Autophagy: process and function
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TLDR
In this review, the process of autophagy is summarized, and the role of autophileagy is discussed in a process-based manner.Abstract:
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps--sequestration, transport to lysosomes, degradation, and utilization of degradation products--and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner.read more
Citations
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Genetic host factors in Helicobacter pylori-induced carcinogenesis: Emerging new paradigms.
TL;DR: A review of known carcinogenic effects of Helicobacter pylori can be found in this article, where the authors discuss recent findings that implicate host genetic pattern recognition pathways in the development of gastric cancer and their relation with H.pylori infection.
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MiR-200b regulates autophagy associated with chemoresistance in human lung adenocarcinoma
TL;DR: An inverse correlation between miR-200b and autophagy-associated gene 12 (ATG12) expressions was observed in docetaxel-resistant and sensitive LAD cells as well as in tissue samples, providing new evidence for the mechanisms governing the microRNA (miRNA)- ATG12 network and their possible contribution to Autophagy modulation and LAD chemoresistance.
Journal ArticleDOI
A nonapoptotic role for CASP2/caspase 2: Modulation of autophagy
Meenakshi Tiwari,Lokendra Kumar Sharma,Difernando Vanegas,Danielle A. Callaway,Yidong Bai,James D. Lechleiter,Brian Herman +6 more
TL;DR: A novel role is document for CASP2 as a negative regulator of autophagy, which may provide important insight into the role of CASP 2 in various processes including aging, neurodegeneration, and cancer.
Journal ArticleDOI
mTOR Signaling in Autophagy Regulation in the Kidney
TL;DR: The mechanistic/mammalian target of rapamycin, a serine/threonine protein kinase, is a key player in stimulating cellular anabolism in response to nutrients and growth factors, and plays a crucial role in suppressing autophagy activity.
Journal ArticleDOI
NF-kappaB P50/P65 hetero-dimer mediates differential regulation of CD166/ALCAM expression via interaction with micoRNA-9 after serum deprivation, providing evidence for a novel negative auto-regulatory loop
Jiayi Wang,Zhidong Gu,Peihua Ni,Yongxia Qiao,Changqiang Chen,Xiangfan Liu,Jiafei Lin,Ning Chen,Qishi Fan +8 more
TL;DR: A novel negative auto-regulatory loop in which NF-κB mediates differential regulation of CD166 after SD is elucidated and it is proposed that miR-9 promotes cell migration largely due to inhibition ofCD166.
References
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Journal ArticleDOI
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
Yukiko Kabeya,Noboru Mizushima,Noboru Mizushima,Takashi Ueno,Akitsugu Yamamoto,Takayoshi Kirisako,Takayoshi Kirisako,Takeshi Noda,Takeshi Noda,Eiki Kominami,Yoshinori Ohsumi,Yoshinori Ohsumi,Tamotsu Yoshimori,Tamotsu Yoshimori +13 more
TL;DR: It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
Journal ArticleDOI
Development by Self-Digestion: Molecular Mechanisms and Biological Functions of Autophagy
Beth Levine,Daniel J. Klionsky +1 more
TL;DR: This review summarizes the current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development and identifies a set of evolutionarily conserved genes that are essential forAutophagy.
Journal ArticleDOI
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara,Kenji Nakamura,Makoto Matsui,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Yohko Nakahara,Rika Suzuki-Migishima,Minesuke Yokoyama,Kenji Mishima,Ichiro Saito,Hideyuki Okano,Noboru Mizushima +12 more
TL;DR: The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.
Journal ArticleDOI
p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy
Serhiy Pankiv,Terje Høyvarde Clausen,Trond Lamark,Andreas Brech,Jack-Ansgar Bruun,Heidi Outzen,Aud Øvervatn,Geir Bjørkøy,Terje Johansen +8 more
TL;DR: It is demonstrated that the previously reported aggresome-like induced structures containing ubiquitinated proteins in cytosolic bodies are dependent on p62 for their formation and p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy.
Book
Isolation and characterization
TL;DR: Animal Models and Therapy, Directed Differentiation and Characterization of Genetically Modified Embryonic Stem Cells for Therapy, and Use of Differentiating Embryonics Stem cells in the Parkinsonian Mouse Model are reviewed.