathan,João Paulo Souza,Miriam Stegemann,An De Sutter,Sebastian Ugarte,Sridhar Venkatapuram,Vu Quoc Dat,Dubula Vuyiseka,Ananda Wijewickrama,Brittany J. Maguire,Dena Zeraatkar,Jessica J Bartoszko,Long Ge,Long Ge,Romina Brignardello-Petersen,Andrew Owen,Gordon H. Guyatt,Janet V. Diaz,Michael Jacobs,Per Olav Vandvik +59 more
TL;DR: A standing international panel of content experts, patients, clinicians, and methodologists, free from relevant conflicts of interest, produce recommendations for clinical practice, containing a strong recommendation for systemic corticosteroids in patients with severe and critical covid-19, and a weak or conditional recommendation against systemic cortiosteroids for non-severe patients.
Journal ArticleDOI
Drug treatments for covid-19: living systematic review and network meta-analysis.
Reed A C Siemieniuk,Jessica J Bartoszko,Long Ge,Dena Zeraatkar,Ariel Izcovich,Elena Kum,Hector Pardo-Hernandez,Anila Qasim,Juan Pablo Diaz Martinez,Bram Rochwerg,Francois Lamontagne,Mi Ah Han,Qin Liu,Arnav Agarwal,Arnav Agarwal,Thomas Agoritsas,Derek K. Chu,Rachel Couban,Ellen Cusano,Andrea Darzi,Tahira Devji,Bo Fang,Carmen Fang,Signe Flottorp,Signe Flottorp,Farid Foroutan,Farid Foroutan,Maryam Ghadimi,Diane Heels-Ansdell,Kimia Honarmand,Liangying Hou,Xiaorong Hou,Quazi Ibrahim,Assem M. Khamis,Bonnie Lam,Mark Loeb,Maura Marcucci,Shelley McLeod,Sharhzad Motaghi,Srinivas Murthy,Reem A. Mustafa,Reem A. Mustafa,John Neary,Gabriel Rada,Irbaz Bin Riaz,Behnam Sadeghirad,Nigar Sekercioglu,Lulu Sheng,Ashwini Sreekanta,Charlotte Switzer,Britta Tendal,Lehana Thabane,George Tomlinson,Tari Turner,Per Olav Vandvik,Robin W.M. Vernooij,Andrés Viteri-García,Ying Wang,Liang Yao,Zhikang Ye,Gordon H Guyatt,Romina Brignardello-Petersen +61 more
TL;DR: Glucocorticoids probably reduce mortality and mechanical ventilation in patients with covid-19 compared with standard care and the effectiveness of most interventions is uncertain because most of the randomised controlled trials so far have been small and have important study limitations.
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Varhaug,S. Gundersen,Martin Hauer-Jensen,H. Host,R. Nissen-Meyer,Roger W. Blamey,A. Mitchell,Morgan Da,J.F.R. Robertson,M. Di Palma,G. Mathe,J. L. Misset,R. M. Clark,Mitch Levine,K Morimoto,Y. Takatsuka,E. Crossley,Al Harris,Denis Talbot,Mark Taylor,B. di Blasio,V. Ivanov,Vladimir Semiglazov,J. Brockschmidt,M. R. Cooper,H. Ueo,Carla I. Falkson,Roger A'Hern,Stanley W. Ashley,T. J. Powles,Ian E. Smith,John Yarnold,J.-C. Gazet,N. Cocoran,N. Deshpande,L. di Martino,P. Douglas,A. Lindtner,G Notter,A. J. S. Bryant,G. H. Ewing,L. A. Firth,J. L. Krushen-Kosloski,L. Foster,W.D. George,Helen J. Stewart,P. Stroner,Per-Uno Malmström,Torgil Möller,Stefan Rydén,Ingrid Tengrup,Lena Tennvall-Nittby,J. Carstenssen,M. Dufmats,Thomas Hatschek,Bo Nordenskjöld,Martin Söderberg,John T. Carpenter,KS Albain,J. Crowley,Stuart A. Green,Silvana Martino,CK Osborne,Peter M. Ravdin,U. Glas,Ulla Johansson,L E Rutqvist,T. Singnomklao,Arne Wallgren,Rudolf Maibach,Beat Thürlimann,Hermann Brenner,A. Hercbergs,M Yoshimoto,Gerrit DeBoer,Alexander H.G. Paterson,JW Meakin,T. Panzarella,Y. Shan,Y. F. Shao,X. Wang,D. B. Zhao,Z. M. Chen,H. C. Pan,J. Bahi,M. Reid,M. Spittle,G. P. Deutsch,F. Senanayake,D. L. W. Kwong,Angelo Raffaele Bianco,Chiara Carlomagno,M. De Laurentiis,S. De Placido,Aman U. Buzdar,Tae C Smith,Jonas Bergh,Lars Holmberg,Göran Liljegren,Jan Nilsson,M. Seifert,P. Sevelda,C. C. Zielinsky,R. B. Buchanan,M. Cross,G.T. Royle,Janet A. Dunn,Robert Kerrin Hills,Michael Lee,J. M. Morrison,D. Spooner,A. Litton,Rowan T. Chlebowski,H. Caffier +412 more
TL;DR: The 10-year and 15-year effects of various systemic adjuvant therapies on breast cancer recurrence and survival are reported and it is found that the cumulative reduction in mortality is more than twice as big at 15 years as at 5 years after diagnosis.
Journal ArticleDOI
Remdesivir for the Treatment of Covid-19 - Final Report.
John H. Beigel,Kay M. Tomashek,Lori E. Dodd,Aneesh K. Mehta,Barry S. Zingman,Andre C. Kalil,Elizabeth L. Hohmann,Helen Y. Chu,Annie Luetkemeyer,Susan Kline,Diego Lopez de Castilla,Robert W. Finberg,Kerry Dierberg,Victor F. Tapson,Lanny Hsieh,Thomas F. Patterson,Roger Paredes,Daniel A. Sweeney,William R. Short,Giota Touloumi,David Chien Lye,Norio Ohmagari,Myoung-don Oh,Guillermo M. Ruiz-Palacios,Thomas Benfield,Gerd Fätkenheuer,Mark G. Kortepeter,Robert L. Atmar,C. Buddy Creech,JD Lundgren,Abdel G. Babiker,Sarah Pett,James D. Neaton,Timothy Burgess,Tyler Bonnett,Michelle Green,Mat Makowski,Anu Osinusi,Seema U Nayak,H. Clifford Lane +39 more
TL;DR: The data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.
Journal ArticleDOI
Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
Journal ArticleDOI
A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19.
Bin Cao,Yeming Wang,Danning Wen,Wen Liu,Jingli Wang,Guohui Fan,Lianguo Ruan,Bin Song,Yanping Cai,Ming Wei,Xingwang Li,Jia'an Xia,Nanshan Chen,Jie Xiang,Ting Yu,Tao Bai,Xuelei Xie,Li Zhang,Caihong Li,Ye Yuan,Hua Chen,Huadong Li,Hanping Huang,Shengjing Tu,Fengyun Gong,Ying Liu,Yuan Wei,Chongya Dong,Fei Zhou,Xiaoying Gu,Jiuyang Xu,Zhibo Liu,Yi Zhang,Li Hui,Lianhan Shang,Ke Wang,Kunxia Li,Xia Zhou,Xuan Dong,Zhaohui Qu,Sixia Lu,Xujuan Hu,Shunan Ruan,Shanshan Luo,Jing Wu,Lu Peng,Fang Cheng,Lihong Pan,Jun Zou,Chunmin Jia,Juan Wang,Xia Liu,Shuzhen Wang,Xudong Wu,Qin Ge,Jing He,Haiyan Zhan,Fang Qiu,Li Guo,Chaolin Huang,Thomas Jaki,Frederick G. Hayden,Peter Horby,Dingyu Zhang,Chen Wang +64 more
TL;DR: In hospitalized adult patients with severe Covid-19, no benefit was observed with lopinavir–ritonavir treatment beyond standard care, and future trials in patients withsevere illness may help to confirm or exclude the possibility of a treatment benefit.
Journal ArticleDOI
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial.
Yeming Wang,Yeming Wang,Dingyu Zhang,Guanhua Du,Ronghui Du,Jianping Zhao,Yang Jin,Shouzhi Fu,Ling Gao,Zhenshun Cheng,Qiaofa Lu,Yi Hu,Guangwei Luo,Ke Wang,Yang Lu,Huadong Li,Shuzhen Wang,Shunan Ruan,Chengqing Yang,Chunlin Mei,Yi Wang,Dan Ding,Feng Wu,Xin Tang,Xianzhi Ye,Yingchun Ye,Bing Liu,Jie Yang,Wen Yin,Aili Wang,Guohui Fan,Fei Zhou,Zhibo Liu,Xiaoying Gu,Jiuyang Xu,Lianhan Shang,Lianhan Shang,Yi Zhang,Lianjun Cao,Guo Tingting,Yan Wan,Hong Qin,Yushen Jiang,Thomas Jaki,Thomas Jaki,Frederick G. Hayden,Peter Horby,Bin Cao,Chen Wang +48 more
TL;DR: In this study of adult patients admitted to hospital for severe COVID-19, remdesivir was not associated with statistically significant clinical benefits, however, the numerical reduction in time to clinical improvement in those treated earlier requires confirmation in larger studies.
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Remdesivir for the Treatment of Covid-19 - Final Report.
John H. Beigel,Kay M. Tomashek,Lori E. Dodd,Aneesh K. Mehta,Barry S. Zingman,Andre C. Kalil,Elizabeth L. Hohmann,Helen Y. Chu,Annie Luetkemeyer,Susan Kline,Diego Lopez de Castilla,Robert W. Finberg,Kerry Dierberg,Victor F. Tapson,Lanny Hsieh,Thomas F. Patterson,Roger Paredes,Daniel A. Sweeney,William R. Short,Giota Touloumi,David Chien Lye,Norio Ohmagari,Myoung-don Oh,Guillermo M. Ruiz-Palacios,Thomas Benfield,Gerd Fätkenheuer,Mark G. Kortepeter,Robert L. Atmar,C. Buddy Creech,JD Lundgren,Abdel G. Babiker,Sarah Pett,James D. Neaton,Timothy Burgess,Tyler Bonnett,Michelle Green,Mat Makowski,Anu Osinusi,Seema U Nayak,H. Clifford Lane +39 more
Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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