Autophagy: process and function
Reads0
Chats0
TLDR
In this review, the process of autophagy is summarized, and the role of autophileagy is discussed in a process-based manner.Abstract:
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps--sequestration, transport to lysosomes, degradation, and utilization of degradation products--and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner.read more
Citations
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Autophagy: cellular and molecular mechanisms.
TL;DR: This review summarizes the most up‐to‐date findings on how autophagy is executed and regulated at the molecular level and how its disruption can lead to disease.
Journal ArticleDOI
TFEB links autophagy to lysosomal biogenesis.
Carmine Settembre,Chiara Di Malta,Vinicia Assunta Polito,Vinicia Assunta Polito,Moises Garcia Arencibia,Francesco Vetrini,Serkan Erdin,Serkan Erdin,Serpil Uckac Erdin,Serpil Uckac Erdin,Tuong Huynh,Tuong Huynh,Diego L. Medina,Pasqualina Colella,Marco Sardiello,Marco Sardiello,David C. Rubinsztein,Andrea Ballabio +17 more
TL;DR: A mitogen-activated protein kinase–dependent mechanism regulates autophagy by controlling the biogenesis and partnership of two distinct cellular organelles during starvation.
Journal ArticleDOI
Role of autophagy in cancer
TL;DR: Evidence suggests that autophagy provides a protective function to limit tumour necrosis and inflammation, and to mitigate genome damage in tumour cells in response to metabolic stress.
Journal ArticleDOI
Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy
Nao Hosokawa,Taichi Hara,Takeshi Kaizuka,Chieko Kishi,Akito Takamura,Yutaka Miura,Shun-ichiro Iemura,Tohru Natsume,Kenji Takehana,Naoyuki Yamada,Jun-Lin Guan,Noriko Oshiro,Noriko Oshiro,Noboru Mizushima +13 more
TL;DR: A novel mammalian autophagy factor, Atg13, is reported, which forms a stable approximately 3-MDa protein complex with ULK1 and FIP200, and suggests that mTORC1 suppressesAutophagy through direct regulation of the approximately 3,MDa ULK 1-Atg13-FIP200 complex.
References
More filters
Journal ArticleDOI
Disruption of autophagy results in constitutive oxidative stress in Arabidopsis.
TL;DR: Analysis of protein oxidation indicated that oxidized proteins are degraded in the vacuole after uptake by autophagy, and this degradation is impaired in RNAi-AtATG18a lines, suggesting that in the absence of a functional autophagic pathway, plants are under increased oxidative stress, even under normal growth conditions.
Journal ArticleDOI
Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiae.
Yukiko Kabeya,Tomoko Kawamata,Kuninori Suzuki,Kuninori Suzuki,Yoshinori Ohsumi,Yoshinori Ohsumi +5 more
TL;DR: This work identifies Cis1/Atg31 as a protein that exhibits similar phenotypes to Atg17, a novel protein that is required for proper autophagosome formation in yeast Saccharomyces cerevisiae.
Journal ArticleDOI
Characterization of a novel autophagy-specific gene, ATG29.
Tomoko Kawamata,Yoshiaki Kamada,Yoshiaki Kamada,Kuninori Suzuki,Kuninori Suzuki,Norihiro Kuboshima,Hiroshi Akimatsu,Shinichi Ota,Mariko Ohsumi,Yoshinori Ohsumi,Yoshinori Ohsumi +10 more
TL;DR: It is proposed that Atg29 functions in autophagosome formation at the pre-autophagosomal structure (PAS) in collaboration with other Atg proteins.
Journal ArticleDOI
Autophagic degradation of peroxisomes in isolated rat hepatocytes.
TL;DR: It is concluded that preferential autophagy of peroxisomes is prevented when these organelles are supplied with their fatty acid substrates and the proposal that autophagic sequestration can be highly selective is provided.
Journal ArticleDOI
A microbial strategy to multiply in macrophages: the pregnant pause.
TL;DR: The bimorphic life cycles of three pathogens have dramatic consequences for phagosome traffic, and scrutinizing the life styles of these shrewd microbes can deduce how macrophages routinely mount an effective immune response.