Beyond oxidative stress: an immunologist’s guide to reactive oxygen species
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TLDR
ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate — challenges the authors must overcome to translate ROS biology into medical advances.Abstract:
Reactive oxygen species (ROS) react preferentially with certain atoms to modulate functions ranging from cell homeostasis to cell death. Molecular actions include both inhibition and activation of proteins, mutagenesis of DNA and activation of gene transcription. Cellular actions include promotion or suppression of inflammation, immunity and carcinogenesis. ROS help the host to compete against microorganisms and are also involved in intermicrobial competition. ROS chemistry and their pleiotropy make them difficult to localize, to quantify and to manipulate — challenges we must overcome to translate ROS biology into medical advances.read more
Citations
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Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing
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Stem cells and the impact of ROS signaling
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The role of oxidative stress during inflammatory processes
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The Redox Code
Dean P. Jones,Helmut Sies +1 more
TL;DR: The redox code is a set of principles that defines the positioning of the nicotinamide adenine dinucleotide and thiol/disulfide and other redox systems as well as the thiol redox proteome in space and time in biological systems.
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Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance.
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References
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