Beyond oxidative stress: an immunologist’s guide to reactive oxygen species
Reads0
Chats0
TLDR
ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate — challenges the authors must overcome to translate ROS biology into medical advances.Abstract:
Reactive oxygen species (ROS) react preferentially with certain atoms to modulate functions ranging from cell homeostasis to cell death. Molecular actions include both inhibition and activation of proteins, mutagenesis of DNA and activation of gene transcription. Cellular actions include promotion or suppression of inflammation, immunity and carcinogenesis. ROS help the host to compete against microorganisms and are also involved in intermicrobial competition. ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate — challenges we must overcome to translate ROS biology into medical advances.read more
Citations
More filters
Journal ArticleDOI
Association between paraoxonase-1 gene Q192R and L55M polymorphisms and risk of gastric cancer: A case-control study from Iran.
TL;DR: The results demonstrated the protective effect of Q allele against gastric cancer.
Journal ArticleDOI
Febuxostat, a Xanthine Oxidase Inhibitor, Decreased Macrophage Matrix Metalloproteinase Expression in Hypoxia.
Shuoyu Wei,Takayuki Isagawa,Takayuki Isagawa,Masamichi Eguchi,Daisuke Sato,Hiroto Tsukano,Keishi Miyata,Yuichi Oike,Norihiko Takeda,Satoshi Ikeda,Hiroaki Kawano,Koji Maemura +11 more
TL;DR: The results indicate that febuxostat stabilized atherosclerotic plaque via suppressing the activities of macrophage MMP-9 and -13 and thatFebuxostats administration is a potential therapeutic option in the management of atherosclerosis patients.
Prenatal inflammation exposure-programmed cardiovascular diseases and potential prevention
TL;DR: The need for future mechanistic studies and biomarker screenings in this important field creates a great opportunity to combat the global increase in CVDs by managing the adverse effects of inflammation for prepregnant and pregnant individuals who are at risk for PIE-programmedCVDs.
Journal ArticleDOI
Chemogenetic Approaches to Probe Redox Pathways: Implications for Cardiovascular Pharmacology and Toxicology
TL;DR: In this article , the combination of chemogenetic approaches with biosensor methodologies has opened up new lines of investigation, allowing the analysis of intracellular redox pathways that modulate physiological and pathological cell responses.
Journal ArticleDOI
Increasing NADPH impairs fungal H2O2 resistance by perturbing transcriptional regulation of peroxiredoxin
TL;DR: In this paper , a conditional expression of glucose-6-phosphate dehydrogenase (G6PD)-strain was constructed to manipulate intracellular NADPH levels.
References
More filters
Journal ArticleDOI
Superoxide Dismutase AN ENZYMIC FUNCTION FOR ERYTHROCUPREIN (HEMOCUPREIN)
Joe M. McCord,Irwin Fridovich +1 more
TL;DR: The demonstration that O2·- can reduce ferricytochrome c and tetranitromethane, and that superoxide dismutase, by competing for the superoxide radicals, can markedly inhibit these reactions, is demonstrated.
Journal ArticleDOI
Myeloid-derived suppressor cells as regulators of the immune system.
TL;DR: The origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit are discussed.
Journal ArticleDOI
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
TL;DR: It is argued that modulating the unique redox regulatory mechanisms of cancer cells might be an effective strategy to eliminate these cells.
Journal ArticleDOI
A role for mitochondria in NLRP3 inflammasome activation
TL;DR: It is shown that mitophagy/autophagy blockade leads to the accumulation of damaged, ROS-generating mitochondria, and this in turn activates the NLRP3 inflammasome, and may explain the frequent association of mitochondrial damage with inflammatory diseases.
Journal ArticleDOI
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent.
TL;DR: O(2) (-) is made by leukocytes under circumstances which suggest that it may be involved in bacterial killing, and is identified as the agent responsible for the leukocyte-mediated reduction of cytochrome c.