Autophagy: process and function
Reads0
Chats0
TLDR
In this review, the process of autophagy is summarized, and the role of autophileagy is discussed in a process-based manner.Abstract:
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps--sequestration, transport to lysosomes, degradation, and utilization of degradation products--and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner.read more
Citations
More filters
Journal ArticleDOI
Oxidative stress mediated cytotoxicity of biologically synthesized silver nanoparticles in human lung epithelial adenocarcinoma cell line
Jae Woong Han,Sangiliyandi Gurunathan,Jae-Kyo Jeong,Yun-Jung Choi,Deug-Nam Kwon,Jin-Ki Park,Jin-Hoi Kim +6 more
TL;DR: The results demonstrated that human lung epithelial A549 cells could provide a valuable model to assess the cytotoxicity of silver nanoparticles, and indicate that silver nanoparticle play a significant role in apoptosis.
Journal ArticleDOI
Biogenic silver nanoparticles based on trichoderma harzianum : synthesis, characterization, toxicity evaluation and biological activity
Mariana Guilger,Tatiane Pasquoto-Stigliani,Natalia Bilesky-José,Renato Grillo,Purushothaman Chirakkuzhyil Abhilash,Leonardo Fernandes Fraceto,Renata de Lima +6 more
TL;DR: Silver nanoparticles were biogenically synthesized using the fungus Trichoderma harzianum and characterized, showing potential against S. sclerotiorum, inhibiting sclerotinia germination and mycelial growth.
Journal ArticleDOI
Toll-like receptor signaling in the lysosomal pathways
TL;DR: Recent views on how Toll‐like receptors direct microbes to final destruction by regulating the different pathways that lead to the lysosome are discussed.
Journal ArticleDOI
Emerging beneficial roles of sirtuins in heart failure
TL;DR: Current knowledge of sirtuin functions in the heart is summarized and its translation into therapy for heart failure is discussed.
Journal ArticleDOI
Mitochondrial dynamics and viral infections: A close nexus
TL;DR: How mitochondrial dynamics is affected during viral infections and how this complex interplay benefits the viral infectious process and associated diseases is reviewed.
References
More filters
Journal ArticleDOI
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
Yukiko Kabeya,Noboru Mizushima,Noboru Mizushima,Takashi Ueno,Akitsugu Yamamoto,Takayoshi Kirisako,Takayoshi Kirisako,Takeshi Noda,Takeshi Noda,Eiki Kominami,Yoshinori Ohsumi,Yoshinori Ohsumi,Tamotsu Yoshimori,Tamotsu Yoshimori +13 more
TL;DR: It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
Journal ArticleDOI
Development by Self-Digestion: Molecular Mechanisms and Biological Functions of Autophagy
Beth Levine,Daniel J. Klionsky +1 more
TL;DR: This review summarizes the current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development and identifies a set of evolutionarily conserved genes that are essential forAutophagy.
Journal ArticleDOI
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara,Kenji Nakamura,Makoto Matsui,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Yohko Nakahara,Rika Suzuki-Migishima,Minesuke Yokoyama,Kenji Mishima,Ichiro Saito,Hideyuki Okano,Noboru Mizushima +12 more
TL;DR: The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.
Journal ArticleDOI
p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy
Serhiy Pankiv,Terje Høyvarde Clausen,Trond Lamark,Andreas Brech,Jack-Ansgar Bruun,Heidi Outzen,Aud Øvervatn,Geir Bjørkøy,Terje Johansen +8 more
TL;DR: It is demonstrated that the previously reported aggresome-like induced structures containing ubiquitinated proteins in cytosolic bodies are dependent on p62 for their formation and p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy.
Book
Isolation and characterization
TL;DR: Animal Models and Therapy, Directed Differentiation and Characterization of Genetically Modified Embryonic Stem Cells for Therapy, and Use of Differentiating Embryonics Stem cells in the Parkinsonian Mouse Model are reviewed.