Autophagy: process and function
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TLDR
In this review, the process of autophagy is summarized, and the role of autophileagy is discussed in a process-based manner.Abstract:
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps--sequestration, transport to lysosomes, degradation, and utilization of degradation products--and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner.read more
Citations
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Delicaflavone induces autophagic cell death in lung cancer via Akt/mTOR/p70S6K signaling pathway
Yuxia Sui,Hong Yao,Shaoguang Li,Long Jin,Peiying Shi,Zhijun Li,Gang Wang,Shilan Lin,Youjia Wu,Yuxiang Li,Liying Huang,Qicai Liu,Xinhua Lin +12 more
TL;DR: Delicaflavone is a potential anticancer agent that can induce autophagic cell death in human non-small cell lung cancer via the Akt/mTOR/p70S6K signaling pathway and may represent a potential therapeutic agent for lung cancer.
Journal ArticleDOI
ER membranes associated with mitochondria: Possible therapeutic targets in heart-associated diseases.
TL;DR: This review highlights MAMs' alterations mainly in cardiomyocytes, linked with cardiovascular diseases, such as cardiac ischemia-reperfusion, heart failure, and dilatedCardiovascular system cell biology is tightly regulated and mitochondria play a relevant role in maintaining heart function.
Journal ArticleDOI
Matrine induces apoptosis and autophagy of glioma cell line U251 by regulation of circRNA-104075/BCL-9.
TL;DR: It is suggested that matrine induced apoptosis and autophagy through down-regulating circ-104075 and Bcl-9 expression via inhibition of PI3K/AKT and Wnt-β-catenin pathways in glioma cells.
Journal ArticleDOI
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Jingjun Wu,Chun Yang,Chao Guo,Xiaorui Li,Nan Yang,Lijian Zhao,Hongdong Hang,Shumin Liu,Peng Chu,Zhengwu Sun,Bin Sun,Yuan Lin,Jinyong Peng,Guozhu Han,Shisheng Wang,Zeyao Tang +15 more
TL;DR: SZC015 played an important role in the regulation of autophagy and apoptosis in breast cancer cells and was able to activate intrinsic apoptosis, according to the present study.
Journal ArticleDOI
Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect
TL;DR: The role of autophagy as a double-edged sword in cancer has gained much attention as mentioned in this paper, with emphasis on the dual-role of auto-phagophore in cancer.
References
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Journal ArticleDOI
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
Yukiko Kabeya,Noboru Mizushima,Noboru Mizushima,Takashi Ueno,Akitsugu Yamamoto,Takayoshi Kirisako,Takayoshi Kirisako,Takeshi Noda,Takeshi Noda,Eiki Kominami,Yoshinori Ohsumi,Yoshinori Ohsumi,Tamotsu Yoshimori,Tamotsu Yoshimori +13 more
TL;DR: It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
Journal ArticleDOI
Development by Self-Digestion: Molecular Mechanisms and Biological Functions of Autophagy
Beth Levine,Daniel J. Klionsky +1 more
TL;DR: This review summarizes the current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development and identifies a set of evolutionarily conserved genes that are essential forAutophagy.
Journal ArticleDOI
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara,Kenji Nakamura,Makoto Matsui,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Yohko Nakahara,Rika Suzuki-Migishima,Minesuke Yokoyama,Kenji Mishima,Ichiro Saito,Hideyuki Okano,Noboru Mizushima +12 more
TL;DR: The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.
Journal ArticleDOI
p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy
Serhiy Pankiv,Terje Høyvarde Clausen,Trond Lamark,Andreas Brech,Jack-Ansgar Bruun,Heidi Outzen,Aud Øvervatn,Geir Bjørkøy,Terje Johansen +8 more
TL;DR: It is demonstrated that the previously reported aggresome-like induced structures containing ubiquitinated proteins in cytosolic bodies are dependent on p62 for their formation and p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy.
Book
Isolation and characterization
TL;DR: Animal Models and Therapy, Directed Differentiation and Characterization of Genetically Modified Embryonic Stem Cells for Therapy, and Use of Differentiating Embryonics Stem cells in the Parkinsonian Mouse Model are reviewed.