Autophagy: process and function
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TLDR
In this review, the process of autophagy is summarized, and the role of autophileagy is discussed in a process-based manner.Abstract:
Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are sometimes complex. Autophagy consists of several sequential steps--sequestration, transport to lysosomes, degradation, and utilization of degradation products--and each step may exert different function. In this review, the process of autophagy is summarized, and the role of autophagy is discussed in a process-based manner.read more
Citations
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Journal ArticleDOI
Dual role of autophagy in hallmarks of cancer.
Shikha Satendra Singh,Somya Vats,Amelia Yi-Qian Chia,Tuan Zea Tan,Shuo Deng,Mei Shan Ong,Frank Arfuso,Celestial T. Yap,Boon Cher Goh,Gautam Sethi,Gautam Sethi,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,Han-Ming Shen,Ravi Manjithaya,Alan Prem Kumar +15 more
TL;DR: This review will provide a novel insight into the mutational landscapes of autophagy-related genes in several human cancers, using genetic information collected from an array of cancers.
Journal ArticleDOI
Mitochondrial dynamics, mitophagy and cardiovascular disease
César Vásquez-Trincado,Ivonne Garcia-Carvajal,Christian Pennanen,Valentina Parra,Valentina Parra,Joseph A. Hill,Beverly A. Rothermel,Sergio Lavandero,Sergio Lavandero +8 more
TL;DR: In this paper, the authors discuss the latest findings regarding the impact of mitochondrial dynamics and mitophagy on the development and progression of cardiovascular pathologies, including diabetic cardiomyopathy, atherosclerosis, damage from ischaemia-reperfusion, cardiac hypertrophy and decompensated heart failure.
Journal ArticleDOI
Structural basis of target recognition by Atg8/LC3 during selective autophagy.
Nobuo N. Noda,Hiroyuki Kumeta,Hitoshi Nakatogawa,Hitoshi Nakatogawa,Kenji Satoo,Wakana Adachi,Junko Ishii,Junko Ishii,Yuko Fujioka,Yoshinori Ohsumi,Fuyuhiko Inagaki +10 more
TL;DR: The results show the fundamental mechanism that allows Atg8 homologues, in association with WXXL‐containing proteins, to capture specific cargo molecules, thereby endowing isolation membranes and/or their assembly machineries with target selectivity.
Journal ArticleDOI
Aggrephagy: selective disposal of protein aggregates by macroautophagy.
Trond Lamark,Terje Johansen +1 more
TL;DR: The processes of aggregate formation, recognition, transport, and sequestration into autophagosomes by autophagy receptors and the role of aggrephagy in different protein aggregation diseases are reviewed.
Journal ArticleDOI
Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy
Dian J. Cao,Zhao V. Wang,Pavan K. Battiprolu,Nan Jiang,Cyndi R. Morales,Yongli Kong,Beverly A. Rothermel,Thomas G. Gillette,Joseph A. Hill +8 more
TL;DR: RNAi experiments implicate autophagy as an obligatory element in pathological cardiac remodeling and point to HDAC1/2 as required effectors, and reveal autophileagy as a previously unknown target of HDAC inhibitor therapy.
References
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LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
Yukiko Kabeya,Noboru Mizushima,Noboru Mizushima,Takashi Ueno,Akitsugu Yamamoto,Takayoshi Kirisako,Takayoshi Kirisako,Takeshi Noda,Takeshi Noda,Eiki Kominami,Yoshinori Ohsumi,Yoshinori Ohsumi,Tamotsu Yoshimori,Tamotsu Yoshimori +13 more
TL;DR: It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
Journal ArticleDOI
Development by Self-Digestion: Molecular Mechanisms and Biological Functions of Autophagy
Beth Levine,Daniel J. Klionsky +1 more
TL;DR: This review summarizes the current knowledge about the molecular machinery of autophagy and the role of the autophagic machinery in eukaryotic development and identifies a set of evolutionarily conserved genes that are essential forAutophagy.
Journal ArticleDOI
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara,Kenji Nakamura,Makoto Matsui,Makoto Matsui,Makoto Matsui,Akitsugu Yamamoto,Yohko Nakahara,Rika Suzuki-Migishima,Minesuke Yokoyama,Kenji Mishima,Ichiro Saito,Hideyuki Okano,Noboru Mizushima +12 more
TL;DR: The results suggest that the continuous clearance of diffuse cytosolic proteins through basal autophagy is important for preventing the accumulation of abnormal proteins, which can disrupt neural function and ultimately lead to neurodegeneration.
Journal ArticleDOI
p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy
Serhiy Pankiv,Terje Høyvarde Clausen,Trond Lamark,Andreas Brech,Jack-Ansgar Bruun,Heidi Outzen,Aud Øvervatn,Geir Bjørkøy,Terje Johansen +8 more
TL;DR: It is demonstrated that the previously reported aggresome-like induced structures containing ubiquitinated proteins in cytosolic bodies are dependent on p62 for their formation and p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy.
Book
Isolation and characterization
TL;DR: Animal Models and Therapy, Directed Differentiation and Characterization of Genetically Modified Embryonic Stem Cells for Therapy, and Use of Differentiating Embryonics Stem cells in the Parkinsonian Mouse Model are reviewed.